The Functional Characterization of Epigenetically Related lncRNAs Involved in Dysregulated CeRNA–CeRNA Networks Across Eight Cancer Types [PDF]
Frontiers in Cell and Developmental Biology, 2021 Numerous studies have demonstrated that lncRNAs could compete with other RNAs to bind miRNAs, as competing endogenous RNAs (ceRNAs), to regulate each other. On the other hand, ceRNAs were found to be recurrently dysregulated in cancer status. However, limited studies considered the upstream epigenetic regulatory factors that disrupted the normal ...
Dahua Xu +11 more
openaire +3 more sources
Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression
Molecular Medicine Reports, 2019 The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease.
Lang, Yan, Zhang, Jingchao, Yuan, Zheng
openaire +3 more sources
Whole-Transcriptome Sequencing Integrative Analyses Reveal Expression Profiles and ceRNA Regulatory Network of Huoyan Goose Egg Production. [PDF]
Animals (Basel)Liu Y +6 more
europepmc +3 more sources
PVT1: a rising star among oncogenic long non-coding RNAs [PDF]
, 2015 It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function.
Colombo, Teresa +3 more
core +4 more sources
The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity [PDF]
, 2017 Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system. Dysregulated lncRNA expression has been documented in several human cancers, and their tissue-specificity
Alfano, Vincenzo +14 more
core +1 more source
ceRNA analysis of SARS-CoV-2 [PDF]
Archives of Virology, 2020 Viral RNAs can perturb the miRNA regulatory network, competing with host RNAs as part of their infective process. An in silico competing endogenous RNA (ceRNA) analysis has been carried on SARS-CoV-2. The results suggest that, in humans, the decrease of microRNA activity caused by viral RNAs can lead to a perturbation of vesicle trafficking and the ...
openaire +2 more sources
Construction of ceRNA regulatory networks for osteoporosis
Molecular Medicine Reports, 2023 Osteoporosis increases the risk of fracture. Improving the diagnosis and treatment of osteoporosis has clinical applications. The differentially expressed genes (DEcircRs, DEmRs, DEmiRs) of osteoporotic patients and controls were analyzed using the GEO database, and enrichment analysis of DEmRs was performed. circRNAs and mRNAs, which were predicted to
Chen, Hongtao +5 more
openaire +2 more sources
Constraining sleptons at the LHC in a supersymmetric low-scale seesaw scenario [PDF]
, 2017 We consider a scenario inspired by natural supersymmetry, where neutrino data is explained within a low-scale seesaw scenario. We extend the Minimal Supersymmetric Standard Model by adding light right-handed neutrinos and their superpartners, the R ...
Cerna-Velazco, Nhell +3 more
core +2 more sources
Interactions between Distant ceRNAs in Regulatory Networks [PDF]
Biophysical Journal, 2014 Competing endogenous RNAs (ceRNAs) were recently introduced as RNA transcripts that affect each other's expression level through competition for their microRNA (miRNA) coregulators. This stems from the bidirectional effects between miRNAs and their target RNAs, where a change in the expression level of one target affects the level of the miRNA ...
Mor Nitzan +4 more
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Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion [PDF]
, 2017 Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions.
Chen, Xiao-wan +9 more
core +2 more sources