Results 11 to 20 of about 42,399 (240)
An Overview of the Computational Models Dealing with the Regulatory ceRNA Mechanism and ceRNA Deregulation in Cancer [PDF]
, 2021 Pools of RNA molecules can act as competing endogenous RNAs (ceRNAs) and indirectly alter their expression levels by competitively binding shared microRNAs. This ceRNA cross talk yields an additional posttranscriptional regulatory layer, which plays key roles in both physiological and pathological processes.
Conte F. +4 more
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Perdarahan Saluran Cerna pada Anak dengan Penyakit Ginjal Tahap Akhir [PDF]
Sari Pediatri, 2023 Penyakit ginjal tahap akhir (PGTA) adalah penyakit ginjal kronik (PGK) stadium 5 yang ditandai dengan laju filtrasi glomerulus (LFG) < 15 mL/menit/1,73m2 selama tiga bulan atau lebih, atau suatu kondisi dengan pasien memerlukan terapi pengganti ginjal ...
Beatrix Siregar +2 more
doaj +3 more sources
High-throughput validation of ceRNA regulatory networks [PDF]
BMC Genomics, 2017 Background: MicroRNAs (miRNAs) play multiple roles in tumor biology [1]. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive stoichiometric sequestration [2]. Specifically, computational models predicted [3, 4] and experimental assays confirmed [5, 6] that miRNA activity is dependent on miRNA target
Hua-Sheng Chiu +7 more
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Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer [PDF]
PLOS ONE, 2017 Recent findings have identified competing endogenous RNAs (ceRNAs) as the drivers in many disease conditions, including cancers. The ceRNAs indirectly regulate each other by reducing the amount of microRNAs (miRNAs) available to target messenger RNAs (mRNAs). The ceRNA interactions mediated by miRNAs are modulated by a titration mechanism, i.e.
Conte F +5 more
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Out-of-Equilibrium ceRNA Crosstalk [PDF]
Amongst non-coding RNAs, microRNAs are pivotal post-transcriptionalregulators of gene expression in higher eukaryotes. Through a titration-based mech-anism of interaction with their target RNAs, microRNAs can mediate a weak butpervasive form of RNA cross-regulation, as different endogenous RNAs can be ef-fectively coupled by competing for microRNA ...
Ferro, Elsi +5 more
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miRTissue ce: extending miRTissue web service with the analysis of ceRNA-ceRNA interactions [PDF]
BMC Bioinformatics, 2020 Abstract Background Non-coding RNAs include different classes of molecules with regulatory functions. The most studied are microRNAs (miRNAs) that act directly inhibiting mRNA expression or protein translation through the interaction with a miRNAs-response element. Other RNA molecules participate in the complex network of gene regulation.
Antonino Fiannaca +4 more
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Deciphering the rules of ceRNA networks [PDF]
Proceedings of the National Academy of Sciences, 2013 Recent theoretical and experimental studies have shed light on the complex network of interactions among the multiple classes of RNA within the cell. Although much of the focus over the past decade has been on the mechanisms by which microRNAs (miRNA) regulate the stability and translation of messenger RNAs (mRNAs), more recently it has come to light ...
Marcella, Cesana, George Q, Daley
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LncRNA MIR155HG functions as a ceRNA for inhibition of lung adenocarcinoma growth and prediction of prognosis [PDF]
, 2021 Introduction Long non-coding RNAs (lncRNAs) functioning as competing endogenous RNAs (ceRNAs) play critical roles in tumour progression. However, prognosis-related ceRNA networks in lung adenocarcinoma (LUAD) have not been well characterised.
Jing Wang, Jie Li
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Roles of ncRNAs as ceRNAs in Gastric Cancer [PDF]
Genes, 2021 Although ignored in the past, with the recent deepening of research, significant progress has been made in the field of non-coding RNAs (ncRNAs). Accumulating evidence has revealed that microRNA (miRNA) response elements regulate RNA. Long ncRNAs, circular RNAs, pseudogenes, miRNAs, and messenger RNAs (mRNAs) form a competitive endogenous RNA (ceRNA ...
Junhong Ye, Jifu Li, Ping Zhao
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, 2022 Three ceRNA networks comprised AQP9, IL1B, and IL1RN, as well as possible RNA regulatory mechanisms.
Guangyao Shao (12174674)
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