Results 11 to 20 of about 26,094 (208)

Translating ceRNA susceptibilities into correlation functions [PDF]

Biophysical Journal, 2017
Competition to bind microRNAs induces an effective positive crosstalk between their targets, therefore known as ‘competing endogenous RNAs’ or ceRNAs. While such an effect is known to play a significant role in specific situations, estimating its strength from data and, experimentally, in physiological conditions appears to be far ...
Martirosyan, A., Marsili, M., De Martino, A.   +2 more
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Construction of ceRNA regulatory networks for osteoporosis

Molecular Medicine Reports, 2023
Osteoporosis increases the risk of fracture. Improving the diagnosis and treatment of osteoporosis has clinical applications. The differentially expressed genes (DEcircRs, DEmRs, DEmiRs) of osteoporotic patients and controls were analyzed using the GEO database, and enrichment analysis of DEmRs was performed. circRNAs and mRNAs, which were predicted to
Chen, Hongtao, Wang, Hailong, Liu, Xu, Li, Long, Abudusimu, Yiliyaer, Tuoheti, Yilihamu   +5 more
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Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression

Molecular Medicine Reports, 2019
The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease.
Lang, Yan, Zhang, Jingchao, Yuan, Zheng
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An In Silico Approach to Define Potential Biomarkers of miRNA-Associated ceRNAs for Breast Cancer

Cumhuriyet Science Journal, 2023
Breast cancer (BC) is the most common type of cancer with the highest incidence in women. Particularly in breast cancer, competing endogenous RNAs (ceRNAs) play crucial roles in a variety of metabolic pathways including proliferation, migration, and ...
Serap Ozer Yaman, Sema Mısır
doaj   +1 more source

The mRNA related ceRNA–ceRNA landscape and significance across 20 major cancer types [PDF]

Nucleic Acids Research, 2015
Cross-talk between competitive endogenous RNAs (ceRNAs) through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of cancers. However, a global view of their system-level properties across various types of cancers is still unknown.
Xu, Juan, Li, Yongsheng, Lu, Jianping, Pan, Tao, Ding, Na, Wang, Zishan, Shao, Tingting, Zhang, Jinwen, Wang, Lihua, Li, Xia   +9 more
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lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells

Open Medicine, 2022
Gastric cancer (GC) is one of the most common malignancies in digestive system. Accumulating evidence reveals the critical role of long noncoding RNAs (lncRNAs) in GC development.
Liu Zhiping, Hu Kaibing, Wang Xiang, Zhang Youqian, Wang Weiping, Wu Yindi   +5 more
doaj   +1 more source

LncRNA PART1 Regulates Ovarian Carcinoma Development via the miR-150-5p/MYB Axis

Frontiers in Bioscience-Landmark, 2023
Background: Over the past few years, there have been many reports on the abnormal expression and functional relevance of long non-coding RNAs (lncRNAs) in tumors. The role played by lncRNAs in epithelial ovarian carcinoma (EOC) remains poorly understood,
Jing Wang, Yun Han, Tingting Zhang, Jing Li, Boqun Xu   +4 more
doaj   +1 more source

Gene signature to predict prognostic survival of hepatocellular carcinoma

Open Medicine, 2022
Hepatocellular carcinoma (HCC) has a high incidence and poor prognosis and is the second most fatal cancer, and certain HCC patients also show high heterogeneity. This study developed a prognostic model for predicting clinical outcomes of HCC.
Li Li, Cao Yundi, Fan YingRui, Li Rong
doaj   +1 more source

circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8

Open Medicine, 2022
High circ_0020123 expression is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC) as previously reported. Whether circ_0020123 also plays an oncogenic role in lung adenocarcinoma (LUAD) is still unknown.
Wei Wei, Wang Changyong, Wang Lele, Zhang Jianfeng   +3 more
doaj   +1 more source

PTENP1 is a ceRNA for PTEN: it’s CRISPR clear [PDF]

Journal of Hematology & Oncology, 2020
AbstractHere we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer. Our data expand the repertoire of approaches that can be used to dissect competing endogenous RNA (ceRNA)-based interactions, while ...
Vitiello M., Evangelista M., Zhang Y., Salmena L., Pandolfi P. P., Poliseno L.   +5 more
openaire   +6 more sources