Results 21 to 30 of about 28,293 (248)
circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8
Open Medicine, 2022 High circ_0020123 expression is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC) as previously reported. Whether circ_0020123 also plays an oncogenic role in lung adenocarcinoma (LUAD) is still unknown.
Wei Wei +3 more
doaj +1 more source
Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression
Molecular Medicine Reports, 2019 The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease.
Lang, Yan, Zhang, Jingchao, Yuan, Zheng
openaire +3 more sources
LncRNA THUMPD3-AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR-485-5p and ARHGAP8. [PDF]
Adv Sci (Weinh)Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Gong X +9 more
europepmc +2 more sources
ceRNA analysis of SARS-CoV-2 [PDF]
Archives of Virology, 2020 Viral RNAs can perturb the miRNA regulatory network, competing with host RNAs as part of their infective process. An in silico competing endogenous RNA (ceRNA) analysis has been carried on SARS-CoV-2. The results suggest that, in humans, the decrease of microRNA activity caused by viral RNAs can lead to a perturbation of vesicle trafficking and the ...
openaire +2 more sources
Construction of ceRNA regulatory networks for osteoporosis
Molecular Medicine Reports, 2023 Osteoporosis increases the risk of fracture. Improving the diagnosis and treatment of osteoporosis has clinical applications. The differentially expressed genes (DEcircRs, DEmRs, DEmiRs) of osteoporotic patients and controls were analyzed using the GEO database, and enrichment analysis of DEmRs was performed. circRNAs and mRNAs, which were predicted to
Chen, Hongtao +5 more
openaire +2 more sources
Interactions between Distant ceRNAs in Regulatory Networks [PDF]
Biophysical Journal, 2014 Competing endogenous RNAs (ceRNAs) were recently introduced as RNA transcripts that affect each other's expression level through competition for their microRNA (miRNA) coregulators. This stems from the bidirectional effects between miRNAs and their target RNAs, where a change in the expression level of one target affects the level of the miRNA ...
Mor Nitzan +4 more
openaire +3 more sources
lncRNA-mediated ceRNA network in bladder cancer
Non-coding RNA Research, 2023 Bladder cancer is a common disease associated with high rates of morbidity and mortality. Although immunotherapy approaches such as adoptive T-cell therapy and immune checkpoint blockade have been investigated for the treatment of bladder cancer, their off-target effects and ability to affect only single targets have led to clinical outcomes that are ...
Kun Li, Tongyue Yao, Ziqiang Wang
openaire +3 more sources
Identification of circular RNA expression profiles in renal fibrosis induced by obstructive injury
Renal Failure, 2021 Introduction Advancing renal fibrosis is the common histopathological feature of chronic obstructive nephropathy, representing the final pathway of nearly all chronic and progressive nephropathies.
Jiangju Huang +7 more
doaj +1 more source
Transcription Profiling of a Revealed the Potential Molecular Mechanism of Governor Vessel Electroacupuncture for Spinal Cord Injury in Rats [PDF]
Neurospine, 2022 Objective This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal survival, axonal regeneration, and functional ...
Xingru Xiao +7 more
doaj +1 more source
LncRNA PART1 Regulates Ovarian Carcinoma Development via the miR-150-5p/MYB Axis
Frontiers in Bioscience-Landmark, 2023 Background: Over the past few years, there have been many reports on the abnormal expression and functional relevance of long non-coding RNAs (lncRNAs) in tumors. The role played by lncRNAs in epithelial ovarian carcinoma (EOC) remains poorly understood,
Jing Wang +4 more
doaj +1 more source