Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis
MicroRNAs (miRNAs) are a class of small non-coding RNAs ranging from 17 to 25 nt in length. miR-637 is down-regulated in most cancers and up-regulated only in clear cell renal cell carcinoma (ccRCC).
Jinze Shen+7 more
semanticscholar +1 more source
Extensive ceRNA–ceRNA interaction networks mediated by miRNAs regulate development in multiple rhesus tissues [PDF]
Crosstalk between RNAs mediated by shared microRNAs (miRNAs) represents a novel layer of gene regulation, which plays important roles in development. In this study, we analyzed time series expression data for coding genes and long non-coding RNAs (lncRNAs) to identify thousands of interactions among competitive endogenous RNAs (ceRNAs) in four rhesus ...
Zujing Han+15 more
openaire +2 more sources
circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8
High circ_0020123 expression is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC) as previously reported. Whether circ_0020123 also plays an oncogenic role in lung adenocarcinoma (LUAD) is still unknown.
Wei Wei+3 more
doaj +1 more source
Background. Myocardial ischemia/reperfusion (MI/R) injury is a common pathology in ischemia heart disease. Long noncoding RNAs (lncRNAs) are significant regulators related to many ischemia/reperfusion conditions.
Ying Han+6 more
semanticscholar +1 more source
Therapeutic prospects of ceRNAs in COVID-19
Since the end of 2019, COVID-19 caused by SARS-CoV-2 has spread worldwide, and the understanding of the new coronavirus is in a preliminary stage. Currently, immunotherapy, cell therapy, antiviral therapy, and Chinese herbal medicine have been applied in the clinical treatment of the new coronavirus; however, more efficient and safe drugs to control ...
Lin Liu+35 more
openaire +3 more sources
Transcription Profiling of a Revealed the Potential Molecular Mechanism of Governor Vessel Electroacupuncture for Spinal Cord Injury in Rats [PDF]
Objective This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal survival, axonal regeneration, and functional ...
Xingru Xiao+7 more
doaj +1 more source
Autophagy-Related Genes Predict the Progression of Periodontitis Through the ceRNA Network
Purpose The goal of this study was to identify the crucial autophagy-related genes (ARGs) in periodontitis and construct mRNA-miRNA-lncRNA networks to further understand the pathogenesis of periodontitis. Methods We used the Gene Expression Omnibus (GEO)
Mengyao Bian+5 more
semanticscholar +1 more source
The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA [PDF]
Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells.
Bozzoni, Irene+8 more
core +2 more sources
Construction of ceRNA Networks Associated With CD8 T Cells in Breast Cancer
Background The infiltration of CD8 T cells is usually linked to a favorable prognosis and may predict the therapeutic response of breast cancer patients to immunotherapy. The purpose of this research is to investigate the competing endogenous RNA (ceRNA)
Zhilin Chen+8 more
semanticscholar +1 more source
Postoperative cognitive dysfunction (POCD) is a clinical entity associated with declined cognitive function following surgery. It occurs more frequently in elderly patients.
Mengxiao Zhang+6 more
semanticscholar +1 more source