Results 111 to 120 of about 17,535 (240)

New Technologies Empower Hemophilic Arthropathy Treatment: Focusing on Regenerative Medicine, Molecular Targeting, and Gene Therapy

open access: yesMedicine Bulletin, Volume 2, Issue 1, Page 34-60, January 2026.
ABSTRACT Hemophilic arthropathy (HA), a major complication of hemophilia, is a chronic osteoarthropathy driven by repeated joint bleeding. Although traditional therapies such as coagulation factor replacement, physical rehabilitation, and surgery can manage symptoms, they cannot fundamentally repair established joint damage or break the pathological ...
Lin Sun   +8 more
wiley   +1 more source

Introduction of LPIN1 as a potential diagnostic and prognostic biomarker for gastric cancer via integrative bioinformatics analysis of a competing endogenous RNA network and experimental validation [PDF]

open access: yesIranian Journal of Basic Medical Sciences
Objective(s): Identification of effective biomarkers is crucial for the heterogeneous disease of gastric cancer (GC). Recent studies have focused on the role of pseudogenes regulating gene expression through competing endogenous RNA (ceRNA) networks ...
Milad Daneshmand-Parsa, Parvaneh Nikpour
doaj   +1 more source

CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis

open access: yesAnalytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Coiled‐coil domain‐containing 97 (CCDC97) can bind to the splicing factor SF3B complex to participate significantly in pre‐mRNA splicing. However, there may be a risk of cancer development in the case of disrupted mechanism, necessitating further in‐depth investigation of the underlying mechanism.
Changye Yang   +5 more
wiley   +1 more source

IPO9 Promotes Ovarian Cancer Progression by Suppressing HMOX1‐Dependent Ferroptosis

open access: yesHuman Mutation, Volume 2026, Issue 1, 2026.
Ovarian cancer (OC) poses a significant threat to women’s health, with current treatment strategies remaining suboptimal, necessitating the exploration of novel therapeutic targets and immune microenvironment dynamics. This study integrates multiomics data from TCGA, GEO, and IEU‐Open‐GWAS, employing scRNA‐seq, scPagwas, BayesPrism, and WGCNA to ...
Yimei Meng, Peiling Li, Sujit Nair
wiley   +1 more source

Dysregulated circRNAs and ceRNA network in esophageal squamous cell carcinoma

open access: yesFrontiers in Bioscience, 2019
Accumulating evidence suggests that circular RNA (circRNA), once thought to be a transcriptional error, plays an important regulatory role in the tumor biological process. Some circRNAs regulate the protein-coding gene expression by competitive binding with microRNAs (miRNAs).
Chao, Jiang   +4 more
openaire   +2 more sources

Identification of Prognostic Factors Related to Super Enhancer-Regulated ceRNA Network in Metastatic Lung Adenocarcinoma

open access: yesInternational Journal of General Medicine, 2021
Mingjiang Li,1 Bo Yang,1 Xiaoping Li,1 Haixia Ren,2 Liang Zhang,1 Lei Li,1 Wei Li,1 Xuhui Wang,1 Honggang Zhou,3 Weidong Zhang1 1Department of Thoracic Surgery, Tianjin First Central Hospital, Tianjin, People’s Republic of China; 2Department of Pharmacy,
Li M   +9 more
doaj  

Multi‐Omics Evidence Based on Spatial Transcriptomics Data Reveals the Therapeutic Value of Copper Death Genes in Glioblastoma

open access: yesInternational Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Cuprotosis is an emerging form of copper‐dependent programmed cell death, while low‐grade gliomas (LGGs) represent a common subtype of primary brain tumors. Methods Datasets from The Cancer Genome Atlas and TargetScan were utilized to identify cuprotosis‐related microRNAs (CRMs).
Zhaoliang Xue   +4 more
wiley   +1 more source

ceRNA networks in ischemic stroke: a bibliometric analysis

open access: yesEgyptian Journal of Medical Human Genetics
Abstract Background and method Ischemic stroke, a leading cause of death and disability worldwide, has been increasingly linked to ceRNA networks, which regulate neuronal damage and recovery. Despite growing interest, a comprehensive bibliometric analysis of ceRNA’s role in stroke remains limited.
Loo Keat Wei   +2 more
openaire   +2 more sources

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