Results 101 to 110 of about 4,440,633 (238)

The tumor suppressor role and ceRNA network of miR-1294 in cancer

Oncology Research, 2023
miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells.
MAO, YUNAN, SHEN, JINZE, FANG, LI, ZHU, FENG, DUAN, SHIWEI   +4 more
openaire   +2 more sources

Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information

BMC Genomics, 2019
Background A long noncoding RNA (lncRNA) can act as a competing endogenous RNA (ceRNA) to compete with an mRNA for binding to the same miRNA. Such an interplay between the lncRNA, miRNA, and mRNA is called a ceRNA crosstalk. As an miRNA may have multiple
Chaowang Lan, Hui Peng, Gyorgy Hutvagner, Jinyan Li   +3 more
doaj   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang, Hong‐Cheng Wei, Lin Jiang, Yi‐Sen Shao   +3 more
wiley   +1 more source

Identification of hub genes and potential ceRNA networks of diabetic cardiomyopathy

Scientific Reports, 2023
Abstract Diabetic cardiomyopathy (DCM), a common complication of diabetes, is defined as ventricular dysfunction in the absence of underlying heart disease. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in the development of DCM.
Jun Hou, Wan Yi Liang, Shiqiang Xiong, Pan Long, Tian Yue, Xudong Wen, Tianchen Wang, Haoyu Deng   +7 more
openaire   +3 more sources

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

BMC Ophthalmology, 2020
Background Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have
Minwen Zhou, Bing Lu, Wei Tan, Mingshui Fu   +3 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Exploring the Potential Key IncRNAs with Endometriosis by Construction of a ceRNA Network

International Journal of General Medicine, 2021
The etiology and pathophysiology of endometriosis remain unclear. Current research indicates long noncoding RNA (lncRNA) may play an important role in the pathogenesis and development of endometriosis. However, the molecular mechanism of lncRNA in endometriosis is far from clear.The lncRNA and mRNA expression of 8 patients with ovarian endometriosis ...
Gu,Chenglei, Meng,Yuanguang, Meng,Qingqing, Fan,Wensheng, Ye,Mingxia, Zhang,Qian, Zhang,Nina, Li,Lian   +7 more
openaire   +5 more sources

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

ceRNA network analysis reveals prognostic markers for glioblastoma

Oncology Letters, 2019
Glioblastoma (GBM) is a common aggressive cancer that originates in the brain, which has a poor prognosis. It is therefore crucial to understand its underlying genetic mechanisms in order to develop novel therapies. The present study aimed to identify some prognostic markers and candidate therapeutic targets for GBM.
Wang, Hao, Zhang, Heying, Zeng, Juan, Tan, Yonggang   +3 more
openaire   +3 more sources

Unveiling the immune-related ceRNA network in osteoarthritis: key biomarkers and therapeutic targets

Introduction The aim of this study was to explore the immune-related competitive endogenous RNA (ceRNA) network in osteoarthritis (OA), focusing on identifying differentially expressed long non-coding RNAs (lncRNAs), constructing a classification model ...
Xu Wang, Xin Ma, Wang, Xu, Ma, Xin, Jia-qi Shi, Li Chen, Shi, Jia-qi, Chen, Li   +7 more
core   +1 more source