Results 91 to 100 of about 29,499 (226)

Identification and validation of a novel glycolysis-related ceRNA network for sepsis-induced cardiomyopathy

Frontiers in Medicine
PurposeSepsis-induced cardiomyopathy (SIC) is a major life-threatening condition in critically infected patients. Early diagnosis and intervention are important to improve patient prognosis.
Lulu Cheng, Lulu Cheng, Jiabin Liang, Fangmei Xie, Zeping Han, Wenfeng Luo, Hanwei Chen, Jinhua He   +7 more
doaj   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

The regulatory mechanism of LncRNA-mediated ceRNA network in osteosarcoma

Scientific Reports, 2022
AbstractAberrantly expressed lncRNAs have been reported to be closely related to the oncogenesis and development of osteosarcoma. However, the role of a dysregulated lncRNA-miRNA-mRNA network in osteosarcoma in the same individual needs to be further investigated. Whole transcriptome sequencing was performed on the tumour tissues and matched paratumour
Chengsen Lin, Jifeng Miao, Juliang He, Wenyu Feng, Xianxiang Chen, Xiaohong Jiang, Jianhong Liu, Boxiang Li, Qian Huang, Shijie Liao, Yun Liu   +10 more
openaire   +3 more sources

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

BMC Ophthalmology, 2020
Background Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have
Minwen Zhou, Bing Lu, Wei Tan, Mingshui Fu   +3 more
doaj   +1 more source

Intrinsic noise of microRNA-regulated genes and the ceRNA hypothesis [PDF]

, 2013
MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic ...
Lang, Alex, Mehta, Pankaj, Noorbakhsh, Javad   +2 more
core   +3 more sources

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

The ceRNA network regulates epithelial-mesenchymal transition in colorectal cancer

Heliyon, 2023
Epithelial-mesenchymal transition (EMT) is a biological process that transforms epithelial cells into a mesenchymal phenotype, conferring cell migration and invasion capabilities. EMT is involved in the progression and metastasis of colorectal cancer (CRC). Recently, emerging evidence has shown dysregulation of non-coding RNA (ncRNA) was linked to EMT.
Ruina Li, Hui Xu, Xiaoling Gao
openaire   +3 more sources

Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information

BMC Genomics, 2019
Background A long noncoding RNA (lncRNA) can act as a competing endogenous RNA (ceRNA) to compete with an mRNA for binding to the same miRNA. Such an interplay between the lncRNA, miRNA, and mRNA is called a ceRNA crosstalk. As an miRNA may have multiple
Chaowang Lan, Hui Peng, Gyorgy Hutvagner, Jinyan Li   +3 more
doaj   +1 more source

A SpiNNaker Application: Design, Implementation and Validation of SCPGs [PDF]

, 2017
In this paper, we present the numerical results of the implementation of a Spiking Central Pattern Generator (SCPG) on a SpiNNaker board. The SCPG is a network of current-based leaky integrateand- fire (LIF) neurons, which generates periodic spike ...
Cuevas Arteaga, Brayan, Domínguez Morales, Juan Pedro, Espinal, Andrés, Gómez Rodríguez, Francisco de Asís, Jiménez Fernández, Ángel Francisco, Linares Barranco, Alejandro, Rostro González, Horacio   +6 more
core   +1 more source