Results 91 to 100 of about 4,583,316 (255)

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Supplementary Figure S5 from Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma

, 2023
Supplementary Figure S5. Characteristics of prognosis-related ceRNA network.
Dongliang Leng (17079663), Ka U. Ip (17079678), Qi Zhao (10053729), Heng Sun (17079669), Guokai Chen (14963870), Ziyi Yang (17079666), Xiaohua Douglas Zhang (9398052), Chengcheng Song (17079672), Chen Huang (17079675), Chu-Xia Deng (16721652)   +9 more
core   +1 more source

LINC01605 Predicts the Poor Prognosis of Non‐Small Cell Lung Cancer and Promotes Chemotherapy Resistance by Regulating miR‐7111‐5p/ELK1

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Non‐small cell lung cancer (NSCLC) is characterized by high incidence, mortality, and poor patient prognosis, with chemotherapy resistance being a common challenge. This research intends to identify key molecules involved in NSCLC and elucidate the regulatory role of the LINC01605/miR‐7111‐5p/ELK1 axis in chemotherapy resistance. LINC01605 and
Fang Zhang, Zhi‐Liang Yang, Tian‐Tian Qin, Guo‐Jun Zhang, Xiang Li   +4 more
wiley   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang, Hong‐Cheng Wei, Lin Jiang, Yi‐Sen Shao   +3 more
wiley   +1 more source

The tumor suppressor role and ceRNA network of miR-1294 in cancer

Oncology Research, 2023
miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells.
MAO, YUNAN, SHEN, JINZE, FANG, LI, ZHU, FENG, DUAN, SHIWEI   +4 more
openaire   +2 more sources

PPI network and visualization of ceRNA network.

, 2021
(A) STRING database was used to analyze the PPI network of 193 prognostic genes, and each node represented a distinct gene. (B) MCC algorithm was used to recognize hub-genes from PPI network, red and yellow nodes represented 8 hub-genes; (C, D) The ...
Zeng Fen (11250416), Jingrong Lin (180903), Yingming Chu (11250413), Qianyi Chen (6725840), Yuankuan Jiang (11250419), Nan Yang (305078), Shifeng Fang (3707584), Xueying Shi (11250410), Shilin Xia (250469), Jingyuan Zheng (7022564)   +9 more
core   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Identification of hub genes and potential ceRNA networks of diabetic cardiomyopathy

Scientific Reports, 2023
Abstract Diabetic cardiomyopathy (DCM), a common complication of diabetes, is defined as ventricular dysfunction in the absence of underlying heart disease. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in the development of DCM.
Jun Hou, Wan Yi Liang, Shiqiang Xiong, Pan Long, Tian Yue, Xudong Wen, Tianchen Wang, Haoyu Deng   +7 more
openaire   +3 more sources

Supplementary Figure S6 from Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma

, 2023
Supplementary Figure S6. Construction of subnetwork of prognosis-related ceRNA network.
Dongliang Leng (17079663), Ka U. Ip (17079678), Qi Zhao (10053729), Heng Sun (17079669), Guokai Chen (14963870), Ziyi Yang (17079666), Xiaohua Douglas Zhang (9398052), Chengcheng Song (17079672), Chen Huang (17079675), Chu-Xia Deng (16721652)   +9 more
core   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source