Results 111 to 120 of about 19,790 (218)

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

BMC Ophthalmology, 2020
Background Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have
Minwen Zhou, Bing Lu, Wei Tan, Mingshui Fu   +3 more
doaj   +1 more source

Integrated Transcriptomic and Functional Analyses Reveal lncRNA‐miRNA‐mRNA Axis in AML Relapse After Allo‐HSCT

Cancer Science, EarlyView.
Transcriptomic profiling of CD34+ cells from AML patients relapsing after allo‐HSCT reveals lncRNA‐driven ceRNA networks, with the SNHG8‐miR‐625‐ZC3H13/15 axis identified as a key relapse‐promoting module through CRISPR screening and single‐cell perturbation.
Fei Zhao, Wenhao Wang, Hongye Gao, Ping Zhu, Weihua Zhai, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Lina Wu, Shukai Qiao, Lei Zhang, Erlie Jiang, Xiaolei Pei, Donglin Yang   +14 more
wiley   +1 more source

Exploring the Potential Key IncRNAs with Endometriosis by Construction of a ceRNA Network

International Journal of General Medicine, 2021
The etiology and pathophysiology of endometriosis remain unclear. Current research indicates long noncoding RNA (lncRNA) may play an important role in the pathogenesis and development of endometriosis. However, the molecular mechanism of lncRNA in endometriosis is far from clear.The lncRNA and mRNA expression of 8 patients with ovarian endometriosis ...
Gu,Chenglei, Meng,Yuanguang, Meng,Qingqing, Fan,Wensheng, Ye,Mingxia, Zhang,Qian, Zhang,Nina, Li,Lian   +7 more
openaire   +5 more sources

Table_1_Systematic Characterization of Circular RNA-Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer's Disease.XLSX [PDF]

, 2019
Alzheimer's disease (AD), a degenerative disease of the central nervous system, is the most common form of dementia in old age. The complexity and behavior of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) network remained poorly ...
Fulong Yu (3398372), Yan Zhang (8098), Siqi Bao (3765430), Jie Sun (74648)   +3 more
core   +1 more source

Construction of a ceRNA network of regulated ferroptosis in doxorubicin-induced myocardial injury [PDF]

, 2023
Background Ferroptosis and long-noncoding RNAs (lncRNAs) play crucial roles in doxorubicin (DOX)-induced myocardial injury (DIMI). Nevertheless, there is no research to construct competing endogenous RNAs (ceRNAs) network between lncRNAs and ferroptosis ...
Lu Li, Hongwei Ye, Yuping Li, Qin Gao, Jiahui Wang, Yuhui Huang   +5 more
core   +1 more source

Elucidating the Pro‐Tumor Role of LncRNA CROCCP2 in Glioma via the miR‐5584‐5p/HOXD11/Autophagy Pathway

Cancer Science, EarlyView.
The lncRNA CROCCP2 upregulates HOXD11 by competitively adsorbing miR‐5584‐5p, thereby promoting glioma cell proliferation, migration, and invasion by inhibiting autophagy. It significantly enhances tumor growth in vivo, suggesting it may be a potential therapeutic target for gliomas.
Feng Wang, Ganni Lei, Yuan Peng, Maoqiao Liu, Tianqi Jiang, Minghui Wang, Zhe Wang, Jun Pu, Jia Liu   +8 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Comprehensive analysis of lncRNA-miRNA-mRNA ceRNA network in ischemic stroke

Heliyon
Objective: Competitive endogenous RNA (ceRNA) networks have uncovered a novel mode of RNA interaction, and are implicated in various biological processes and the pathogenesis of IS.
Lin Cheng, Yun Zhao, Hong Ke
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

The ceRNA network of lncRNAs–miRNAs–mRNAs and its functional analysis. [PDF]

(A) Sankey diagram for the ceRNA network in islets. Each rectangle represents a gene, and the connection degree of each gene is displayed based on the size of the rectangle. (B) A ceRNA visual network including 38 DE mRNAs, 15 DE lncRNAs, and 7 DE miRNAs.
Rui Gao (247606), Jinfang Ma (38894), Qingxing Xie (18283785), Xiaohui Pan (1979788), Nanwei Tong (3349547)   +4 more
core   +1 more source