Individualization of Treatments with Drugs Metabolized by CES1: Combining Genetics and Metabolomics
Pharmacogenomics, 2015CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic compounds including several essential and commonly used drugs. The individual variation in the efficacy and tolerability of many drugs metabolized by CES1 is considerable. Hence, there is a large interest in individualizing the treatment with these drugs. The present
Rasmussen, H.B. +18 more
openaire +4 more sources
Presence and inter-individual variability of carboxylesterases (CES1 and CES2) in human lung
Biochemical Pharmacology, 2018Lungs are pharmacologically active organs and the pulmonary drug metabolism is of interest for inhaled drugs design. Carboxylesterases (CESs) are enzymes catalyzing the hydrolysis of many structurally different ester, amide and carbamate chemicals, including prodrugs.
Gabriele Morena +5 more
openaire +4 more sources
Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009Mouse esterase-x/carboxylesterase 1 (Es-x/Ces1) is a close homolog of triacylglycerol hydrolase/carboxylesterase 3 (TGH/Ces3). Es-x possesses a conserved esterase/lipase active site motif, suggesting that like TGH it could play a role in hepatic triacylglycerol (TG) metabolism.
Kerry W S, Ko +2 more
openaire +2 more sources
Pharmacogenetic study of CES1 gene and enalapril efficacy
Journal of Applied GeneticsEnalapril is an orally administered angiotensin-converting enzyme inhibitor which is widely prescribed to treat hypertension, chronic kidney disease, and heart failure. It is an ester prodrug that needs to be activated by carboxylesterase 1 (CES1). CES1 is a hepatic hydrolase that in vivo biotransforms enalapril to its active form enalaprilat in order ...
Misbah Hussain +5 more
openaire +2 more sources
Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018Obesity often leads non-alcoholic fatty liver disease, insulin resistance and hyperlipidemia. Expression of carboxylesterase CES1 is positively correlated with increased lipid storage and plasma lipid concentration. Here we investigated structural and metabolic consequences of a single nucleotide polymorphism in CES1 gene that results in p.Gly143Glu ...
Jihong, Lian +8 more
openaire +2 more sources
Carboxylesterase 1 (Ces1): from monocyte marker to major player
Journal of Clinical Pathology, 2010There are few, if any, enzymes that have been studied by, and have importance in, so many and varied disciplines as has monocyte esterase/Ces 1. In this review its involvement in the fields of histochemistry, haematology, toxicology, pharmacology, therapeutics, and tumour cell killing, immune surveillance and malignant disease, is briefly described.
openaire +2 more sources
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
Drug Metabolism and Drug Interactions, 2014Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Several common genetic variants of the CES1 and CES2
Zahra, Merali +2 more
openaire +2 more sources
Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1
EMBO Reports, 2023Yuchen Chen, Kun Huang, Junqiu Yue
exaly