Results 171 to 180 of about 3,332 (192)
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Human Carboxylesterases: An Update on CES1, CES2 and CES3
Protein & Peptide Letters, 2009Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a variety of drug esters, amides, carbamates and similar structures. There are five 'carboxylesterase' genes listed in the Human Genome Organization database. In this review, we will focus on the CES1, CES2 and CES3 genes and their protein products that have been ...
Sonal P, Sanghani +3 more
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European Journal of Clinical Pharmacology, 2012
The aim of this study was to examine whether carboxylesterase 1 (CES1A) genetic polymorphisms affect the pharmacokinetics of oseltamivir.Thirty healthy Japanese male and female subjects ranging in age from 20 to 36 years voluntarily participated in this study.
Yuki, Suzaki +11 more
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The aim of this study was to examine whether carboxylesterase 1 (CES1A) genetic polymorphisms affect the pharmacokinetics of oseltamivir.Thirty healthy Japanese male and female subjects ranging in age from 20 to 36 years voluntarily participated in this study.
Yuki, Suzaki +11 more
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Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009Mouse esterase-x/carboxylesterase 1 (Es-x/Ces1) is a close homolog of triacylglycerol hydrolase/carboxylesterase 3 (TGH/Ces3). Es-x possesses a conserved esterase/lipase active site motif, suggesting that like TGH it could play a role in hepatic triacylglycerol (TG) metabolism.
Kerry W S, Ko +2 more
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Pharmacogenetic study of CES1 gene and enalapril efficacy
Journal of Applied GeneticsEnalapril is an orally administered angiotensin-converting enzyme inhibitor which is widely prescribed to treat hypertension, chronic kidney disease, and heart failure. It is an ester prodrug that needs to be activated by carboxylesterase 1 (CES1). CES1 is a hepatic hydrolase that in vivo biotransforms enalapril to its active form enalaprilat in order ...
Misbah Hussain +5 more
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Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018Obesity often leads non-alcoholic fatty liver disease, insulin resistance and hyperlipidemia. Expression of carboxylesterase CES1 is positively correlated with increased lipid storage and plasma lipid concentration. Here we investigated structural and metabolic consequences of a single nucleotide polymorphism in CES1 gene that results in p.Gly143Glu ...
Jihong, Lian +8 more
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Carboxylesterase 1 (Ces1): from monocyte marker to major player
Journal of Clinical Pathology, 2010There are few, if any, enzymes that have been studied by, and have importance in, so many and varied disciplines as has monocyte esterase/Ces 1. In this review its involvement in the fields of histochemistry, haematology, toxicology, pharmacology, therapeutics, and tumour cell killing, immune surveillance and malignant disease, is briefly described.
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The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
Drug Metabolism and Drug Interactions, 2014Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Several common genetic variants of the CES1 and CES2
Zahra, Merali +2 more
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Bioorganic Chemistry
Carboxylesterase 1 (CES1), a member of the serine hydrolase superfamily, is involved in a wide range of xenobiotic and endogenous substances metabolic reactions in mammals. The inhibition of CES1 could not only alter the metabolism and disposition of related drugs, but also be benefit for treatment of metabolic disorders, such as obesity and fatty ...
Dan-Dan Wang +7 more
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Carboxylesterase 1 (CES1), a member of the serine hydrolase superfamily, is involved in a wide range of xenobiotic and endogenous substances metabolic reactions in mammals. The inhibition of CES1 could not only alter the metabolism and disposition of related drugs, but also be benefit for treatment of metabolic disorders, such as obesity and fatty ...
Dan-Dan Wang +7 more
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Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1
EMBO Reports, 2023Dong Yang, Mingrui Xiong, Yuchen Chen
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