Results 171 to 180 of about 6,102 (207)

Pharmacometabolomics Detects Unreported Clopidogrel Metabolites in the Urine of Kidney and Liver Transplant Recipients. [PDF]

Metabolites
Piccolotto C, Bakker SJL, de Meijer VE, Hopfgartner G, Fodran P, Klont F, TransplantLines Investigators.   +6 more
europepmc   +1 more source

Abstract 2073 KNOCKDOWN OF CES1 IN THP-1 MACROPHAGES PROMOTES A PROINFLAMMATORY PHENOTYPE

Journal of Biological Chemistry
Oluwabori Adekanye, Abdolsamad Borazjani, Matthew Ross   +2 more
openaire   +1 more source

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Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation

European Journal of Clinical Pharmacology, 2012
Carboxylesterase 1 (CES1) is the major hepatic hydrolytic enzyme responsible for the metabolism of many therapeutic agents, toxins, and endogenous compounds existing as esters, amides, thioesters, and carbamates. CES1 is coded by the CES1 gene in humans, which consists of three isoforms: CES1A1, CES1A2, and CES1A3.
Hao-Jie Zhu
exaly   +3 more sources

Natural Products as Modulators of CES1 Activity

Drug Metabolism and Disposition, 2020
Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 ...
Yuli Qian, John S. Markowitz
openaire   +2 more sources

Human Carboxylesterases: An Update on CES1, CES2 and CES3

Protein & Peptide Letters, 2009
Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a variety of drug esters, amides, carbamates and similar structures. There are five 'carboxylesterase' genes listed in the Human Genome Organization database. In this review, we will focus on the CES1, CES2 and CES3 genes and their protein products that have been ...
Sonal P, Sanghani, Paresh C, Sanghani, Marissa A, Schiel, William F, Bosron   +3 more
openaire   +2 more sources

Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009
Mouse esterase-x/carboxylesterase 1 (Es-x/Ces1) is a close homolog of triacylglycerol hydrolase/carboxylesterase 3 (TGH/Ces3). Es-x possesses a conserved esterase/lipase active site motif, suggesting that like TGH it could play a role in hepatic triacylglycerol (TG) metabolism.
Kerry W S, Ko, Bruce, Erickson, Richard, Lehner   +2 more
openaire   +2 more sources

Carbonate‐Based Fluorescent Chemical Tool for Uncovering Carboxylesterase 1 (CES1) Activity Variations in Live Cells

ChemBioChem, 2022
AbstractCarboxylesterase 1 (CES1) plays a key role in the metabolism of endogenous biomolecules and xenobiotics including a variety of pharmaceuticals. Despite the established importance of CES1 in drug metabolism, methods to study factors that can vary CES1 activity are limited with only a few suitable for use in live cells.
Anchal Singh, Mingze Gao, Carolyn J. Karns, Taylor P. Spidle, Michael W. Beck   +4 more
openaire   +2 more sources

Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018
Obesity often leads non-alcoholic fatty liver disease, insulin resistance and hyperlipidemia. Expression of carboxylesterase CES1 is positively correlated with increased lipid storage and plasma lipid concentration. Here we investigated structural and metabolic consequences of a single nucleotide polymorphism in CES1 gene that results in p.Gly143Glu ...
Jihong, Lian, Wesam, Bahitham, Rashmi, Panigrahi, Randal, Nelson, Lena, Li, Russell, Watts, Aducio, Thiesen, M Joanne, Lemieux, Richard, Lehner   +8 more
openaire   +2 more sources