Results 161 to 170 of about 3,332 (192)

Sex-related differences in blood concentrations and emergence profiles following total intravenous anesthesia with remimazolam and remifentanil. [PDF]

Sci Rep
Sato R, Higuchi H, Nishioka Y, Miyake S, Miyawaki T.   +4 more
europepmc   +1 more source

The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension

Journal of Personalized Medicine, 2022
The angiotensin-converting enzyme inhibitor enalapril is hydrolysed to an active metabolite, enalaprilat, in the liver via carboxylesterase 1 (CES1). Previous studies show that variant rs71647871 in the CES1 gene affects the pharmacokinetics of enalapril on liver samples as well as healthy volunteers.
Anna Ikonnikova, Tatiana Nasedkina
exaly   +4 more sources

The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC

Genes, 2023
Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify the influence of polymorphisms of the genes encoding P-glycoprotein (ABCB1) and ...
Ainur Akilzhanova, Akilzhanova Ainur
exaly   +2 more sources

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Natural Products as Modulators of CES1 Activity

Drug Metabolism and Disposition, 2020
Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 ...
Yuli Qian, John S. Markowitz
openaire   +2 more sources

Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation

European Journal of Clinical Pharmacology, 2012
Carboxylesterase 1 (CES1) is the major hepatic hydrolytic enzyme responsible for the metabolism of many therapeutic agents, toxins, and endogenous compounds existing as esters, amides, thioesters, and carbamates. CES1 is coded by the CES1 gene in humans, which consists of three isoforms: CES1A1, CES1A2, and CES1A3.
Hao-Jie Zhu, Zhu Hao-Jie
exaly   +3 more sources

An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1)

Chemico-Biological Interactions, 2023
Kratom, (Mitragyna Speciosa Korth.) is a plant indigenous to Southeast Asia whose leaves are cultivated for a variety of medicinal purposes and mostly consumed as powders or tea in the United States. Kratom use has surged in popularity with the lay public and is currently being investigated for possible therapeutic benefits including as a treatment for
Philip W Melchert, Sushobhan Mukhopadhyay, Siva Rama Raju Kanumuri   +2 more
exaly   +3 more sources