Results 161 to 170 of about 3,685 (179)

Carboxylesterase 1 (Ces1): from monocyte marker to major player

Journal of Clinical Pathology, 2010
There are few, if any, enzymes that have been studied by, and have importance in, so many and varied disciplines as has monocyte esterase/Ces 1. In this review its involvement in the fields of histochemistry, haematology, toxicology, pharmacology, therapeutics, and tumour cell killing, immune surveillance and malignant disease, is briefly described.
openaire   +2 more sources

The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect

Drug Metabolism and Drug Interactions, 2014
Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Several common genetic variants of the CES1 and CES2
Zahra, Merali, Stephanie, Ross, Guillaume, Paré   +2 more
openaire   +2 more sources

Pyrazolone compounds could inhibit CES1 and ameliorates fat accumulation during adipocyte differentiation

Bioorganic Chemistry
Carboxylesterase 1 (CES1), a member of the serine hydrolase superfamily, is involved in a wide range of xenobiotic and endogenous substances metabolic reactions in mammals. The inhibition of CES1 could not only alter the metabolism and disposition of related drugs, but also be benefit for treatment of metabolic disorders, such as obesity and fatty ...
Dan-Dan Wang, Zhen-Zhen Wang, Wen-Cai Liu, Xing-Kai Qian, Ya-Di Zhu, Tie-Gang Wang, Shu-Mei Pan, Li-Wei Zou   +7 more
openaire   +2 more sources

Loss of Renal Tubular G9a Benefits Acute Kidney Injury by Lowering Focal Lipid Accumulation via CES1

EMBO Reports, 2023
Yuchen Chen, Kun Huang, Junqiu Yue
exaly  

Effect of CES1 Genetic Variation on Enalapril Steady-State Pharmacokinetics and Pharmacodynamics in Healthy Subjects

British Journal of Clinical Pharmacology, 2021
Xinwen Wang, Hao-Jie Zhu, Barry E Bleske
exaly  

Hormetic Effects of EGC and EGCG on CES1 Activity and Its Rescue From Oxidative Stress in Rat Liver S9

Chemico-Biological Interactions, 2023
Hongjian Zhang, Zhiyun Zhou, Xiaoting Luo   +2 more
exaly  

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics and Pharmacodynamics in Patients With Atrial Fibrillation

British Journal of Clinical Pharmacology, 2021
Qianzhou Lv, Qianzhou Lv, Qing Xu
exaly  

A Comprehensive Functional Assessment of CES1 Nonsynonymous Variants

The FASEB Journal, 2017
Xinwen Wang, Nada Rida, Jian Shi, Hao‐Jie Zhu   +3 more
openaire   +1 more source

The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium With the Intronic rs2244613

Genes, 2022
Tatiana Nasedkina, Anna Ikonnikova, Evgeny S Melnikov   +2 more
exaly  

Reappraisal of the Genetic Diversity and Pharmacogenetic Assessment of CES1

Pharmacogenomics, 2017
Gesche Jurgens, Kim Peder Dalhoff, Majbritt B. Madsen   +2 more
exaly