Results 11 to 20 of about 15,331 (173)

Xanthohumol prevents atherosclerosis by reducing arterial cholesterol content via CETP and apolipoprotein E in CETP-transgenic mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Xanthohumol is expected to be a potent anti-atherosclerotic agent due to its inhibition of cholesteryl ester transfer protein (CETP). In this study, we hypothesized that xanthohumol prevents atherosclerosis in vivo and used CETP-transgenic ...
Hiroshi Hirata, Yimin, Shuichi Segawa, Moeko Ozaki, Naoyuki Kobayashi, Tatsuro Shigyo, Hitoshi Chiba   +6 more
doaj   +2 more sources

CETP inhibitor evacetrapib enters mouse brain tissue [PDF]

Frontiers in Pharmacology, 2023
High levels of plasma cholesterol, especially high levels of low-density lipoprotein cholesterol (LDL-C), have been associated with an increased risk of Alzheimer’s disease.
Jasmine Phénix, Jasmine Phénix, Jonathan Côté, Jonathan Côté, Denis Dieme, Denis Dieme, Sherilyn J. Recinto, Sherilyn J. Recinto, Sherilyn J. Recinto, Felix Oestereich, Felix Oestereich, Felix Oestereich, Sasen Efrem, Sasen Efrem, Sami Haddad, Sami Haddad, Michèle Bouchard, Michèle Bouchard, Lisa Marie Munter, Lisa Marie Munter, Lisa Marie Munter   +20 more
doaj   +2 more sources

Targeting the CTBP1-CETP axis overcomes ferroptosis resistance in non-small cell lung cancer by altering lipid accumulation. [PDF]

Clin Transl Med
CTBP1‐driven CETP activation orchestrates lipid accumulation to suppress MAPK‐dependent ferroptosis in non‐small cell lung cancer. Repurposing the clinical‐stage CETP inhibitor obicetrapib successfully overcomes this resistance in NSCLC patient‐derived organoids, highlighting a promising translational therapeutic strategy. Abstract Background Non‐small
Chen Y, Wang H, Tan X, Yan C, Liu F, Deng S, Wang C, Xia Y, Xu Z, Wu K, Huang S, Chu Q.   +11 more
europepmc   +2 more sources

Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo. [PDF]

Acta Physiol (Oxf)
ABSTRACT Free fatty acids (FFAs) are hydrophobic and therefore cannot enter the bloodstream at appreciable levels unless they are solubilized by FFA carriers. Albumin has been appreciated for years as the major FFA carrier, but it is not the only carrier.
Henderson GC, Buhman KK, Tomoo K.
europepmc   +2 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

CETP IN RARE DYSLIPIDEMIAS

, 2009
Objective: To determines CETP mass and activity in rare disorders of HDL metabolism. Methods: Patients: Fasting plasma samples were obtained from two individuals with TD and from patients with LCAT deficiency, analphalipoproteinemia, Hepatic lipase ...
Sachs-Barrable, K, Hill, J, Wasan, K, Frohlich, J, Al-Sarraf, A   +4 more
core   +4 more sources

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Chaitman Bernard R., Nicholls, Stephen J., Mundl, Hardi,, Ballantyne, Christie M,, Nicholls, Stephen J,, Ballantyne, Christie M., Shah, P.K., Ballantyne Christie M., Ballantyne C.M., Chaitman B.R., Wright, R Scott,, McMurray, J.J.V., McMurray, John J V, Mundl, H., Abt Markus, Shah, Prediman K., Schwartz, G.G., McMurray, John J. V., Leiter, Lawrence A,, Leiter, Lawrence A., Barter, Philip J., DE CATERINA, Raffaele, Tardif, Jean-Claude,, Barter, P.J., Leiter L.A., McMurray, J., Brumm, J., Wright, R Scott, Olsson, A.G., Abt, Markus,, Shah Prediman K., dal OUTCOMES Investigators, Leitersdorf, E., Ballantyne, C.M., Kallend, David,, Brumm, Jochen, Mundl Hardi, Shah, Prediman K,, Holme, Ingar M., McMurray, John J V,, Holme, Ingar M,, Brumm Jochen, McMurray J.J., Kallend, David, Goldner, David, Wright, R., Tardif, J., Chaitman, Bernard R,, Wright R. Scott, Shah, P., Chaitman, Bernard R., Chaitman, B., Kallend David, Nicholls, Stephen J, Schwartz Gregory G., Barter, Philip J,, Leiter Lawrence A., Tardif, Jean-Claude, Barter P.J., Barter, P., Abt, Markus, Schwartz, Gregory G., Leiter, Lawrence A, Holme I.M., Olsson, A., The dal-OUTCOMES Investigators, Tardif Jean Claude, Holme, Ingar M, Leitersdorf, Eran, Wright, R.S., Barter Philip J., Schwartz, Gregory G,, Olsson Anders G., Leiter, L.A., Olsson A.G., Olsson, Anders G., Schwartz, Gregory G, Colquhoun, David, Leiter, L., Nicholls, S.J., Barter, Philip J, Chaitman, Bernard R, Brumm, Jochen,, Leitersdorf E., Nicholls, S., Chaitman, B.R., Holme, I.M., Holme, I., Kallend, D., Brumm J., Mundl, Hardi, Shah, Prediman K, Nicholls Stephen J., Wright, R. Scott, McMurray John J. V., Kallend D., Olsson, Anders,, Ballantyne, C., Holme Ingar M., Olsson, Anders G, Abt M., Schwartz G.G., Leitersdorf Eran, Abt, M., Ballantyne, Christie M, Schwartz, G., Leitersdorf, Eran,, GOLINO, Paolo   +107 more
core   +1 more source

Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome [PDF]

, 2011
Background Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).
Boer, J.M., Dollé Martijn ET, Boer Jolanda MA, Feskens Edith JM, Martijn ET Dollé, Edith JM Feskens, Imholz, S., Feskens, E.J.M., Sandra Imholz, Povel, C.M., Cécile M Povel, Jolanda MA Boer, Imholz Sandra, Povel Cécile M, Dolle, M.E.   +14 more
core   +1 more source

CETP Deficiency and Concerns in CETP Inhibitor Development [PDF]

, 2017
Although some CETP-lowering SNPs in the CETP gene are variably associated with improved clinical outcomes in patients with coronary artery disease (CAD), three low molecular weight oral CETP inhibitors (torcetrapib, dalcetrapib, and evacetrapib) have not
Akihiro Inazu, Inazu, Akihiro, 80293348, 539   +3 more
core   +1 more source

On the incidence of Kelvin-Helmholtz instability for mass exchange process at the Earth’s magnetopause [PDF]

Annales Geophysicae, 2002
Due to the velocity shear imposed by the solar wind flowing around the magnetosphere, the magnetopause flanks are preferred regions for the development of a Kelvin-Helmholtz instability.
R. Smets, R. Smets, R. Smets, D. Delcourt, G. Chanteur, T. E. Moore   +5 more
doaj   +1 more source