Results 31 to 40 of about 15,331 (173)

Allelic variation in the gene encoding the cholesteryl ester transfer protein is associated with variation in the plasma concentrations of cholesteryl ester transfer protein.

Journal of Lipid Research, 1996
The cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from high density lipoproteins (HDL) to triglyceride-rich lipoproteins. Mutations that abolish CETP function are associated with very high levels of HDL cholesterol,
R McPherson, S M Grundy, R Guerra, J C Cohen   +3 more
doaj   +1 more source

Low‐density lipoprotein receptor is required for cholesteryl ester transfer protein to regulate triglyceride metabolism in both male and female mice

Physiological Reports, 2021
Elevated triglycerides (TGs) and impaired TG clearance increase the risk of cardiovascular disease in both men and women, but molecular mechanisms remain poorly understood.
Brian T. Palmisano, Sophia Yu, Joshua C. Neuman, Lin Zhu, Thao Luu, John M. Stafford   +5 more
doaj   +1 more source

CETP Inhibition: Past Failures and Future Hopes

, 2016
The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease has been unequivocally established, and epidemiological data have clearly demonstrated a strong inverse relationship between HDL-C levels and the risk of ...
Eddy DeJesus, Timothy J. Vittorio, Constantine E. Kosmas, Digna Rosario   +3 more
core   +1 more source

Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice

Journal of Lipid Research, 2003
Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is ...
Patrícia M. Cazita, Jairo A. Berti, Carolina Aoki, Magnus Gidlund, Lila M. Harada, Valéria S. Nunes, Eder C.R. Quintão, Helena C.F. Oliveira   +7 more
doaj   +1 more source

Cholesteryl ester transfer protein (CETP) mRNA abundance in human adipose tissue: relationship to cell size and membrane cholesterol content.

Journal of Lipid Research, 1995
Cholesteryl ester transfer protein (CETP) has a well-defined role in plasma neutral lipid transport. CETP synthesized by human adipose tissue may contribute to the plasma CETP pool. CETP mRNA abundance increases in subcutaneous adipose tissue in response
T Radeau, P Lau, M Robb, M McDonnell, G Ailhaud, R McPherson   +5 more
doaj   +1 more source

Lipid transfer activity, secretion, and synthesis of CETP missense variants.

, 2023
HEK293 cells were transiently transfected with the WT-CETP plasmid or the indicated CETP plasmids. (A) The lipid transfer activities in the media of transfected cells were determined. To account for the number of cells in the lysate secreting CETP, lipid
Åsa Schawlann Ølnes (17537519), Marianne Teigen (17537522), Trond P. Leren (14223497), Jon K. Laerdahl (7840751), Katrine Bjune (6858293), Thea Bismo Strøm (17537525)   +5 more
core   +1 more source

The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study

Biomedicines, 2021
The impact of cholesteryl ester transfer protein (CETP) on atherosclerosis is highly debated. This study aimed to investigate the associations between plasma CETP or CETP genotypes and carotid intima-media thickness (cIMT) and the influence of high ...
Gualtiero I. Colombo, Vanessa Bianconi, Alice Bonomi, Sara Simonelli, Mauro Amato, Beatrice Frigerio, Alessio Ravani, Cecilia Vitali, Daniela Sansaro, Daniela Coggi, Massimo R. Mannarino, Kai P. Savonen, Sudhir Kurl, Bruna Gigante, Andries J. Smit, Philippe Giral, Elena Tremoli, Laura Calabresi, Fabrizio Veglia, Matteo Pirro, Damiano Baldassarre, on behalf of the IMPROVE Study Group   +21 more
doaj   +1 more source

Sex-Specific Effects of Cholesteryl Ester Transfer Protein (CETP) on the Perivascular Adipose Tissue

Function
Cholesteryl ester transfer protein (CETP) increases the atherosclerosis risk by lowering HDL-cholesterol levels. It also exhibits tissue-specific effects independent of HDL. However, sexual dimorphism of CETP effects remains largely unexplored.
C M Lazaro, I N Freitas, V S Nunes, D M Guizoni, J A Victorio, H C F Oliveira, A P Davel   +6 more
doaj   +1 more source

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase

Journal of Lipid Research, 2008
Human atherosclerotic intima contains mast cells that secrete the neutral protease chymase into the intimal fluid, which also contains HDL-modifying proteins, such as cholesteryl ester transfer protein (CETP), in addition to abundant amounts of nascent ...
Miriam Lee-Rueckert, Riikka Vikstedt, Jari Metso, Matti Jauhiainen, Petri T. Kovanen   +4 more
doaj   +1 more source

Large-scale distributions of ionospheric horizontal and field-aligned currents inferred from EISCAT [PDF]

Annales Geophysicae, 1996
Statistical models for large-scale convection and for ionospheric conductances were previously derived from observations of the incoherent-scatter radar EISCAT.
D. Fontaine, C. Peymirat
doaj   +1 more source