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Plasma cfDNA predictors of established bacteraemic infection

Access Microbiology, 2022
Introduction. Increased plasma cell-free DNA (cfDNA) has been reported for various diseases in which cell death and tissue/organ damage contribute to pathogenesis, including sepsis. Gap Statement. While several studies report a rise in plasma cfDNA in bacteraemia and sepsis, the main source of cfDNA ...
Nadia Urosevic, Timothy J J Inglis, Adam J Merritt   +2 more
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Electrokinetic separation of cfDNA in insulator-based dielectrophoresis systems: a linear model of cfDNA and investigation of effective parameters

Journal of Physics: Condensed Matter, 2022
Abstract In this study, a comprehensive numerical simulation was done to investigate the electrokinetic translocation of cfDNA molecule as well as the possibility of its detection and separation in insulator based dielectrophoresis (iDEP) systems.
Azita Abdollahi, Hossein Shokouhmand
openaire   +2 more sources

Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics

Frontiers in Genetics
Cell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications. From methylation patterns and fragmentation profiles to genetic variants, cfDNA holds immense potential for diagnosing and ...
Hong Qi, Yang Du, Jian Jiang Zhu
exaly   +4 more sources

Closing in on cfDNA-based detection and diagnosis

Nature Reviews Cancer, 2020
Two papers in Nature Medicine report studies that validate the utility of cell-free methylated DNA analysis for early detection of renal cell carcinomas and diagnosis of central nervous system tumours.
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cfDNA detection for HPV+ squamous cell carcinomas

Oral Oncology, 2021
High-risk human papillomavirus (HPV) is an etiologic factor in a spectrum of squamous cell carcinomas including anal, cervical, and oropharyngeal. HPV cell free DNA (cfDNA) is shed from the primary tumor into systemic circulation and can be detected using several platforms including quantitative PCR, digital droplet PCR, or next generation sequencing ...
Kate, Chatfield-Reed, Veronique P, Roche, Quintin, Pan   +2 more
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Assessing HER2 Amplification in Plasma cfDNA

2018
Digital PCR (dPCR) is a highly accurate method to determine DNA concentration. In dPCR, DNA is portioned into many discrete single entities, and these are analyzed individually for the presence or absence of a target molecule of interest. Here we describe how digital PCR can be employed to determine the presence of oncogenic amplification through ...
Garcia-Murillas, I, Turner, NC
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From cfDNA to Sequencing: Workflows and Potentials

2018
Cell-free DNA (cfDNA) is acquiring increasingly importance in oncologic clinical practice, mostly due to its role in predicting the onset of therapy resistance by following the mutation status changes of patients. In this field, high-sensitivity methods like next-generation sequencing (NGS) could help to accurately detect somatic mutations at low ...
Michela, Tebaldi, Samanta, Salvi
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Kidney cfDNA

The samples contain genomic sequencing data of cfDNA from healthy individuals and those with kidney disease.
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cfDNA kao biomarker [PDF]

, 2017
Since the discovery of cfDNA (cell-free DNA), many of its applications in molecular medicine have been considered and researched: from diagnosing and monitoring tumors, and predicting disease outcome using specific biomarkers, to the detection and prediction of aberrant fetus development using noninvasive prenatal diagnostics.
openaire  

lung cancer cfDNA

whole genome sequencing of lung cancer ...
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