Results 111 to 120 of about 34,737 (190)

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]

, 2017
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J., Cumberworth, Stephanie, Donald, Claire L., Kohl, Alain   +3 more
core   +1 more source

RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth

Cell Death Discovery
Cyclic guanosine-adenosine monophosphate synthase (cGAS) is a key cytosolic DNA sensor that plays a pivotal role in the innate immune response. Although a decade of research on the cGAS has advanced our understanding of inflammasome formation, cytokine ...
Weidong Chen, Ga-Eun Lee, Dohyun Jeung, Jiin Byun, Juan Wu, Xianzhe Li, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Kwang Dong Kim, Soo-Bin Nam, Cheol-Jung Lee, Young Jik Kwon, Yong-Yeon Cho   +13 more
doaj   +1 more source

SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang, Min Chu, Li-na Yan, Wen-kang Zhang, Bang Li, Jiao Xu, Zhong-xin Zhao, Hui-Ju Han, Chuan-min Zhou, Xue-jie Yu   +9 more
doaj   +1 more source

Prevailing dust-transport directions on comet 67P/Churyumov-Gerasimenko

, 2015
Dust transport and deposition behind larger boulders on the comet 67P/Churyumov-Gerasimenko (67P/C-G) have been observed by the Rosetta mission. We present a mechanism for dust transport vectors based on a homogenous surface activity model incorporating ...
Kramer, Tobias, Noack, Matthias
core   +1 more source

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]

, 2019
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato, Flavia Mulè, Simona Terzo   +2 more
core   +1 more source

Length does matter for cGAS

EMBO reports, 2017
Recognition of foreign nucleic acids by the immune system is essential to host protection against many viral and bacterial infections. It relies on the capacity of innate immune sensors to selectively distinguish self‐ and non‐self‐nucleic acids, on the basis of a variety of parameters including base modifications, sequence composition, length or ...
Michael P. Gantier, Michael P. Gantier
openaire   +3 more sources

SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]

, 2019
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E, Garelis, Nick E, Gowen, Benjamin G, Katibah, George E, Luteijn, Rutger D, McWhirter, Sarah M, Onia, Liberty, Raulet, David H, Woodward, Joshua J, Wyman, Stacia K, Zaver, Shivam A   +10 more
core  

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes [PDF]

, 2017
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).
A Ablasser, A Dempsey, AM Herzner, B Zhong, CD Conrady, CK Holm, D Cuchet-Lourenço, D Gao, DL Burdette, EE Gray, FO Nestle, G Yi, GC Carter, GL Smith, H Ishikawa, H Ishikawa, H Konno, J Rehwinkel, J Zhang, K Hansen, K Mukai, KA Horan, KL Jønsson, KM Storek, KMJ Sparrer, L Li, L Strähle, L Sun, L Unterholzner, L Unterholzner, L Zhang, M Kalamvoki, MH Orzalli, MH Orzalli, MR Jakobsen, MR Thompson, N Dobbs, Q Wang, RD Everett, S Chiliveru, S Liu, T Jin, T Li, T Saitoh, T Tsuchida, V Hornung, X Cai, X Zhang, X-D Li, Y Okabe, Y Wang, Z Li, Z Zhang   +52 more
core   +5 more sources

The polyphenolic and hydroxycinnamate contents of whole coffee fruits from China, India and Mexico [PDF]

, 2013
Air dried whole coffee fruits, beans and husks from China, India and Mexico were analysed for their chlorogenic acids (CGA), caffeine, and polyphenolic content. Analysis was by HPLC and Orbitrap exact mass spectrometry.
Combet, E., Mullen, W., Nemzer, B., Sidrah, A., Stalmach, A.   +4 more
core   +1 more source

A Multiphase Model for the Intracluster Medium [PDF]

, 1999
Constraints on the clustered mass density \Omega_m of the universe derived from the mean intracluster gas fraction of X-ray clusters may be biased by a single-phase assumption for the thermodynamic structure of the intracluster medium (ICM). We propose a
A. E. Evrard, Birkinshaw M., Cavaliere A., Cen R., Cole S., D. Nagai, David L. P., Eke V. R., Fabian A. C., Frenk C. S., Gunn K. F., Hamuy M., Inagaki Y., Irwin J. A., Irwin J. A., Jones M., M. E. Sulkanen, Mohr J. J., Navarro J. F., Neumann D. M., Nulsen P. E. J., Peres C. B., Raymond J. C., Riess A. G., Thomas P., Thomas P. A., White D. A., White S. D. M., Zaroubi S.   +28 more
core   +3 more sources