Results 131 to 140 of about 34,737 (190)
Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa
iScience, 2021 Summary: Cyclic GMP-AMP synthase (cGAS) is reported essential for detecting intracellular bacteria. However, it remains to be determined whether and how cGAS is involved in extracellular bacterial infection.
Chuan-min Zhou +7 more
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Cell Reports, 2023 Summary: As a key dsDNA recognition receptor, cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) plays a vital role in innate immune responses. Activated cGAS, by sensing DNA, catalyzes the synthesis of the secondary messenger cyclic GMP-AMP (cGAMP)
Jie Zhang +10 more
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Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest
Cardiovascular Innovations and ApplicationsCardiac dysfunction is a prevalent and serious complication after cardiac arrest (CA), yet limited therapeutic interventions are available. Cyclic GMP-AMP synthase (cGAS), a critical mediator of innate immune responses, has recently been identified as a ...
Ruiyu Wang +4 more
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cGAS-STING targeting offers therapy choice in lung diseases
Biology DirectCyclic GMP/AMP (cGAMP) synthase (cGAS), along with the endoplasmic reticulum (ER)-associated stimulator of interferon genes (STING), are crucial elements of the type 1 interferon response.
Yu Wang +5 more
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Regulation of the cGAS-STING Pathway
Annual Review of ImmunologyThe cGAS-cGAMP-STING pathway is essential for immune defense against pathogens. Upon binding DNA, cGAS synthesizes cGAMP, which activates STING, leading to potent innate immune effector responses. However, lacking specific features to distinguish between self and nonself DNA, cGAS-STING immunity requires precise regulation to prevent aberrant ...
Bing, Zhang +2 more
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Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity
iScience, 2020 Summary: cGAS/STING signaling plays an essential role in sensing cytosolic DNA. cGAS activity is regulated by posttranslational modifications and binding partners. cGAS interactome largely includes mammalian or viral proteins.
Yanqiong Zhang +13 more
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Nucleic acid sensors and programmed cell death [PDF]
, 2020 Liverpool, Layal +2 more
core +2 more sources
BMC CancercGAS plays an important role in regulating both tumor immune responses and DNA damage repair. Nevertheless, there was little research that comprehensively analyzed the correlation between cGAS and the tumor microenvironment, immune cell infiltration, and
Zhen Lian, Xue Liu, Xue Li
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Mitophagy and cGAS–STING crosstalk in neuroinflammation
Acta Pharmaceutica Sinica BMitophagy, essential for mitochondrial health, selectively degrades damaged mitochondria. It is intricately linked to the cGAS-STING pathway, which is crucial for innate immunity. This pathway responds to mitochondrial DNA and is associated with cellular stress response.
Xiaogang Zhou +8 more
openaire +3 more sources
A New Algorithm Cga For Image Labeling
, 1998 Publication in the conference proceedings of EUSIPCO, Rhodes, Greece ...
Guo, Guodong, Yu, Shan, Ma, Songde
openaire +2 more sources