Results 141 to 150 of about 45,269 (354)

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

cGAS deficiency mitigated PM2.5-induced lung injury by inhibiting ferroptosis

Ecotoxicology and Environmental Safety
Ferroptosis emerges as one of the pivotal types of cell death during fine particulate matter (PM2.5)-induced lung injury. The recently discovered cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), triggers the activation of the downstream adaptor ...
Huasong Liu, Juan Wang, Juan Xiong, Zhipeng Hu   +3 more
doaj   +1 more source

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]

, 2019
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju, Dobbs, Nicole, Liou, Jen, Miner, Jonathan J, Sakai, Tomomi, Wu, Jianjun, Yan, Nan   +6 more
core   +1 more source

The Gas Content in Galactic Disks: Correlation with Kinematics

, 2005
We consider the relationship between the total HI mass in late-type galaxies and the kinematic properties of their disks. The mass $M_HI$ for galaxies with a wide variety of properties, from dwarf dIrr galaxies with active star formation to giant low ...
A. A. Smirnova, A. Boselli, A. G. Morozov, A. H. Broeils, A. Shapley, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, B. A. Vorontsov-Velyaminov, B. A. Vorontsov-Velyaminov, B. G. Elmegreen, B. Lewis, C. Martin, D. A. Hunter, D. Bettoni, D. Bizyaev, D. Sprayberry, E. J. Shaya, F. Casoli, F. Combes, F. Combes, F. D. Barazza, G. J. Bendo, I. D. Karachentsev, I. D. Karachentsev, I. D. Karachentsev, I. Karachentsev, J. Hewitt, J. Iglesias-Paramo, L. Cairos, L. Cairos, L. Makarova, L. Zee van, M. A. W. Verheijen, M. C. Martin, M. Kregel, N. Devereux, N. Yasuda, R. A. Swaters, R. B. Tully, R. Becker, R. Grijs de, R. Larson, R. Patterson, S. Boissier, S. Boissier, S. McGaugh, S. Pustilnik, T. Bremnes, T. Kranz, T. Wong, T. X. Thuan, V. L. Polyachenko, W. J. G. Block de, W. Quirk, W.-T. Kim   +60 more
core   +3 more sources

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma

Frontiers in Oncology
PurposeNeoadjuvant chemo-immunotherapy (NACI) has demonstrated significant clinical advantages in head and neck squamous cell carcinomas (HNSCC), while clinical responses vary in different patients.
Miao Wang, Menglin Shi, Yiming Ding, Zishanbai Zhang, Yuze Ge, Zhixin Li, Yixin Jing, Honglian Hu, Xiaohong Chen   +8 more
doaj   +1 more source

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity [PDF]

, 2019
Jiang Dai, Yi-Jiao Huang, Xinhua He, Ming Zhao, Xinzheng Wang, Zhao-Shan Liu, Wen Xue, Hong Cai, Xiaoyan Zhan, Shaoyi Huang, Kun He, Hongxia Wang, Na Wang, Zhihong Sang, Tingting Li, Qiuying Han, Jie Mao, Xinwei Diao, Nan Song, Yuan Chen, Weihua Li, Jianghong Man, Ailing Li, Tao Zhou, Zheng-gang Liu, Xuemin Zhang, Tao Li   +26 more
openalex   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington Disease [PDF]

, 2020
Manish Sharma, Sumitha Rajendrarao, Neelam Shahani, Uri Nimrod Ramĺrez-Jarquĺn, Srinivasa Subramaniam   +4 more
openalex   +1 more source

Chemical Thinning of Peach Fruits with CGA 15281 and CGA 178561

Journal of the American Society for Horticultural Science, 1978
Abstract Beta-chloroethyl-methyl-bis-benzyloxy-silane (CGA 15281) was applied to 6 Eastern U.S. grown peach ( Prunus persica (L.) Batsch) cultivars. Thinning response varied considerably with cultivar, timing, concentration and year.
openaire   +1 more source