National survey of Escherichia coli causing extraintestinal infections reveals the spread of drug-resistant clonal groups O25b:H4-B2-ST131, O15:H1-D-ST393 and CGA-D-ST69 with high virulence gene content in Spain [PDF]
Jorge Blanco+19 more
openalex +1 more source
X‐ray controlled release strategy in cancer therapy
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan+5 more
wiley +1 more source
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan+12 more
wiley +1 more source
Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade [PDF]
Eric Lam+2 more
openalex +1 more source
Combating cancer immunotherapy resistance: a nano‐medicine perspective
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong+10 more
wiley +1 more source
Preservation of
Magdalena Piskorska+6 more
openalex +1 more source
Effects of the Dietary Supplement 5α‐Hydroxy‐Laxogenin in the Orchiectomized Rat Model
The dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated in the castrated male rat for potential androgenic and anabolic effects. Moreover, androgen receptor binding of 5α‐hydroxy‐laxogenin was modelled by in silico docking. While molecular modelling supports androgen receptor binding, we observed neither androgenic nor anabolic effects ...
Daniel Derwand+4 more
wiley +1 more source
Three‐Dimensional Graphene Aerogel Materials for Supercapacitors: Strategies and Mechanisms
An overview of this review about synthesis and drying of GAs, modified aerogel materials and applications in various types of supercapacitors. Graphene aerogels (GAs) exhibit exceptional potential in energy storage, particularly for high‐capacity supercapacitors (SCs), owing to their unique three‐dimensional (3D) porous structure, high conductivity ...
Xiaobin Gong+4 more
wiley +1 more source
HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
Summary: The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity.
Lei Chu+11 more
doaj
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang+7 more
wiley +1 more source