Results 151 to 160 of about 24,434 (294)

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment. [PDF]

Mol Cancer
Wang Q, Yu Y, Zhuang J, Liu R, Sun C.
europepmc   +1 more source

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein [PDF]

, 2015
Jianjun Wu, Wenwei Li, Yaming Shao, Denis Avey, Bishi Fu, Joseph Gillen, Travis H. Hand, Siming Ma, Xia Liu, Wendell Miley, Andreas Konrad, Frank Neipel, Michael Stürzl, Denise Whitby, Hong Li, Fanxiu Zhu   +15 more
openalex   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Cyclic GMP-AMP Synthase (cGAS) Deletion Promotes Less Prominent Inflammatory Macrophages and Sepsis Severity in Catheter-Induced Infection and LPS Injection Models. [PDF]

Int J Mol Sci
Suksamai C, Kaewduangduen W, Phuengmaung P, Sae-Khow K, Charoensappakit A, Udomkarnjananun S, Lotinun S, Kueanjinda P, Leelahavanichkul A.   +8 more
europepmc   +1 more source

Alleviating Effects of Citrus Polymethoxyflavones on Autoimmune Thyroiditis via IL‐17 Signaling Pathway

Food Frontiers, EarlyView.
Citrus flavonoid extracts reduced TPO‐ Ab levels in AITDs cell models. PMFs exhibited the strongest effect on alleviating AITDs among citrus flavonoids. Tangeretin modulated IL‐ 17 signaling pathway to prevent AITDs, and reduced NaI‐ induced thyroid damage in AITDs mouse model.
Manxi Wu, Han Yang, Yuhao Wu, Yuanxiao Yin, Junhao Li, Yongfu Ge, Cui Sun, Jinping Cao, Dengliang Wang, Yixiong Zheng, Yue Wang, Chongde Sun   +11 more
wiley   +1 more source

Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants

Global Challenges, EarlyView.
This review has systematically evaluated the oxidative damage of cornea, tear film, lacrimal gland, conjunctiva and meibomian gland for dry eye, and concluded the antioxidants that are either commercially available or in the research phase. GQDs: Graphene quantum dots; LF: lactoferrin; ROS: Reactive oxygen species; SOD: Superoxide dismutase; tFNA ...
Rong Hu, Jian Shi, Can‐Ming Xie, Xiao‐Lei Yao   +3 more
wiley   +1 more source

Revisiting In-Gas Transformations of Quinate Conjugates Through the LC-qTOF-MS and Molecular Networking Topology. [PDF]

Rapid Commun Mass Spectrom
Moyo NB, Madala NE.
europepmc   +1 more source

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells [PDF]

, 2016
Jolien Vermeíre, Ferdinand Roesch, Daniel Sauter, Réjane Rua, Dominik Hotter, Anouk Van Nuffel, Hanne Vanderstraeten, Evelien Naessens, Veronica Iannucci, Alessia Landi, Wojciech Witkowski, Ann Baeyens, Frank Kirchhoff, Bruno Verhasselt   +13 more
openalex   +1 more source

Accurate and Efficient Detection of Nasopharyngeal Carcinoma Using Multi‐Dimensional Features of Plasma Cell‐Free DNA

Head &Neck, EarlyView.
ABSTRACT Background The incidence of Nasopharyngeal carcinoma (NPC) is rising in recent years, especially in some non‐developed parts of the world. Hence, cost‐efficient means for sensitive detection of NPC are vital. Methods We recruited 646 participants, including healthy individuals, patients with benign nasopharyngeal diseases, and NPC patients for
Song Zhang, Jiahui Tang, Pin Cui, Weihuang He, Xiaohui Lin, Shubing Wang, Yuanxian Liu, Xiaohua Tan, Shu Xu, Mingji Feng, Hanming Lai   +10 more
wiley   +1 more source