Results 151 to 160 of about 34,737 (190)

Low Wage Services: Interpreting the US - German Difference [PDF]

Is the expansion of jobs in low-wage services in Europe restricted by high wages? With services now the main sector source of employment growth this question becomes crucial and we examine it through a detailed comparison of the role of low-wage services
Richard B. Freeman, Ronald Schettkat
core  

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Cell Reports
Summary: The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity.
Lei Chu, Li Qian, Yu Chen, Shengnan Duan, Ming Ding, Wu Sun, Wei Meng, Juanjuan Zhu, Quanyi Wang, Haiping Hao, Chen Wang, Shufang Cui   +11 more
doaj  

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

Nature, 2022
H. Sladitschek-Martens, AL Guarnieri, Giulia Brumana, Francesca Zanconato, G. Battilana, Romy Lucon Xiccato, T. Panciera, M. Forcato, S. Bicciato, V. Guzzardo, M. Fassan, Lorenzo Ulliana, A. Gandin, C. Tripodo, M. Foiani, G. Brusatin, M. Cordenonsi, S. Piccolo   +17 more
semanticscholar   +1 more source

Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy

Molecular Therapy: Nucleic Acids
Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon (IFN-I) responses. Yet, current approaches to cGAS-STING activation rely on STING agonists, which
Shurong Zhou, Ting Su, Furong Cheng, Janet Cole, Xiang Liu, Bei Zhang, Shaheer Alam, Jinze Liu, Guizhi Zhu   +8 more
doaj  

cGAS deficiency mitigated PM2.5-induced lung injury by inhibiting ferroptosis

Ecotoxicology and Environmental Safety
Ferroptosis emerges as one of the pivotal types of cell death during fine particulate matter (PM2.5)-induced lung injury. The recently discovered cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), triggers the activation of the downstream adaptor ...
Huasong Liu, Juan Wang, Juan Xiong, Zhipeng Hu   +3 more
doaj  

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Cell, 2020
Chien-Hsiung Yu, Sophia Davidson, C. Harapas, J. B. Hilton, Michael J. Mlodzianoski, P. Laohamonthonkul, Cynthia Louis, R. R. J. Low, Jonas Moecking, D. De Nardo, Katherine R Balka, D. Calleja, F. Moghaddas, Erya Ni, C. Mclean, A. Samson, S. Tyebji, C. Tonkin, C. Bye, B. J. Turner, Geneviève Pépin, M. Gantier, K. Rogers, K. McArthur, P. Crouch, S. Masters   +25 more
semanticscholar   +1 more source

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling [PDF]

, 2018
Miner, Cathrine A., Miner, Jonathan J., Qian, Wei   +2 more
core   +1 more source

STING-associated vasculopathy develops independently of IRF3 in mice [PDF]

, 2017
Ai, Teresa L, Bennion, Brock G, Gonugunta, Vijay K, Irizarry-Caro, Ricardo A, Miner, Cathrine A, Miner, Jonathan J, Platt, Derek J, Sakai, Tomomi, Smith, Amber M, Warner, James D, Wu, Jianjun, Yan, Nan   +11 more
core   +1 more source

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The cGAS-STING pathway and cancer.

Nature Cancer, 2022
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumorigenesis, from malignant cell transformation to metastasis.
Natasha Samson, A. Ablasser
semanticscholar   +3 more sources

Interplay of cGAS with chromatin

Trends in Biochemical Sciences, 2021
Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninfectious settings of cellular stress and injury. The indiscriminate ability of double-stranded DNA (
Wischnewski, Marilena, Ablasser, Andrea
openaire   +3 more sources