Results 161 to 170 of about 45,269 (354)
EMBO reports, 2017 Recognition of foreign nucleic acids by the immune system is essential to host protection against many viral and bacterial infections. It relies on the capacity of innate immune sensors to selectively distinguish self‐ and non‐self‐nucleic acids, on the basis of a variety of parameters including base modifications, sequence composition, length or ...
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Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
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Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis [PDF]
Wei Xie +5 more
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Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia [PDF]
, 2022 İsmail Yılmaz +11 more
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Advanced Science, EarlyView.Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang +13 more
wiley +1 more source
Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon
mBioNuclear cyclic GMP-AMP synthetase (cGAS) binds to nucleosome with high affinity to prevent its activation by self-DNA. Upon stimulation with double-stranded DNA, cGAS is activated and translocates from the nucleus to the cytoplasm, guided by its N ...
Lei Wu +8 more
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The role of cGAS-STING pathway in the development of radiation-induced lung injury [PDF]
Xinyao Zhao +6 more
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