Results 161 to 170 of about 24,434 (294)

The cGAS/STING Pathway: Friend or Foe in Regulating Cardiomyopathy. [PDF]

Cells
Wang W, Gao Y, Lee HK, Yu AC, Kipp M, Kaddatz H, Zhan J.   +6 more
europepmc   +1 more source

Correction to “Inhibition of CDH11 Activates cGAS‐STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma”

Advanced Science, EarlyView.
wiley   +1 more source

Multidimensional Prognostic Index as a Predictor of Mortality in Head and Neck Cancer Patients: A Cohort Study

Head &Neck, EarlyView.
ABSTRACT Background Head and neck cancer (HNC) significantly impacts older adults, with mortality influenced by multiple factors. The Multidimensional Prognostic Index (MPI), derived from comprehensive geriatric assessment (CGA), may improve risk stratification and clinical decision making. Methods An observational cohort study was conducted at Erasmus
Ajay T. Bakas, Aniel Sewnaik, Femke Flikweert, Robert Jan Baatenburg de Jong, Francesco Mattace‐Raso, Harmke Polinder‐Bos   +5 more
wiley   +1 more source

A Methodology for the Hybridization Based in Active Components: The Case of cGA and Scatter Search [PDF]

, 2016
Andrea Villagra, Enrique Alba, Guillermo Leguizamón   +2 more
openalex   +1 more source

Generation and functional analysis of melanoma antigen‐specific CD8+ T cells derived from S/MAR vector‐transfected human induced pluripotent stem cells

International Journal of Cancer, EarlyView.
What's New? Adoptive cell therapy (ACT) with tumor antigen‐specific CD8+ T cells has shown success in clinical trials treating patients with advanced or metastatic melanoma. Here, the authors established protocols for generating CD8+ T cells from human induced pluripotent stem cells (hiPSCs) expressing a melanoma‐specific T cell receptor (TCR) or ...
Juliane Poelchen, Sandra Pardo, Daniel Novak, Qian Sun, Tamara Steinfass, Marlene Vierthaler, Özge Cicek Sener, Karol Granados Blanco, Yiman Wang, Jan Peter Nicolay, Pierre Guermonprez, Richard Harbottle, Viktor Umansky, Jochen Utikal   +13 more
wiley   +1 more source

Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy

Molecular Therapy: Nucleic Acids
Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon (IFN-I) responses. Yet, current approaches to cGAS-STING activation rely on STING agonists, which
Shurong Zhou, Ting Su, Furong Cheng, Janet Cole, Xiang Liu, Bei Zhang, Shaheer Alam, Jinze Liu, Guizhi Zhu   +8 more
doaj  

Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy. [PDF]

Mol Cancer
Zeng Q, Liu M, Wang Z, Zhou R, Ai K.
europepmc   +1 more source

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1 [PDF]

, 2016
Jonathan Maelfait, Anne Bridgeman, Adel Benlahrech, Chiara Cursi, Jan Rehwinkel   +4 more
openalex   +1 more source

Serological Indicators and Survival Analysis of Synaptophysin‐Positive Gastric Cancer Patients: A Retrospective Study

iLABMED, EarlyView.
SYN expression in patients with gastric cancer is correlated with the degree of differentiation and Lauren's typing. The prognosis of SYN‐positive gastric cancer patients is worse than that of SYN‐negative patients. ABSTRACT Background This study aims to determine prognostic indicators of synaptophysin (SYN) positive gastric cancer with neuroendocrine ...
Xuemei Wei, Xu Zhang, Jiaqi Zhang, Lin Zhu, Guanghong Guo   +4 more
wiley   +1 more source

cGAS deficiency mitigated PM2.5-induced lung injury by inhibiting ferroptosis

Ecotoxicology and Environmental Safety
Ferroptosis emerges as one of the pivotal types of cell death during fine particulate matter (PM2.5)-induced lung injury. The recently discovered cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), triggers the activation of the downstream adaptor ...
Huasong Liu, Juan Wang, Juan Xiong, Zhipeng Hu   +3 more
doaj