Results 171 to 180 of about 34,737 (190)
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Science, 2021
Innate Immunity Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al.
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Innate Immunity Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al.
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Nature Reviews Molecular Cell Biology, 2018
Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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2007
Recent advances in genome sequencing technology and algorithms have made it possible to determine the sequence of a whole genome quickly in a cost-effective manner. As a result, there are more than 200 completely sequenced genomes. However, annotation of a genome is still a challenging task.
Kwangmin Choi, Sun Kim, Youngik Yang
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Recent advances in genome sequencing technology and algorithms have made it possible to determine the sequence of a whole genome quickly in a cost-effective manner. As a result, there are more than 200 completely sequenced genomes. However, annotation of a genome is still a challenging task.
Kwangmin Choi, Sun Kim, Youngik Yang
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Modified cGA for electromagnetic optimization
2014 XXXIth URSI General Assembly and Scientific Symposium (URSI GASS), 2014Compact Genetic Algorithm (cGA), which uses a probability vector (PV) to represent the population, has been proposed as an alternative of the simple Genetic algorithm (sGA), which greatly reduces the memory storage requiring during its performance. The cGA, however, just performed equivalently to sGA.
Van Ha, Bui +4 more
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Science Signaling
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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Science-Business eXchange, 2013
University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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cGAS Conducts Micronuclei DNA Surveillance
Trends in Cell Biology, 2017DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Carina C. de Oliveira Mann +1 more
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Molecular mechanisms and cellular functions of cGAS–STING signalling
Nature reviews. Molecular cell biology, 2020K. Hopfner, V. Hornung
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Clinical Chemical Laboratory Medicine, 2007
Chromogranin A (CgA) is an acidic glycoprotein produced by many neuroendocrine cells and neurons. Currently, two different methods for assaying CgA, immunoradiometric assay (IRMA) and enzyme-linked immunosorbent assay (ELISA), are widely used in routine practice.
Ettore Marubini +6 more
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Chromogranin A (CgA) is an acidic glycoprotein produced by many neuroendocrine cells and neurons. Currently, two different methods for assaying CgA, immunoradiometric assay (IRMA) and enzyme-linked immunosorbent assay (ELISA), are widely used in routine practice.
Ettore Marubini +6 more
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cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Nature, 2022Christy Hong +16 more
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