T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Collaborative Group of the Americas on Inherited Gastrointestinal Cancers (CGA-IGC) Annual Virtual Meeting, November 13–15, 2021 [PDF]
, 2022 Matthew Yurgelun +99 more
openalex +1 more source
Nucleic acid sensors and programmed cell death [PDF]
, 2020 Liverpool, Layal +2 more
core +2 more sources
Advanced Intelligent Discovery, EarlyView.Deep learning‐based denoising models are applied to DNA data storage systems to enhance error reduction and data fidelity. By integrating DnCNN with DNA sequence encoding methods, the study demonstrates significant improvements in image quality and correction of substitution errors, revealing a promising path toward robust and efficient DNA‐based ...
Seongjun Seo +5 more
wiley +1 more source
Origin and evolution of planetary atmospheres [PDF]
This report concerns several research tasks related to the origin and evolution of planetary atmospheres and the large-scale distribution of volatile elements in the Solar System. These tasks and their present status are as follows: (1) we have conducted
Lewis, John S.
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Marden–Walker syndrome (MWS; OMIM 248700) is an extremely rare congenital disorder characterized by multiple joint contractures, craniofacial dysmorphism, neurological abnormalities, and multisystem involvement. Although historically diagnosed on clinical grounds, only a few cases have been molecularly confirmed.
Guilherme Sotto Battiston +35 more
wiley +1 more source
MLKL Deficiency Attenuated Hepatocyte Oxidative DNA Damage by Activating Mitophagy to Suppress Macrophage cGAS-STING Signaling During Liver Ischemia and Reperfusion Injury. [PDF]
, 2022 Zhuqing Rao +9 more
openalex +1 more source
Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease
Animal Models and Experimental Medicine, EarlyView.Alzheimer's disease (AD) is the most common neurodegenerative disorder, and mitochondrial dysfunction has been confirmed in AD patients and mouse models. However, the pathogenic genes associated with AD and early diagnostic methods based on mitochondrial function remain to be explored.
Xuchao Zhu, Ling Zhang, Chuan Qin
wiley +1 more source
Spreading depolarization activates the cGAS-STING pathway and drives cranial nociception: therapeutic potential of STING modulation. [PDF]
J Headache PainSoylu KO +7 more
europepmc +1 more source