Results 181 to 190 of about 34,737 (190)

Cellular functions of cGAS-STING signaling.

Trends in Cell Biology, 2022
Chen Chen, Pinglong Xu
semanticscholar   +1 more source

The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence

Cell Death and Differentiation, 2023
Sisi Jiang, Tian Tian, Hang Yao, Xiaohui Xia, Cong Wang, Lei Cao, Gang Hu, Ren-Hong Du, Ming Lu   +8 more
semanticscholar   +1 more source

Liquid droplets step on the cGAS

Science, 2018
Immunology Spontaneous partitioning of a homogeneous solution of molecules, or liquid-phase separation, underlies the formation of cellular bodies from P granules to nucleoli. Essentially, dense-phase liquid droplets act like cellular compartments. Du and Chen show that DNA binding to its cytoplasmic sensor, cyclic GMP–AMP synthase (cGAS), results in ...
openaire   +2 more sources

AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases.

Nature
Heyu Li, Chao Liu, Ran Li, Lili Zhou, Yu Ran, Qiqing Yang, Huizhe Huang, Huasong Lu, Hai Song, Bing Yang, Heng Ru, Shixian Lin, Long Zhang   +12 more
semanticscholar   +1 more source

Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

Molecular Cell
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
openaire   +2 more sources

A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis

Nature Cell Biology, 2022
Dan Zhang, Yutong Liu, Yezhang Zhu, Qian Zhang, Hongxin Guan, Shengduo Liu, Shasha Chen, Chen Mei, Chen Chen, Zhiyong Liao, Y. Xi, S. Ouyang, Xin-Hua Feng, T. Liang, Li Shen, Pinglong Xu   +15 more
semanticscholar   +1 more source

Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice

bioRxiv, 2022
Xiaochun Xie, Guanqin Ma, Xiaohong Li, Jie-Bin Zhao, Z. Zhao, Jianxiong Zeng   +5 more
semanticscholar   +1 more source

cGAS senses translation stress

Nature Cell Biology, 2021
openaire   +3 more sources

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Nature Immunology, 2016
Qi Chen, Lijun Sun, Zhijian J. Chen
semanticscholar   +1 more source

DNA sensing by the cGAS–STING pathway in health and disease

Nature reviews genetics, 2019
M. Motwani, Scott Pesiridis, K. Fitzgerald   +2 more
semanticscholar   +1 more source