Results 261 to 270 of about 24,434 (294)

Unintegrated HIV-1 DNA recruits cGAS via its histone-binding domain to escape innate immunity. [PDF]

Proc Natl Acad Sci U S A
Jahan C, Bonnet-Madin L, Machida S, Sobhian B, Thenin-Houssier S, Benkirane M.   +5 more
europepmc   +1 more source

PC4 Potentially Predicts Chemoradiation‐Induced Antitumor Immunity in Esophageal Squamous Cell Carcinoma

Cancer Science, EarlyView.
In present study, we describe the tumor‐infiltrating CD8+T cells pattern induced by neoadjuvant chamoradiation (CRT) in human esophageal squamous cell carcinoma (ESCC), and reveal that PC4 expression predicted CRT‐induced antitumor immune response with high probability and may help stratify subgroups with better prognosis in patients with locally ...
Jieyong Tian, Xiaoying Wei, Huiquan Liu, Qingsong Pang, Dong Qian, Haiming Dai   +5 more
wiley   +1 more source

Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP. [PDF]

J Biol Chem
Zhang X, Zhuang M, Zhang H, Zhu Y, Yang J, Wu X, Yu X, Tao J, Liu X.   +8 more
europepmc   +1 more source

Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Obesity promotes the progression of intervertebral disc degeneration (IVDD) through the mTORC1/FABP4 axis. Targeting FABP4 effectively ameliorates nucleus pulposus dysfunction and angiogenesis in obesity‐related IVDD. ABSTRACT Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic ...
Lin Han, Fudong Li, Huiqiao Wu, Weiheng Wang, Peiwen Chen, Weicheng Xia, Yang Liu, Kaiqiang Sun, Wenbo Lin   +8 more
wiley   +1 more source

Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance. [PDF]

Exp Mol Med
Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, Wu T, Xu L, Guo W, Gu Y.   +9 more
europepmc   +1 more source

Epithelial <i>Atg5</i> Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During <i>Pseudomonas</i> Infection. [PDF]

MedComm (2020)
Wang J, Zhang L, Liu Y, Liu Y, Xiong A, Ran Q, He X, Wong VKW, Combs C, Li G, Wu M.   +10 more
europepmc   +1 more source

Understanding frailty screening of older adults in the emergency department: A survey of emergency physicians in Ontario

Academic Emergency Medicine, EarlyView.
Priyank Bhatnagar, Don Melady, Cameron Thompson, Shelley McLeod, Alice Gray, Keerat Grewal   +5 more
wiley   +1 more source

cGAS and STING in Host Myeloid Cells Are Essential for Effective Cyclophosphamide Treatment of Advanced Breast Cancer. [PDF]

Cancers (Basel)
Lai YG, Liao HT, Chen YH, Huang SW, Liou YH, Wu ZQ, Liao NS.   +6 more
europepmc   +1 more source

cGAS/STING-Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B. [PDF]

FASEB J
Montano MM, Yeh IJ, Ketchart W.
europepmc   +1 more source

The CGAS-STING1 Pathway as a Mediator of Innate Immune Response in Cardiovascular Disease. [PDF]

JACC Asia
Rouhi L, Gurha P, Marian AJ.
europepmc   +1 more source