Results 211 to 220 of about 62,675 (241)

Allosteric Activation of cGMP-Specific, cGMP-Binding Phosphodiesterase (PDE5) by cGMP

Biochemistry, 2002
The effects of cGMP binding on the catalytic activity of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) are unclear because cGMP interacts with both allosteric and catalytic sites specifically. We studied the effects of cGMP on the hydrolysis of a fluorescent substrate analogue, 2'-O-anthraniloyl cGMP, by PDE5 partially purified from rat ...
Daisuke, Okada, Shigeki, Asakawa
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A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation

Nitric Oxide, 2021
Soluble guanylyl cyclase (sGC, also called GC1) is the main receptor for nitric oxide (NO) that catalyzes the production of the second messenger molecule, 3'5' cyclic guanosine monophosphate (cGMP) leading to vasorelaxation, and inhibition of leukocyte recruitment and platelet aggregation.
Adam C. Straub, Annie Beuve
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cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases

1995
Publisher Summary The signaling pathways by which nitric oxide (NO) affects cell function, are by no means limited to the stimulation of guanylate cyclase. Concentrations of NO that activate guanylate cyclase may also have other effects on cells.
T M, Lincoln, P, Komalavilas, N J, Boerth, L A, MacMillan-Crow, T L, Cornwell   +4 more
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Progesterone substitutes: cGMP mediation

Neuroscience & Biobehavioral Reviews, 1986
Over the past 20 years many investigators have shown that one can facilitate sexual receptivity in estrogen-primed rats either by giving progesterone or a drug which stimulates or inhibits a neurotransmitter system. Drugs which have been reported to substitute for progesterone include cholinergic agonists, serotonergic agonists and antagonists ...
R E, Whalen, A H, Lauber
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Insights into cGMP signalling derived from cGMP kinase knockout mice

Frontiers in Bioscience, 2005
cGMP signalling plays an important physiological role in diverse organs including the vasculature, the GI-tract and the nervous system. Furthermore, cGMP-elevating substances such as glyceryl trinitrate are important drugs used in cardiovascular diseases.
Jens, Schlossmann, Robert, Feil, Franz, Hofmann   +2 more
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(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor

European Journal of Pharmacology: Molecular Pharmacology, 1994
In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on the cGMP-dependent protein kinase-mediated protein phosphorylation in intact human platelets was investigated.
E, Butt, M, Eigenthaler, H G, Genieser
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cGMP Pump

Science Signaling, 2000
Cyclic nucleotides are important second messengers. Jedlitschky et al . expressed the human multidrug resistance protein 5 (MDR5) in hamster fibroblasts and showed that these cells exhibit an enhanced high-affinity ATP-dependent transport of cyclic nucleotides into inside-out membrane vesicles.
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Modulation of synaptic function by cGMP and cGMP-gated cation channels

Neurochemistry International, 2004
Cyclic nucleotide-gated cation channels have been studied intensively in the primary sensory neurons of the visual and olfactory systems. Using both anatomical and physiological methods we have shown that they have a much more widespread distribution in the nervous system.
Colin J, Barnstable, Ji-Ye, Wei, Ming-Hu, Han   +2 more
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cGMP in the Vasculature

2009
Cyclic guanosine 3', 5'-monophosphate (cGMP) plays an integral role in the control of vascular function. Generated from guanylate cyclases in response to the endogenous ligands, nitric oxide (NO) and natriuretic peptides (NPs), cGMP influences a number of vascular cell types and regulates vasomotor tone, endothelial permeability, cell growth and ...
Barbara, Kemp-Harper, Harald H H W, Schmidt   +1 more
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