Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]
, 2013 The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman +65 more
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Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP
Pharmaceuticals, 2021 Cyclic guanosine-3′,5′-monophosphate, better known as cyclic-GMP or cGMP, is a classical second messenger involved in a variety of intracellular pathways ultimately controlling different physiological functions.
Ernesto Fedele, Roberta Ricciarelli
doaj +1 more source
Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase ß subunit [PDF]
, 1992 The ß subunit of the cGMP phosphodiesterase (PDE) gene has been identified as the candidate gene for retinal degeneration in the rd mouse. To study the molecular mechanisms underlying degeneration and the potential for gene repair, we have expressed a ...
Applebury, Meredithe L. +5 more
core
Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]
, 2003 Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten +3 more
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A cyclic GMP signalling module that regulates gliding motility in a malaria parasite.
PLoS Pathogens, 2009 The ookinete is a motile stage in the malaria life cycle which forms in the mosquito blood meal from the zygote. Ookinetes use an acto-myosin motor to glide towards and penetrate the midgut wall to establish infection in the vector.
Robert W Moon +8 more
doaj +1 more source
Journal of Neuroscience, 2013 Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca2+ influx in rod and cone photoreceptors. cGMP, the native ligand of the photoreceptor CNG channels, has been associated with cytotoxicity when its levels rise above normal due to defects in
Jianhua Xu +9 more
semanticscholar +1 more source
The Role of cGMP-Dependent Protein Kinase in Controlling Cardiomyocyte cGMP [PDF]
Circulation Research, 2010 See related article, pages 1232–1240 The role of cGMP as a second messenger in physiological and pathophysiological processes is widely appreciated.1,–,3 The successes of drugs that target the cGMP-signaling pathway (nitrovasodilators and PDE5 inhibitors [sildenafil, tadalafil, vardenafil]) have inspired interest in other cardiovascular benefits that ...
openaire +3 more sources
A novel role for cGMP-specific phosphodiesterase, PDE6, in active transport of cGMP [PDF]
BMC Pharmacology, 2005 Efflux of cyclic nucleotides via active transport in many cell types has been documented for many decades. However, the only route of cyclic nucleotide breakdown is via the action of specific phosphodiesterases (PDEs). The mammalian cGMP-specific phosphodiesterase, PDE6, was established as a retinal-specific enzyme.
Miles D. Houslay +2 more
openaire +2 more sources
Chemotaxis von Seeigel-Spermien - kinetische Messungen intrazellulärer Botenstoffe [PDF]
, 2002 The egg-petide resact induces a chemotactical response of sperm from sea urchin Arbacia punctulata. By bindig to a receptor-guanylylcyclase on the flagellar membrane resact activates a signaling-cascade.
Solzin, Johannes
core
Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
Retrovirology, 2007 The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated.
Jeang Kuan-Teh +2 more
doaj +1 more source