Results 31 to 40 of about 50,213 (312)

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

Drug Delivery, 2021
The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the ...
Fang Wang, Yu Deng, Jieting Wang, Luying Yu, Fadian Ding, Wei Lian, Qicai Liu, Xinhua Lin   +7 more
doaj   +1 more source

The therapeutic armamentarium in migraine is quite elderly. [PDF]

, 2014
Global Burden of Disease 2010 study considers migraine as one of the most important noncommunicable diseases in the world, classifying it third in terms of global prevalence (14.70%): it sums up the 54.19% of all the years of life lived with disabilities
Martelletti, Paolo
core   +1 more source

Chronic Migraine: Diagnosis, Characteristics, Lifestyle Modification, Trigger Reduction and Treatment

Journal of Pharmacy and Bioallied Sciences
The most prevalent brain condition that impairs function is migraine. A chronic migraine is a very incapacitating disorder that is defined by having a migraine that lasts for at least 10 days every month.
Roshan Kumar Jha, Ranjit Ambad, Dhruba Hari Chandi, Obaid Noman   +3 more
doaj   +1 more source

Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus [PDF]

, 2018
The superficial dorsal horn (laminae I and II) of the spinal cord contains numerous excitatory and inhibitory interneurons, and recent studies have shown that each of these groups can be divided into several neurochemically distinct populations. Although
Bell, Andrew M., Gutierrez-Mecinas, Maria, Hérau, Marine, Polgár, Erika, Todd, Andrew J.   +4 more
core   +1 more source

Loose Groups of Galaxies in the Las Campanas Redshift Survey [PDF]

, 2000
A ``friends-of-friends'' percolation algorithm has been used to extract a catalogue of dn/n = 80 density enhancements (groups) from the six slices of the Las Campanas Redshift Survey (LCRS). The full catalogue contains 1495 groups and includes 35% of the
Augustus Oemler, Jr., Collins C. A., Dalton G. B., Douglas L. Tucker, Ebeling H., Ebeling H., Holmberg E., Huan Lin, Moore B., Nolthenius R., Olowin R., Paul L. Schechter, Ramella M., Robert P. Kirshner, Sahar S. Allam, Stephen A. Shectman, Stephen D. Landy, Trasarti-Battistoni R., Tucker D. L., Vettolani G., Yasuhiro Hashimoto   +20 more
core   +2 more sources

On Tribo-Test Machine Integrating Pin-on-Disc and Block-on-Ring

Tribology Online, 2007
A concept of integrating more than one tribo-technique, Pin-on-Disc (POD) and Block-on-Ring (BOR), working simultaneously under same test conditions against same counterface is introduced in a new multi-tribo-test-machine. In this machine, different wear
Belal F. Yousif, Nabil. S. M. El-Tayeb
doaj   +1 more source

A Real-World Study of CGRP Monoclonal Antibodies for Migraine: Long-Term Effectiveness and Treatment Adherence. [PDF]

Eur J Neurol
In our 24‐month real‐world study, the mean monthly migraine days (MMDs) significantly decreased from baseline by 6.8, 7.9, 8.7, and 10.0 days at Months 3, 6, 12, and 24, respectively (all p < 0.001). Significant reductions were also observed across all time points in both episodic migraine and chronic migraine subgroups.
Suzuki K, Suzuki S, Kobayashi S, Shioda M, Fujita H, Haruyama Y, Hirata K.   +6 more
europepmc   +2 more sources

Fremanezumab for the Preventive Treatment of Chronic Migraine. [PDF]

, 2017
BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine.
Aycardi, Ernesto, Bigal, Marcelo E., Blankenbiller, Tricia, Dodick, David W., Goadsby, Peter J., Grozinski-Wolff, Melissa, Ma, Yuju, Silberstein, Stephen D., Yang, Ronghua, Yeung, Paul P.   +9 more
core   +2 more sources

Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of DCC Signaling in a Rat Model of Bone Cancer Pain

Journal of Integrative Neuroscience
Background: Bone cancer pain (BCP) is a common primary or metastatic bone cancer complication. Netrin-1 plays an essential role in neurite elongation and pain sensitization.
Zhihao Gong, Yuxin Zhang, Wei Wang, Xin Li, Kai Wang, Xingji You, Jingxiang Wu   +6 more
doaj   +1 more source

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Hongsui Wu, Huanxin Yang, Jian Su, Jian Zhuang, Jianguang Chen, Shiliang Chen, Xiaoning Zhang, Yuhui Zheng, Zhihong Chen   +8 more
core   +1 more source