Results 51 to 60 of about 50,213 (312)

Erenumab is effective in reducing migraine frequency and improving physical functioning [PDF]

, 2018
no abstract ...
Martelletti, Paolo
core   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source

New CGRP Antagonists [PDF]

The Scientific World JOURNAL, 2001
The presentation will focus on BIBN 4096 BS, since this compound is still the only potent calcitonin gene-related peptide (CGRP)-antagonist described so far[1].
H. N. Doods, M. Schindler
openaire   +2 more sources

Functional characteristics of calcitonin gene-related peptide receptors in human Ewing's sarcoma WE-68 cells [PDF]

, 1989
Calcitonin gene-related peptide (CGRP) receptor activity was studied in WE-68 human Ewing's sarcoma cells. 125I-human CGRP bound in a time-dependent, reversible and saturable manner.
Andersen, Bocharov, Brian G. Coon, Calvo, Carmeliet, Chiu, Chiu, Chiu, Cicha, Conway, Cosson, Dai, Davies, Davies, Di Stefano, Diaz-Rohrer, DiMaio, Endres, Eskens, Feaver, Fleming, Frangos, Galvagni, Gavard, Giampietro, Gimbrone, Goel, Gu, Hahn, Hahn, Hahn, Haiko, Harry, Hove, Hwang, Jennifer S. Fang, Jeon-Leon Thomas, Jin, Jinah Han, Jongstra-Bilen, Joukov, Karkkainen, Kubo, Lampugnani, Langille, Liu, Lucitti, Maciag, Madhusudhan Budatha, Manni, Martin A. Schwartz, Mattsson, Moore, Nam, Navarro, Nawroth, Nayak, Nicolas Baeyens, Nigro, Olsson, Orr, Orr, Orr, Osawa, Piedra, Pitulescu, Pohl, Privratsky, Sanguk Yun, Sharpe, Stevens, Tammela, Tedgui, Therien, Tyler D. Ross, Tzima, Vestweber, Wang, Wang, Warfel, Witmer   +80 more
core   +1 more source

Role of Atogepant in the Treatment of Episodic Migraines: Clinical Perspectives and Considerations

Therapeutics and Clinical Risk Management, 2022
Fred Cohen, Hsiangkuo Yuan Jefferson Headache Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, 19107, USACorrespondence: Hsiangkuo Yuan, Jefferson Headache Center, Department of Neurology, Thomas Jefferson University, 900 ...
Cohen F, Yuan H
doaj  

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Is Helicobacter Pylori Associated with a Migraine? [PDF]

, 2017
Objective: To determine whether Helicobacter pylori (H. pylori) is associated with migraine headache. Design: Case-control study. Settings: Local tertiary Hospitals in Cairo, Egypt and in HaferAlbaten, Saudi Arabia.
Ali Radwa A, Mahmoud Mohamed A, Ali Abdelrazak M   +2 more
core   +1 more source

An Investigation into the Prevalence of Migraine and Its Prophylactic Treatment Patterns in the Czech Republic: An Observational Study

Journal of Pain Research, 2020
David Dolezil,1 Jolana Markova,2 Jiri Klimes,3,4 Zuzana Pocikova,3,4 Filip Dostal,3,4 Radka Stepanova,5,6 Adam Svobodnik5,7 1Prague Headache Center, DADO MEDICAL s.r.o., Prague, Czech Republic; 2University Thomayer Hospital, Prague, Czech Republic ...
Dolezil D, Markova J, Klimes J, Pocikova Z, Dostal F, Stepanova R, Svobodnik A   +6 more
doaj  

Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro‐Vascularized Bone Regeneration

Advanced Science, EarlyView.
This study develops neural bioprinted piezoelectric scaffolds which construct local “sensor‐effector” circuit, inspired by the skeletal interoception system. Upon US stimulation sensing and mechanoelectrical coupling by PLLA nanofibers, the incorporated DRG neurons effect through Ca2+ influx‐induced enhanced secretion and expression of CGRP.
Yingze Su, Haomin Wang, Weixi Liu, Kangming Chen, Yiyang Min, Jinbo Zhu, Xueyang Li, Anning Su, Hao Yang, Lei Yang, Yun Ji, Yuxin Zhang, Jisi Zheng, Chi Yang, Chuanglong He, Tao Li, Shuo Chen, Tao Wu, Xiaodong Chen   +18 more
wiley   +1 more source

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

Arthritis &Rheumatology, EarlyView.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source