Results 61 to 70 of about 43,468 (306)

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

An Investigation into the Prevalence of Migraine and Its Prophylactic Treatment Patterns in the Czech Republic: An Observational Study

Journal of Pain Research, 2020
David Dolezil,1 Jolana Markova,2 Jiri Klimes,3,4 Zuzana Pocikova,3,4 Filip Dostal,3,4 Radka Stepanova,5,6 Adam Svobodnik5,7 1Prague Headache Center, DADO MEDICAL s.r.o., Prague, Czech Republic; 2University Thomayer Hospital, Prague, Czech Republic ...
Dolezil D, Markova J, Klimes J, Pocikova Z, Dostal F, Stepanova R, Svobodnik A   +6 more
doaj  

New CGRP Antagonists [PDF]

The Scientific World JOURNAL, 2001
The presentation will focus on BIBN 4096 BS, since this compound is still the only potent calcitonin gene-related peptide (CGRP)-antagonist described so far[1].
H. N. Doods, M. Schindler
openaire   +2 more sources

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission

Frontiers in Immunology, 2021
BackgroundThe vasodilator neuropeptide calcitonin gene-related peptide (CGRP) plays both detrimental and protective roles in different pathologies. CGRP is also an essential component of the neuro-immune dialogue between nociceptors and mucosal immune ...
Jammy Mariotton, Anette Sams, Emmanuel Cohen, Alexis Sennepin, Gabriel Siracusano, Francesca Sanvito, Lars Edvinsson, Nicolas Barry Delongchamps, Marc Zerbib, Lucia Lopalco, Morgane Bomsel, Yonatan Ganor   +11 more
doaj   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Safety and efficacy of fremanezumab in real clinical practice in patients with chronic migraine

Неврология, нейропсихиатрия, психосоматика
Objective: to evaluate the efficacy and safety of fremanezumab in patients with chronic migraine (CM) in real-life clinical practice.Material and methods. In a 12-week, open-label, prospective study, 27 patients (21 women and 6 men, mean age 41±10 years)
G. N. Belskaya, A. V. Krasnikov, E. A. Kiryanova, M. E. Prokopovich, E. V. Sakharova, G. V. Makarov   +5 more
doaj   +1 more source

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Nature, 2018
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type ...
Yi-Lynn Liang, M. Khoshouei, Giuseppe Deganutti, A. Glukhova, Cassandra Koole, T. Peat, M. Radjainia, J. Plitzko, W. Baumeister, L. Miller, D. Hay, A. Christopoulos, C. Reynolds, D. Wootten, P. Sexton   +14 more
semanticscholar   +1 more source

Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

Journal of Molecular Neuroscience, 2020
The calcitonin gene-related peptide (CGRP) family of neuropeptides, consists of CGRP, adrenomedullin, amylin, and calcitonin. The receptors consist of either calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) which for function needs an
L. Edvinsson, A. Grell, K. Warfvinge
semanticscholar   +1 more source