Results 1 to 10 of about 3,615 (181)

Dormant Metastases Exhibit a Unique Phenotype Primarily Promoted by the Ch25h Gene and Are Maintained in Dormancy by T Lymphocytes [PDF]

MedComm
During the course of cancer, metastatic cells frequently enter a state of dormancy that can be controlled by the immune system. In our laboratory, we developed a preclinical mouse model of metastatic immunodormancy.
Virginia Chamorro, Ignacio Algarra, Verónica Sanz, María Pulido, Irene Romero, Estefanía Chico, Marina Millán, María Escaño‐Maestre, Pablo Botella, Isabel Linares, Ángel M. García‐Lora   +10 more
doaj   +5 more sources

Cholesterol 25‐Hydroxylase Enhances Myeloid‐Derived Suppressor Cell (MDSC) Immunosuppression via the Stimulator of Interferon Genes (STING)‐Tank‐Binding Kinase 1 (TBK1)‐Receptor‐Interacting Protein Kinase 3 (RIPK3) Pathway in Colorectal Cancer [PDF]

MedComm
Myeloid‐derived suppressor cells (MDSCs) represent a significant immunosuppressive population within the tumor microenvironment of colorectal cancer (CRC).
Dongqin Zhou, Yu Chen, Xudong Liu, Juan He, Luyao Shen, Yongpeng He, Jiangang Zhang, Yu Zhou, Nan Zhang, Yanquan Xu, Juan Lei, Ran Ren, Huakan Zhao, Xianghua Zeng, Yongsheng Li   +14 more
doaj   +3 more sources

CH25H Promotes Autophagy and Regulates the Malignant Progression of Laryngeal Squamous Cell Carcinoma Through the PI3K‐AKT Pathway [PDF]

Cancer Medicine
Background Laryngeal squamous cell carcinoma (LSCC) is a type of cancer of the respiratory tract that often presents with subtle symptoms at the early stage and is susceptible to recurrence and metastasis. Materials and Methods To find out key regulatory
Zhenfei Xiang, Senquan Yu, Yuxin Xu, Huacai Xiong, Danfei Hu, Qun Li, Zhenhua Wu   +6 more
doaj   +4 more sources

Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation

Acta Biochimica et Biophysica Sinica, 2022
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase
Wang Yaqiong, Zhang Jin, Chen Jie, Wang Dan, Yu Yang, Qiu Pei, Wang Qiqi, Zhao Wenbao, Li Zhao, Lei Ting   +9 more
doaj   +4 more sources

Leukocyte CH25H is a potential diagnostic and prognostic marker for lung adenocarcinoma

Scientific Reports, 2022
Metastasis, a major challenge during the treatment of lung cancer, causes deterioration in patient health outcomes. Thus, to address this problem, this study aimed to explore the role and contribution of Cholesterol 25-Hydroxylase (CH25H) as a potential ...
Jun Zhang, Lidong Xu, Jun Gao, Jieyi Li, Xiaokai Zhao, Pengmin Yang, Yujun Ge, Dawei Guo, Zhonghua Liu, Xiyong Wang, Wenchao Gu, Pengli Wang, Xun Hu, Ziying Gong, Daoyun Zhang   +14 more
doaj   +3 more sources

Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy

Frontiers in Immunology, 2023
Autophagy plays an important role in host antiviral defense. The avian leukosis virus subgroup J (ALV-J) has been shown to inhibit autophagy while promoting viral replication. The underlying autophagic mechanisms, however, are unknown.
Tingting Xie, Tingting Xie, Tingting Xie, Min Feng, Xi Zhang, Xi Zhang, Xi Zhang, Xiaoqi Li, Xiaoqi Li, Xiaoqi Li, Guodong Mo, Guodong Mo, Guodong Mo, Meiqing Shi, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang   +16 more
doaj   +3 more sources

Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke

Journal of Neuroinflammation, 2023
Background Microglial polarization is one of the most promising therapeutic targets for multiple central nervous system (CNS) disorders, including ischemic stroke.
Yueman Zhang, Yunlu Guo, Ruqi Li, Tingting Huang, Yan Li, Wanqin Xie, Chen Chen, Weijie Chen, Jieqing Wan, Weifeng Yu, Peiying Li   +10 more
doaj   +3 more sources

Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase [PDF]

Journal of Virology
Cholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outperforms IFN-α ...
Le Wang, Hongxiao Song, Fengchao Xu, Yujia Zhu, Mian Huang, Jing Xu, Xiaolu Li, Fei Wang, Fan Yang, Yang Lei, Pujun Gao, Guangyun Tan   +11 more
doaj   +2 more sources

MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats [PDF]

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder.
Xiaochen Li, Xiaochen Li, Li Zhang, Li Zhang, Xiaoqing Shi, Xiaoqing Shi, Taiyang Liao, Taiyang Liao, Nongshan Zhang, Nongshan Zhang, Yifan Gao, Runlin Xing, Runlin Xing, Peimin Wang, Peimin Wang   +14 more
doaj   +3 more sources

Silencing of Cholesterol 25-Hydroxylase Attenuates Lipopolysaccharide-Induced Cardiomyocyte Damage In Vitro. [PDF]

J Cell Mol Med
ABSTRACT The underlying mechanisms of sepsis‐induced myocardial dysfunction (SIMD) remain elusive, and no targeted therapies currently exist. This study aimed to explore the expression features and functional effects of cholesterol 25‐hydroxylase (CH25H) in SIMD in vitro.
Men YJ, Cheng HB, Dong YL, Gong Y, An YQ, Jin YL, Hao SN, Ma Y, Tian YP.   +8 more
europepmc   +2 more sources