Molecular Metabolism, 2020 Objective: Expansion of visceral adipose tissue (VAT) and metabolic inflammation are consequences of obesity and associated with type 2 diabetes (T2DM).
Lucia Russo +7 more
doaj +3 more sources
Cells, 2023 Alveolar macrophages (AM) are long-lived tissue-resident innate immune cells of the airways. AM are key effectors of recognition, initiation, and resolution of the host defense against microbes and play an essential role in mediating host responses to ...
Soo Jung Cho +4 more
doaj +3 more sources
Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein [PDF]
Journal of VirologyNewcastle disease virus (NDV) is a significant enveloped virus within the Paramyxoviridae family, posing a major threat to the global poultry industry.
Guangmei Zhu +15 more
doaj +2 more sources
Detection of CH25H gene polymorphism associated with growth traits of Yuexi frizzled chicken [PDF]
Poultry ScienceYuexi frizzled chicken has unique disease resistance and growth performance. Cholesterol 25-hydroxylase (CH25H) and its enzymatic product 25-hydroxycholesterol (25-HC) are recognized as key modulators of inflammatory signaling, immune defense, and viral ...
Yuying Li +6 more
doaj +2 more sources
Pan-cancer multi-dimensional characterization and biological significance of cholesterol 25-hydroxylase (CH25H) [PDF]
Discover OncologyBackground CH25H encodes an interferon-inducible hydroxylase that converts cholesterol to 25-hydroxycholesterol (25-HC), linking lipid homeostasis to immune regulation. Its pan-cancer relevance remains incompletely defined.
Zhongqi Diao, Yi Chen, Wenjia Guo
doaj +2 more sources
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis [PDF]
Journal of Crohn's and Colitis, 2019 Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need.
Alvarado, M. N. Gonzalez +16 more
core +8 more sources
Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1. [PDF]
Inflamm ResAbstract Objective Mitogen-activated protein kinase phosphatase-1 (MKP-1) is an anti-inflammatory enzyme whose expression is increased by glucocorticoids (GCs). MKP-1 dephosphorylates and thereby inactivates mitogen-activated protein kinases (MAP kinases) which are major signaling pathways ...
Lehtola T +7 more
europepmc +2 more sources
Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae [PDF]
Frontiers in AgingIntroductionAlveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to Streptococcus pneumoniae. Changes in lipid metabolism in AM can alter cellular function and biology.
David G. Thomas +5 more
doaj +2 more sources
Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities [PDF]
Viruses, 2020 With the frequent outbreaks of emerging infectious diseases in recent years, an effective broad-spectrum antiviral drug is becoming an urgent need for global public health.
Jin Zhao +4 more
doaj +3 more sources
Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs
BMC Veterinary Research, 2022 Background Zedoary turmeric oil extracted from the roots of curcuma (Curcuma aeruginosa Roxb.) is used for the treatment of myocarditis in China. EMCV infection causes abortion in pregnant sows and myocarditis in piglets.
Jiangang Zheng +9 more
doaj +3 more sources