Results 21 to 30 of about 3,615 (181)

CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD

Immunobiology
Objective: Chronic obstructive pulmonary disease (COPD) is intricately linked to pulmonary fibrosis, yet the underlying mechanisms remain unclear. This study investigates whether CH25H/25-hydroxycholesterol (25-HC) promotes pulmonary fibrosis in COPD by ...
Ying Li, Guangzhi Xiao, Xianghui Fu, Xing Luo, Fengfan Yang, Yadan Li, Zhaohui Zheng   +6 more
doaj   +3 more sources

Single-cell sequencing reveals the role of <i>IL-33</i> ⁺ endothelial subsets in promoting early gastric cancer progression. [PDF]

Imeta
A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...
Zhou L, Yang M, Deng C, Hu M, Wu S, Lai K, Zhang L, Chen Z, Tang Q, Wang Q, Chen L, Zha R, Chen Y, Tan Y, He S, Zhou Z.   +15 more
europepmc   +2 more sources

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses. [PDF]

Transbound Emerg Dis
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Zhang J, Liu Y, Ren S, Wang Z, Li Y, Peng L, Fang R.   +6 more
europepmc   +2 more sources

Krüppel-Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment. [PDF]

Cancer Med
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Tang M, Tian B, Zhou J, Ma D, Sun R, Li Q.   +5 more
europepmc   +2 more sources

Involvement of CCL2 and CH25H Genes and TNF signaling pathways in mast cell activation and pathogenesis of chronic spontaneous urticaria

Frontiers in Immunology, 2023
Chronic spontaneous urticaria (CSU), a mast cell-driven disease, substantially affects the quality of life. While genetics affect CSU susceptibility and severity, the specific genetic factors associated with mast cell activation in CSU remain elusive. We
Xiaobin Fang, Yueyi Weng, Xiaochun Zheng, Xiaochun Zheng, Xiaochun Zheng   +4 more
doaj   +3 more sources

25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation [PDF]

Journal of Neuroinflammation
Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and, in response to different inflammatory stimuli, overexpress a proinflammatory signature of genes.
Johnathan Romero, Danira Toral-Rios, Jinsheng Yu, Steven M. Paul, Anil G. Cashikar   +4 more
doaj   +2 more sources

Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma [PDF]

Nature Communications
In melanoma, lymphangiogenesis correlates with metastasis and poor prognosis and promotes immunosuppression. However, it also potentiates immunotherapy by supporting immune cell trafficking.
Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues   +22 more
doaj   +2 more sources

Oxysterols contribute to immune cell recruitment in SLE skin lesions [PDF]

Arthritis Research & Therapy
Background Abnormal oxysterol metabolism has been observed in the peripheral blood of SLE patients, but its role in systemic lupus erythematosus (SLE) skin lesions remains unclear.
Xiaoyun Chen, Lianlian Ouyang, Sujie Jia, Ming Zhao   +3 more
doaj   +2 more sources

25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer’s disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition [PDF]

Journal of Neuroinflammation
This study investigates the role of 25-hydroxycholesterol (25HC), a metabolite produced by cholesterol hydroxylase encoded by the Ch25h gene, in modulating microglial function and its potential implications in Alzheimer’s disease (AD) pathology.
Hayoung Choi, Haeng Jun Kim, Sang-Eun Lee, Hyun Ho Song, Jieun Kim, Jihui Han, June-Hyun Jeong, Do Yup Lee, Sunghoe Chang, Inhee Mook-Jung   +9 more
doaj   +2 more sources

Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced SteatosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities.
Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li, Liang Bai, Zuyi Yuan, John Y-J. Shyy   +10 more
doaj   +1 more source