Aging, 2023 Lipid metabolism plays an essential role in the genesis and progress of acute myocardial infarction (AMI). Herein, we identified and verified latent lipid-related genes involved in AMI by bioinformatic analysis. Lipid-related differentially expressed genes (DEGs) involved in AMI were identified using the GSE66360 dataset from the Gene Expression ...
Liu, Zheng-Yu +6 more
openaire +2 more sources
Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]
, 2004 Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S. +7 more
core +5 more sources
Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination
Frontiers in Immunology, 2021 Cholesterol is essential for building and maintaining cell membranes and is critical for several steps in the replication cycle of viruses, especially for enveloped viruses. In mammalian cells virus infections lead to the accumulation of the oxysterol 25-
Mikolaj Adamek +19 more
doaj +1 more source
TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum [PDF]
, 2019 OBJECTIVE Describe the implementation and effects of Mobile Acute Care for Elders (MACE) consultation at a Veterans Affairs Medical Center (VAMC). DESIGN Retrospective cohort analysis.
Derbigny, Wilbert A, Kumar, Ramesh
core +2 more sources
Current trends in oxysterol research [PDF]
, 2016 In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius +54 more
core +1 more source
Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis. [PDF]
, 2023 The vasculature is a key regulator of leukocyte trafficking into the central nervous system (CNS) during inflammatory diseases including multiple sclerosis (MS).
Boivin, G. +19 more
core +2 more sources
Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature [PDF]
, 2014 BACKGROUND: Aging is accompanied by increasing vulnerability to pathologies such as atherosclerosis (ATH) and Alzheimer disease (AD). Are these different pathologies, or different presentations with a similar underlying pathoetiology?
Alexandra Sapronova +2 more
core +1 more source
Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems [PDF]
, 2011 Background Understanding host response to influenza virus infection will facilitate development of better diagnoses and therapeutic interventions.
Jason E McDermott +10 more
core +1 more source
Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium [PDF]
, 2013 BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct
Ashton, Kevin J. +6 more
core +7 more sources
High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3 [PDF]
, 2014 High Density Lipoprotein (HDL) mediates reverse cholesterol transport and it is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory ...
Beyer, Marc +26 more
core +1 more source