trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales +1 more
doaj +1 more source
Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. [PDF]
PLoS ONE, 2018 Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva +13 more
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Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood.
Elham Karimi Sales +3 more
doaj +1 more source
Analysis of Chalcone Synthase and Chalcone Isomerase Gene Expression in Pigment Production Pathway at Different Flower Colors of Petunia Hybrida [PDF]
Journal of Cell and Molecular Research, 2016 Variegation in flower color is commonly observed in many plant species and also occurs on petunia (Petunia hybrida) as an ornamental plant. Variegated plants are highly valuable in the floricultural market.
fatemeh keykha +2 more
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Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH.
Elham Karimi-Sales +3 more
doaj +1 more source
Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent
Molecules, 2021 Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region.
Lucia Wiwid Wijayanti +3 more
doaj +1 more source
Molecules, 2023 Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity.
Mahmoud I. M. Darwish +10 more
doaj +1 more source
A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells
Journal of International Medical Research, 2020 Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and ...
Jie Chen +4 more
doaj +1 more source
Hepatoprotective and antifibrotic effects of trans-chalcone against bile duct ligation-induced liver fibrosis in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Several lines of research have shown that hepatic fibrosis is one of the leading causes of death worldwide. Trans-chalcone is a flavonoid precursor with anti-oxidant and anti-inflammatory effects.
Faezeh Javadi +5 more
doaj +1 more source
Indonesian Journal of Chemistry, 2018 The synthesis of chalcone derivatives as target compounds and anticancer test against breast (T47D) and colon (WiDr) cell line had been performed.
Chairil Anwar +5 more
doaj +1 more source