Results 1 to 10 of about 28,625 (273)

Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone [PDF]

MethodsX
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho, A. Caeiro, H.C. Sousa, M.E.M. Braga, M.G. Campos   +4 more
doaj   +2 more sources

Synthesis of Anti-Inflammatory Drugs’ Chalcone Derivatives and a Study of Their Conformational Properties Through a Combination of Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling [PDF]

Pharmaceuticals
Background: In this study, two chalcone analogs were synthesized through in silico and experimental methods, and their potential to inhibit the lipoxygenase enzyme, which plays a role in the inflammation pathway, was assessed. Specifically, this study is
Nikitas Georgiou, Andromachi Tzani, Kyriaki Vavougyiou, Christos Papadopoulos, Nikolaos Eleftheriadis, Primož Šket, Demeter Tzeli, Tuomas Niemi-Aro, Anastasia Detsi, Thomas Mavromoustakos   +9 more
doaj   +2 more sources

trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales, Mohammad Reza Alipour   +1 more
doaj   +1 more source

Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. [PDF]

PLoS ONE, 2018
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva, Mozart Marins, Nadda Chaichanasak, Yongdae Yoon, Ana Lúcia Fachin, Vitor Caressato Pinhanelli, Luis Octávio Regasini, Mariana Bastos Dos Santos, Gabriela Miranda Ayusso, Beatriz de Carvalho Marques, Wells W Wu, Je-Nie Phue, Rong-Fong Shen, Seung Joon Baek   +13 more
doaj   +1 more source

Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood.
Elham Karimi Sales, Sajad Jeddi, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour   +3 more
doaj   +1 more source

Analysis of Chalcone Synthase and Chalcone Isomerase Gene Expression in Pigment Production Pathway at Different Flower Colors of Petunia Hybrida [PDF]

Journal of Cell and Molecular Research, 2016
Variegation in flower color is commonly observed in many plant species and also occurs on petunia (Petunia hybrida) as an ornamental plant. Variegated plants are highly valuable in the floricultural market.
fatemeh keykha, Abdol Reza Bagheri, Nasrin Moshtaghi   +2 more
doaj   +1 more source

A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells

Journal of International Medical Research, 2020
Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and ...
Jie Chen, Chun-Yan Kang, Zhao-Xia Niu, Hui-Cong Zhou, Hong-Mei Yang   +4 more
doaj   +1 more source

Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis

Molecules, 2023
Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity.
Mahmoud I. M. Darwish, Ahmed M. Moustafa, Asmaa M. Youssef, Mohamed Mansour, Ahmed I. Yousef, Abdelfatteh El Omri, Hossam H. Shawki, Magda F. Mohamed, Hamdi M. Hassaneen, Ismail A. Abdelhamid, Hisashi Oishi   +10 more
doaj   +1 more source

Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH.
Elham Karimi-Sales, Sajad Jeddi, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour   +3 more
doaj   +1 more source

Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent

Molecules, 2021
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region.
Lucia Wiwid Wijayanti, Respati Tri Swasono, Wonkoo Lee, Jumina Jumina   +3 more
doaj   +1 more source