Results 1 to 10 of about 74,636 (287)
Nature Communications, 2020 Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al.
Toshiyuki Waki +20 more
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Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent
Molecules, 2021 Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region.
Lucia Wiwid Wijayanti +3 more
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Antiproliferative Effect of Acridine Chalcone Is Mediated by Induction of Oxidative Stress
Biomolecules, 2020 Chalcones are naturally occurring phytochemicals with diverse biological activities including antioxidant, antiproliferative, and anticancer effects. Some studies indicate that the antiproliferative effect of chalcones may be associated with their pro ...
Peter Takac +6 more
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Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone [PDF]
MethodsXIn this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho +4 more
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SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be
Raed Shalaby +8 more
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trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales +1 more
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ACS Omega, 2023 The incorporation of heterocyclic moieties into the standard chemical structure with a biologically active scaffold has become of crucial practice for the construction of pharmacologically potent candidates in the drug arena. Currently, numerous kinds of
Kibrom Mezgebe +2 more
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ACS Omega, 2023 The density functional theory (DFT) method using the functional hybrid (B3LYP) and 6-311G(d,p) basis set was utilized for the geometry optimization with dispersion correction, procedure (GO + DC), for the E and Z chalcone isomers -1-(4-aminophenyl)- 3-(i,
Haval A. Hussein, G. Fadhil
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Chalcone Derivatives: Role in Anticancer Therapy
Biomolecules, 2021 Chalcones (1,3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids, which are common simple chemical scaffolds found in many naturally occurring compounds. Many chalcone derivatives were also prepared due to their convenient synthesis.
Ouyang Yang +5 more
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Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives
Molecules, 2022 Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties.
J. Dhaliwal +11 more
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