The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020 Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting +8 more
openaire +5 more sources
Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. [PDF]
PLoS ONE, 2018 Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva +13 more
doaj +1 more source
Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood.
Elham Karimi Sales +3 more
doaj +1 more source
Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
Pharmaceuticals, 2022 Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior ...
Gayathri Rajendran +9 more
semanticscholar +1 more source
Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics
Molecules, 2021 Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids.
M. Rudrapal +7 more
semanticscholar +1 more source
Analysis of Chalcone Synthase and Chalcone Isomerase Gene Expression in Pigment Production Pathway at Different Flower Colors of Petunia Hybrida [PDF]
Journal of Cell and Molecular Research, 2016 Variegation in flower color is commonly observed in many plant species and also occurs on petunia (Petunia hybrida) as an ornamental plant. Variegated plants are highly valuable in the floricultural market.
fatemeh keykha +2 more
doaj +1 more source
Chalcone Derivatives with a High Potential as Multifunctional Antioxidant Neuroprotectors
ACS Omega, 2022 A systematic, rational search for chalcone derivatives with multifunctional behavior has been carried out, with the support of a computer-assisted protocol (CADMA-Chem).
Adriana Pérez-González +4 more
semanticscholar +1 more source
Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors
International Journal of Molecular Sciences, 2022 Due to the multifaceted pharmacological activities of chalcones, these scaffolds have been considered one of the most privileged frameworks in the drug discovery process. Structurally, chalcones are α, β-unsaturated carbonyl functionalities with two aryl
Ginson George +7 more
semanticscholar +1 more source
New chalcone derivatives as potential antimicrobial and antioxidant agent
Scientific Reports, 2021 Seven chalcone derivatives were synthesized by the Claisen-Schmidt condensation. The structures of the compounds were confirmed by spectral data (Ultraviolet/visible, infrared, nuclear magnetic resonance and mass spectroscopy).
Emelda N Okolo +7 more
semanticscholar +1 more source
Materials Chemistry Frontiers, 2021 Four series of novel bis-chalcone compounds with excellent performances have been synthesized and examined for the first time as photoinitiators in combination with an amine and an iodonium salt for the FRP of acrylates and the CP of EPOX.
Hong Chen +11 more
semanticscholar +1 more source