Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model [PDF]
Molecules, 2014 [[abstract]]The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological ...
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trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales +1 more
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The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020 Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting +8 more
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Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. [PDF]
PLoS ONE, 2018 Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
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Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood.
Elham Karimi Sales +3 more
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Analysis of Chalcone Synthase and Chalcone Isomerase Gene Expression in Pigment Production Pathway at Different Flower Colors of Petunia Hybrida [PDF]
Journal of Cell and Molecular Research, 2016 Variegation in flower color is commonly observed in many plant species and also occurs on petunia (Petunia hybrida) as an ornamental plant. Variegated plants are highly valuable in the floricultural market.
fatemeh keykha +2 more
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A Glimpse of the Molecule Chalcone
Future Journal of Pharmaceuticals and Health Sciences, 2021 The compound chalcone is very common which can available by synthetic means and naturally occurring from plant sources. These compounds have predominant value for their abundant properties with less adverse impacts on biological systems. The naturally occurring chalcone belongs to the flavonoid family.
Monapati Suchitra +2 more
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Synthesis of isoprenyl chalcone "sophoradin"
Agricultural and Biological Chemistry, 1974 Kazuaki Kyogoku +4 more
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Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase
Journal of Natural Products, 2023 By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation-thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a C-terminal thioesterase domain was involved in the Claisen-type cyclization.
Sho Furumura +7 more
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Molecules, 2023 Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity.
Mahmoud I. M. Darwish +10 more
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