Results 21 to 30 of about 74,636 (287)
Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH.
Elham Karimi-Sales +3 more
doaj +1 more source
A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Microtubules play an important role in the process of cell mitosis and can form a spindle in the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then divide into two daughter cells to complete the process of mitosis ...
Wenjing Liu +4 more
semanticscholar +1 more source
Molecules, 2021 Compounds bearing thiazole and chalcone pharmacophores have been reported to possess excellent antitubercular and anticancer activities. In view of this, we designed, synthesized and characterized a novel series of thiazole–chalcone hybrids (1–20) and ...
Ashok Babu Kasetti +4 more
semanticscholar +1 more source
Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase
Journal of Natural Products, 2023 By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation-thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a C-terminal thioesterase domain was involved in the Claisen-type cyclization.
Sho Furumura +7 more
openaire +2 more sources
Molecules, 2023 Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity.
Mahmoud I. M. Darwish +10 more
doaj +1 more source
A Glimpse of the Molecule Chalcone
Future Journal of Pharmaceuticals and Health Sciences, 2021 The compound chalcone is very common which can available by synthetic means and naturally occurring from plant sources. These compounds have predominant value for their abundant properties with less adverse impacts on biological systems. The naturally occurring chalcone belongs to the flavonoid family.
Monapati Suchitra +2 more
openaire +2 more sources
Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]
, 2020 Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi +5 more
core +2 more sources
A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells
Journal of International Medical Research, 2020 Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and ...
Jie Chen +4 more
doaj +1 more source
, 2021 The human skin is pivotal for protecting the body from various stresses and diseases, regulating several physiological aspects, and sensing any signal changes around the environment. To work and function optimally, the skin should be protected and cared regularly by using some treatments.
Jumina +2 more
openaire +3 more sources
Hepatoprotective and antifibrotic effects of trans-chalcone against bile duct ligation-induced liver fibrosis in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Several lines of research have shown that hepatic fibrosis is one of the leading causes of death worldwide. Trans-chalcone is a flavonoid precursor with anti-oxidant and anti-inflammatory effects.
Faezeh Javadi +5 more
doaj +1 more source