Results 31 to 40 of about 28,625 (273)
Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model [PDF]
Molecules, 2014 The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment.
Ching Yuh Chern +6 more
openaire +3 more sources
Bangladesh Journal of Pharmacology, 2016 The aim of the current study was to investigate the in vitro and in vivo anti-tumor effects of naringenin chalcone in U87MG human glioblastoma cells and in xenograft mice model.
Shuai Zhang +4 more
doaj +1 more source
Chempublish Journal, 2023 Molecular docking study of 6 chalcone analogues with protein target from the crystallographic structure modeling of Bcl-2 protein with PDB code 2W3L was carried out using computational media using the Molecular Operating Environment (MOE) program.
Neni Frimayanti +2 more
doaj +1 more source
Natural Product Rottlerin Derivatives Targeting Quorum Sensing
Molecules, 2021 Rottlerin is a natural product consisting of chalcone and flavonoid scaffolds, both of which have previously shown quorum sensing (QS) inhibition in various bacteria.
Dittu Suresh +6 more
doaj +1 more source
Machine Learning-based Analysis of Electronic Properties as Predictors of Anticholinesterase Activity in Chalcone Derivatives [PDF]
arXiv, 2023 In this study, we investigated the correlation between the electronic properties of anticholinesterase compounds and their biological activity. While the methodology of such correlation is well-established and has been effectively utilized in previous studies, we employed a more sophisticated approach: machine learning.
arxiv
Green Synthesis of Chalcone Derivatives Using Chalcones as Precursor
, 2022 Recently, the use of green methodologies like sonication, use of ionic liquids, etc. attracted the attention of researchers in the field of organic synthesis as they have advantages such as mild reaction conditions, environmentally benign procedures, etc.
Surbhi, Dhadda, +2 more
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Regulation of autophagy-related gene expressions by Trans-chalcone in the lungs of adult male rats [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Autophagy is responsible for maintaining cellular homeostasis by degrading and recycling macromolecules and unwanted intracellular components, such as damaged organelles.
Fatemeh Salehi Mazdeh +4 more
doaj +1 more source
Antibiotics, 2022 Naringenin and its glycosylated derivative naringin are flavonoids that are synthesized by the phenylpropanoid pathway in plants. We found that naringenin is also formed by the actinobacterium Streptomyces clavuligerus, a well-known microorganism used to
Juan F. Martín, Paloma Liras
doaj +1 more source
Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model [PDF]
Molecules, 2013 The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically.
Yau-Hung Chen +5 more
openaire +3 more sources
SYNTHESIS AND CYTOTOXIC ACTIVITY OF CHALCONE DERIVATIVES ON HUMAN BREAST CANCER CELL LINES
Indonesian Journal of Chemistry, 2012 Chalcone, an α,β-unsaturated ketone, has been shown have many biological activities such as anticancer and antifungi. This research was conducted to synthesize the chalcone derivatives and to obtain their cytotoxic activity on human cervix cancer cell ...
Nuraini Harmastuti +4 more
doaj +1 more source