Results 131 to 140 of about 54,606 (348)

α,β‐Alkylation Reactions Catalyzed by Ruthenium Triphenylphosphine Complexes Bearing Substituted Pyridine–Quinoline Based Ligands

European Journal of Inorganic Chemistry, EarlyView.
A series of new air‐stable ruthenium(II) bis‐triphenylphosphine complexes comprising substituted pyridine–quinoline ligands have been developed via a one‐pot procedure. The new complexes successfully serve as scaffolds to promote catalytic CC bond formation, more precisely the α‐alkylation of ketones with primary alcohols, via the borrowing hydrogen ...
Nikolaos Zacharopoulos, Panagiotis‐Georgios Kanellopoulos, Evangelos Bakeas, Antigoni Cheilari, Gregor Schnakenburg, Athanassios Chrissanthopoulos, Athanassios Philippopoulos   +6 more
wiley   +1 more source

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells [PDF]

, 2019
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency.
Evans, David, Fernández-Bolaños Guzmán, José María, López López, Óscar, Man,Teresa, Martins, Alice, Matos, Ana M. de, Oliveira, Maria Conceição, Rauter, Amélia P., Walter, Magnus   +8 more
core   +1 more source

Decarboxylative Michael Additions of Substituted Malonic Acid Half‐Oxyesters to Methylidene Malonates

European Journal of Organic Chemistry, EarlyView.
Substituted malonic acid half oxyesters reacted with alkylidene malonates in a fast, efficient decarboxylative Michael addition, delivering adducts in high yields. The reaction occurred in bulk solvent, open to air, needing only a weak amine base as an organocatalyst to drive a mechanism involving addition prior to decarboxylation.
Marine Pinaud, Tania Xavier, Léa Lin, Erwan Le Gall, Marc Presset   +4 more
wiley   +1 more source

Synthesis and Preliminary Evaluation of Several Chalcone Derivatives as Sunscreen Compounds

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2019
Four chalcone derivatives were synthesized and pre-evaluated as broad-spectrum UV protector. Chalcones 1-4 showed a wide range of UV absorbance values and moderate molar absorptivity values. Chalcones 3 and 4 showed better photostability than chalcones 1
Jumina Jumina, Rizky Woro Styaningrum, Dwi Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, Eti Nurwening Sholikhah, Abdul Karim Zulkarnain   +7 more
doaj   +1 more source

The role of phenolic compounds in the fight against cancer – a review [PDF]

, 2013
Cancer is a worldwide scourge; it’s the leading cause of death in developed countries and is increasing in developing countries. Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of
Carocho, Márcio, Ferreira, Isabel C.F.R.   +1 more
core   +1 more source

STIP1 drives Metabolic Reprogramming in Esophageal Squamous Cell Carcinoma via AHCY‐LDHA Axis

Exploration, EarlyView.
A schematic model illustrating that LCA can inhibit ESCC growth by inhibiting the STIP1/AHCY/LDHA axis. In brief. Jin et al. demonstrated that targeting STIP1 can significantly inhibit the progression of esophageal squamous cell carcinoma. The high expression of STIP1 increased the interaction between AHCY and LDHA and then AHCY recruits PRMT3 to ...
Guoguo Jin, Yanming Song, Mingyang Yan, Shaobo Fang, Yang Shao, Kexin Zhao, Meng Liu, Qinxin Guo, Xinyang Jia, Chengjuan Zhang, Zhenwei Wang, Kangdong Liu, Xiang Li, Simin Zhao, Mee‐Hyun Lee, Zhiping Guo, Zigang Dong   +16 more
wiley   +1 more source

Stenotrophomonas maltophilia: A Gram-Negative Bacterium Useful for Transformations of Flavanone and Chalcone

Molecules, 2017
A group of flavones, isoflavones, flavanones, and chalcones was subjected to small-scale biotransformation studies with the Gram-negative Stenotrophomonas maltophilia KB2 strain in order to evaluate the capability of this strain to transform flavonoid ...
Edyta Kostrzewa-Susłow, Monika Dymarska, Urszula Guzik, Danuta Wojcieszyńska, Tomasz Janeczko   +4 more
doaj   +1 more source

A Multifaceted Review on Neodiosmin In Planta Distribution, (Bio)synthesis, Food and Health Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Neodiosmin (NEO) is a major glycosylated flavone that is derived from the bitter flavanone neo‐hesperidin in citrus fruits including orange, lime, and lemon. One of the most important features of NEO is that it exerts a notable debittering effect on plant flavonoids justifying its wide use as a food additive.
Yuxuan Zhao, Jingyimei Liang, Xincheng Wu, Mohamed A. Farag, Predrag Putnik   +4 more
wiley   +1 more source

Halo-Substituted Chalcones and Azachalcones-Inhibited, Lipopolysaccharited-Stimulated, Pro-Inflammatory Responses through the TLR4-Mediated Pathway

Molecules, 2018
A series of B-ring, halo-substituted chalcones and azachalcones were synthesized to evaluate and compare their anti-inflammatory activity. Mouse BALB/c macrophage RAW 264.7 were pre-treated with 10 μg/mL of each compound for one hour before induction of ...
Tzenge-Lien Shih, Ming-Hwa Liu, Chia-Wai Li, Chia-Feng Kuo   +3 more
doaj   +1 more source

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source