Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold [PDF]
, 2019 The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol ...
Cidade, Honorina +12 more
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Advances in the Synthesis of Heteroaromatic Hybrid Chalcones
Molecules, 2023 Chalcones continue to occupy a venerated status as scaffolds for the construction of a variety of heterocyclic molecules with medicinal and industrial properties. Syntheses of hybrid chalcones featuring heteroaromatic components, especially those methods
Ajay Mallia, Joseph Sloop
doaj +1 more source
Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. [PDF]
, 2017 Angelica keiskei (Miq.) Koidz. (Umbelliferae) has traditionally been used to treat dysuria, dyschezia, and dysgalactia as well as to restore vitality. Recently, the aerial parts of A. keiskei have been consumed as a health food.
Jafari, Mahtab +3 more
core +1 more source
Study of Michael addition on chalcones and or chalcone analogues
Journal of Saudi Chemical Society, 2012 AbstractMichael addition reaction of 1,3-diphenyl-propenone 1a, e, and f with o-amino thiophenol in the presence of indium trichloride gave the benzothiazine derivatives 2a–c. Condensation of the compound 1a, e with o-phenylene diamine in triethylamine gave the benzodiazepine derivatives 3a–b.
Makarem M.S. Karah +2 more
openaire +2 more sources
A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]
, 2017 The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao +9 more
core +2 more sources
Molecules, 2021 Over the past several decades, photopolymerization has become an active research field, and the ongoing efforts to develop new photoinitiating systems are supported by the different applications in which this polymerization technique is involved ...
Nicolas Giacoletto, Frédéric Dumur
doaj +1 more source
Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2Hchromen-2-one Derivatives [PDF]
, 2010 The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic ...
Ajani +47 more
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Manganese carbonyl-mediated reactions of azabutadienes with phenylacetylene, methyl acrylate and other unsaturated molecules [PDF]
, 2004 Reaction of PhCH₂Mn(CO)₅ with l,4-di-aryl-1-aza-1,3-butadienes gave substituted pyrrolinonyl rings which were η⁴-coordinated to a Mn(CO)₃ group. These are formed by intramolecular CO insertion into a (non-isolated) cyclomanganated intermediate, followed ...
Mace, Wade +3 more
core +2 more sources
A comprehensive review on the antiviral activities of chalcones
Journal of drug targeting (Print), 2020 Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that can overcome the limitations of ...
Dana Elkhalifa +3 more
semanticscholar +1 more source
Chalcones identify cTXNPx as a potential antileishmanial drug target
PLoS Neglected Tropical Diseases, 2021 With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets.
Douglas O Escrivani +14 more
semanticscholar +1 more source