Results 41 to 50 of about 53,724 (334)

Chalcones in Dermatology

, 2021
The human skin is pivotal for protecting the body from various stresses and diseases, regulating several physiological aspects, and sensing any signal changes around the environment. To work and function optimally, the skin should be protected and cared regularly by using some treatments.
Jumina, Harizal, Yehezkiel Steven Kurniawan   +2 more
openaire   +3 more sources

Chalcones identify cTXNPx as a potential antileishmanial drug target

PLoS Neglected Tropical Diseases, 2021
With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets.
Douglas O Escrivani, Rebecca L Charlton, M. B. Caruso, G. Burle-Caldas, M. Borsodi, R. Zingali, Marcos V. Palmeira-Mello, Jéssica B de Jesus, Alessandra M T Souza, Bárbara Abrahim-Vieira, S. Freitag-Pohl, E. Pohl, P. Denny, B. Rossi-Bergmann, P. Steel   +14 more
semanticscholar   +1 more source

Design and Synthesis of Pyridyl and 2-Hydroxyphenyl Chalcones with Antitubercular Activity. [PDF]

Molecules
A focussed library of pyridyl and 2-hydroxyphenyl chalcones were synthesized and tested for growth inhibitory activity against Mycobacterium tuberculosis H37Rv, and normal and cancer breast cell lines.
Aziafor K, Ruparelia K, Moulds B, Zloh M, Parish T, Brucoli F.   +5 more
europepmc   +2 more sources

Study of Michael addition on chalcones and or chalcone analogues

Journal of Saudi Chemical Society, 2012
AbstractMichael addition reaction of 1,3-diphenyl-propenone 1a, e, and f with o-amino thiophenol in the presence of indium trichloride gave the benzothiazine derivatives 2a–c. Condensation of the compound 1a, e with o-phenylene diamine in triethylamine gave the benzodiazepine derivatives 3a–b.
Makarem M.S. Karah, Amal S.A. Bougasim, Nabila A. Al-Jaber   +2 more
openaire   +2 more sources

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles

Pharmaceutics, 2023
Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing ...
Soufyane Hba, Suzan Ghaddar, Hicham Wahnou, Aline Pinon, Riad El Kebbaj, Christelle Pouget, Vincent Sol, Bertrand Liagre, Mounia Oudghiri, Youness Limami   +9 more
doaj   +1 more source

A comprehensive review on the antiviral activities of chalcones

Journal of drug targeting (Print), 2020
Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that can overcome the limitations of ...
Dana Elkhalifa, Israa Al-Hashimi, A. Al Moustafa, Ashraf Khalil   +3 more
semanticscholar   +1 more source

Steroidal chalcones and derivatives: a review

Arkivoc, 2021
It was observed that the presence of heterocycles to steroids often leads to a change in their physiological activity and the appearance of new interesting biological precursors. Recent developments in the syntheses of steroidal chalcones and their derivatives are described herein. The biological activities of those steroidal derivatives for which data
Ibrahim-Ouali, Malika, Dumur, Frédéric
openaire   +4 more sources

Natural Chalcones in Chinese Materia Medica: Licorice

Evidence-Based Complementary and Alternative Medicine, 2020
Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely ...
Danni Wang, Jing Liang, Jing Zhang, Yuefei Wang, X. Chai   +4 more
semanticscholar   +1 more source

Phthalocyanine-chalcone conjugates

Journal of Porphyrins and Phthalocyanines, 2016
A phthalocyanine-chalcone conjugate was previously reported to retain the full photodynamic activity of the phthalocyanine and a slightly lowered antivascular effect of the chalcone. Assuming that it was due to an insufficient release of the chalcone, we described here several grafting modes applied to the preparation of phthalocyanine-chalcone ...
Khalil Bennis, Khalil Bennis, Derya Topkaya, Derya Topkaya, Serkan Alpugan, Vefa Ahsen, Charlene Vey, Charlene Vey, Jérémie Fournier-dit-Chabert, Jérémie Fournier-dit-Chabert, Mélissa Cucca, Mélissa Cucca, Sinem Tuncel Kostakoğlu, Sebile Işık Büyükekşi, Gökçe Canan Taşkın, Florian Albrieux, Ayşe Gül Gürek, Devrim Atilla, Fallia Aribi, Fallia Aribi, Fabienne Dumoulin, Sylvie Ducki, Sylvie Ducki   +22 more
openaire   +6 more sources

Synthesis of Chalcones with Anticancer Activities [PDF]

Molecules, 2012
Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and human normal liver cell line WRL-68 was evaluated. Most of
Suvitha Syam, Siddig Ibrahim Abdelwahab, Mohammed Ali Al-Mamary, Syam Mohan   +3 more
openaire   +4 more sources