Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase
Journal of Natural Products, 2023 By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation-thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a C-terminal thioesterase domain was involved in the Claisen-type cyclization.
Sho Furumura +7 more
openaire +2 more sources
Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. [PDF]
, 2012 Angiogenesis, the growth of new blood vessels, is necessary for cancerous tumors to keep growing and spreading. Suppression of abnormal angiogenesis may provide therapeutic strategies for the treatment of angiogenesis-dependent disorders.
Belleri M +8 more
core +1 more source
Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
E-Journal of Chemistry, 2011 Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones.
CH. Sridevi, K. Balaji, A. Naidu
doaj +1 more source
Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin [PDF]
, 2017 Indexación: Web of Science; Scopus.An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS.
Escobar, B. +6 more
core +5 more sources
Mechanochemical synthesis of indolyl chalcones with antiproliferative activity
Green Chemistry Letters and Reviews, 2022 An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen–Schmidt condensation of 1-methylindole-3-carboxaldehyde with various substituted acetophenones is described using liquid assisted grinding in a high ...
Zuzana Kudličková +4 more
doaj +1 more source
Differentiation of argentine propolis from different species of bees and geographical origins by UV spectroscopy and chemometric analysis [PDF]
, 2018 Bees collect vegetal resins that they mix with their wax and mechanical impurities to elaborate propolis, whose chemical composition is complex and variable depending on botanical/geographical origin, type of bee, time of year when it was produced and ...
Borelli, Romina +7 more
core +2 more sources
Thermal study of chalcones [PDF]
Journal of Thermal Analysis and Calorimetry, 2018 Chalcones α-β-unsaturated ketones are found in large plant species. Synthesis of chalcones and its three analogues hydroxy group at 2′, 3′ and 4′ positions (2–4) was carried out. The studies of thermal behavior were made by thermogravimetry (TG) and differential scanning calorimetry, both under oxygen and nitrogen purge gases.
Marcelo Kobelnik +5 more
openaire +2 more sources
Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model [PDF]
, 2014 [[abstract]]The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological ...
Ajaiyeoba +9 more
core +2 more sources
The [4+2]‐Cycloaddition of α‐Nitrosoalkenes with Thiochalcones as a Prototype of Periselective Hetero‐Diels–Alder Reactions—Experimental and Computational Studies [PDF]
, 2020 The [4+2]‐cycloadditions of α‐nitrosoalkenes with thiochalcones occur with high selectivity at the thioketone moiety of the dienophile providing styryl‐substituted 4H‐1,5,2‐oxathiazines in moderate to good yields.
Boger D. L. +8 more
core +1 more source
Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC ...
Mariana Bastos dos Santos +10 more
doaj +1 more source