Results 11 to 20 of about 9,035 (197)
Kidney International, 2000 Calcium is an important intracellular signaling molecule, and altered calcium channel function can cause widespread cellular changes. Genetic mutations in calcium channels that cause what appear to be trivial alterations of calcium currents in vitro can result in serious diseases in muscles and the nervous system.
Lorenzon, Nancy M., Beam, Kurt G.
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The renal channelopathies [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2014 Specific channels permit movement of selected ions through cellular membranes, and are of vital importance in a number of physiological processes, particularly in excitable tissues such as nerve and muscle, but also in endocrine organs and in epithelial biology.
K W, Loudon, A C, Fry
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TRPM3 in Brain (Patho)Physiology
Frontiers in Cell and Developmental Biology, 2021 Already for centuries, humankind is driven to understand the physiological and pathological mechanisms that occur in our brains. Today, we know that ion channels play an essential role in the regulation of neural processes and control many functions of ...
Katharina Held +2 more
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Cells, 2021 Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Nav1.6 is highly enriched at the axon
Agnes Zybura +2 more
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Neurological channelopathies [PDF]
Postgraduate Medical Journal, 2005 Abstract Ion channels are membrane-bound proteins that perform key functions in virtually all human cells. Such channels are critically important for the normal function of the excitable tissues of the nervous system, such as muscle and brain.
T D, Graves, M G, Hanna
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Mammalian Brain Ca2+ Channel Activity Transplanted into Xenopus laevis Oocytes
Membranes, 2022 Several mutations on neuronal voltage-gated Ca2+ channels (VGCC) have been shown to cause neurological disorders and contribute to the initiation of epileptic seizures, migraines, or cerebellar degeneration.
Matthieu Rousset +7 more
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Journal of Clinical Investigation, 2010 Mendelian heritable pain disorders have provided insights into human pain mechanisms and suggested new analgesic drug targets. Interestingly, many of the heritable monogenic pain disorders have been mapped to mutations in genes encoding ion channels. Studies in transgenic mice have also implicated many ion channels in damage sensing and pain modulation.
Raouf, Ramin +2 more
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Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome
Frontiers in Pediatrics, 2021 Background: Sudden infant death syndrome (SIDS) is a tragic incident which remains a mystery even after post-mortem investigation and thorough researches.Methods: This comprehensive review is based on the genes reported in the molecular autopsy studies ...
Riffat Mehboob +14 more
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Frontiers in Cellular Neuroscience, 2019 Transplantation of bone marrow stromal cells (BMSCs) is a promising therapy for ischemic stroke. Previously, we had reported that the secondary degeneration occurred in the ipsilateral substantia nigra (SN) after permanent distal branch of middle ...
Jizi Jin +13 more
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Medicina, 2021 The prediction and prevention of sudden cardiac death is the philosopher’s stone of clinical cardiac electrophysiology. Sports can act as triggers of fatal arrhythmias and therefore it is essential to promptly frame the athlete at risk and to carefully ...
Giovanni Volpato +16 more
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