Results 21 to 30 of about 11,955 (223)
The renal channelopathies [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2014 Specific channels permit movement of selected ions through cellular membranes, and are of vital importance in a number of physiological processes, particularly in excitable tissues such as nerve and muscle, but also in endocrine organs and in epithelial biology.
K W, Loudon, A C, Fry
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Inherited arrhythmia syndrome predisposing to sudden cardiac death [PDF]
The Korean Journal of Internal Medicine, 2021 Inherited arrhythmia (IA) is one of the main causes of sudden cardiac death (SCD) in young people, and is reported to be a more prevalent cause of SCD in Asia than in Western countries.
Yun Gi Kim +3 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Sudden cardiac arrest is the leading mode of death in the United States. Epilepsy affects 1% of Americans; yet epidemiological data show a prevalence of 4% in cases of sudden cardiac arrest.
C. Anwar A. Chahal +17 more
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Frontiers in Cellular Neuroscience, 2019 Transplantation of bone marrow stromal cells (BMSCs) is a promising therapy for ischemic stroke. Previously, we had reported that the secondary degeneration occurred in the ipsilateral substantia nigra (SN) after permanent distal branch of middle ...
Jizi Jin +13 more
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Frontiers in Cardiovascular Medicine, 2022 Disease modeling using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has both challenges and promise. While patient-derived iPSC-CMs provide a unique opportunity for disease modeling with isogenic cells, the challenge is that ...
Louise Reilly +4 more
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risk stratification of cardiac channelopathies
, 2023 Channelopathies are the leading causes of SCD in patients without structural heart disease. Missing the diagnosis of high-risk but concealed channelopathies could have lethal clinical consequences.
Chan, Kit, Kit Chan
core +1 more source
Journal of Clinical Investigation, 2010 Mendelian heritable pain disorders have provided insights into human pain mechanisms and suggested new analgesic drug targets. Interestingly, many of the heritable monogenic pain disorders have been mapped to mutations in genes encoding ion channels. Studies in transgenic mice have also implicated many ion channels in damage sensing and pain modulation.
Raouf, Ramin +2 more
openaire +3 more sources
Frontiers in Neurology, 2020 Myotonic disorders are inherited neuromuscular diseases divided into dystrophic myotonias and non-dystrophic myotonias (NDM). The latter is a group of dominant or recessive diseases caused by mutations in genes encoding ion channels that participate in ...
Fernando Morales, Michael Pusch
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Viruses, 2020 Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of which ...
Frank W. Charlton +6 more
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Stroke-Like Episodes in PMM2-CDG: When the Lack of Other Evidence Is the Only Evidence
Frontiers in Pediatrics, 2021 Phosphomannomutase 2 deficiency (PMM2-CDG) is the most frequent congenital disorder of glycosylation. PMM2-CDG patients develop chronic cerebellar atrophy as a neurological hallmark.
Mercedes Serrano, Mercedes Serrano
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