Results 171 to 180 of about 226,086 (342)

Phenylboronic acids as pH-selective ligands for arylsulfatase B: a lead for pharmacological chaperones against Maroteaux–Lamy syndrome [PDF]

Fumika Karaki, Kyoko Hidaka, Yuko Nishiyama, Ayuko Taniguchi, Yuichi Hashimoto, Kenji Ohgane, H. Fujii   +6 more
openalex   +1 more source

Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis [PDF]

, 2011
Takamitsu Miyayama, Yudai Ishizuka, Tomomi Iijima, Daisuke Hiraoka, Yasumitsu Ogra   +4 more
openalex   +1 more source

Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat.

New England Journal of Medicine, 2016
D. Germain, D. Hughes, K. Nicholls, D. Bichet, R. Giugliani, W. Wilcox, C. Feliciani, S. Shankar, F. Ezgü, H. Amartino, D. Bratkovic, U. Feldt-Rasmussen, K. Nedd, U. Din, C. Lourenço, M. Banikazemi, J. Charrow, M. Dasouki, D. Finegold, P. Giraldo, O. Goker-Alpan, N. Longo, C. Scott, R. Torra, A. Tuffaha, A. Jovanović, S. Waldek, S. Packman, E. Ludington, C. Viereck, J. Kirk, Julie Yu, E. Benjamin, F. Johnson, D. Lockhart, N. Skuban, J. Castelli, J. Barth, C. Barlow, Raphael Schiffmann, Raphael Schiffmann   +40 more
semanticscholar   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

NAD⁺ restores proteostasis through splicing-dependent autophagy. [PDF]

Autophagy
Ai R, Fang EF.
europepmc   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Delivery of a Hepatitis C Virus Vaccine Encoding NS3 Linked to the MHC Class II Chaperone Protein Invariant Chain Using Bacterial Ghosts [PDF]

Yulang Chi, Shikun Zhang, Shouping Ji
openalex   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Distribution and evolutionary significance of the DnaK-DnaJ-GrpE (KJE) chaperone system in archaea. [PDF]

Cell Stress Chaperones
Rebeaud ME.
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source