Results 51 to 60 of about 226,086 (342)

Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumption

eLife, 2014
70-kDa Heat shock proteins are ATP-driven molecular chaperones that perform a myriad of essential cellular tasks. Although structural and biochemical studies have shed some light on their functional mechanism, the fundamental issue of the role of energy ...
Paolo De Los Rios, Alessandro Barducci
doaj   +1 more source

Differential Interactions of Molecular Chaperones and Yeast Prions

Journal of Fungi, 2022
Baker’s yeast Saccharomyces cerevisiae is an important model organism that is applied to study various aspects of eukaryotic cell biology. Prions in yeast are self-perpetuating heritable protein aggregates that can be leveraged to study the interaction ...
Yury A. Barbitoff, Andrew G. Matveenko, Galina A. Zhouravleva   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

eLife, 2017
Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for ...
Nadinath B Nillegoda, Antonia Stank, Duccio Malinverni, Niels Alberts, Anna Szlachcic, Alessandro Barducci, Paolo De Los Rios, Rebecca C Wade, Bernd Bukau   +8 more
doaj   +1 more source

A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions

Frontiers in Immunology, 2021
The interleukin-6 (IL-6)/IL-12 family of cytokines plays critical roles in the induction and regulation of innate and adaptive immune responses. Among the various cytokines, only this family has the unique characteristic of being composed of two distinct
Aruma Watanabe, Izuru Mizoguchi, Hideaki Hasegawa, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Yuma Furusaka, Ami Sekine, Satomi Miyakawa, Fumihiro Murakami, Mingli Xu, Toshihiko Yoneto, Takayuki Yoshimoto   +12 more
doaj   +1 more source

Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

Nature Structural & Molecular Biology, 2018
A network of molecular chaperones is known to bind proteins (‘clients’) and balance their folding, function and turnover. However, it is often unclear which chaperones are critical for selective recognition of individual clients. It is also not clear why
S. Mok, Carlo Condello, Rebecca Freilich, Anne T Gillies, Taylor Arhar, J. Oroz, Harindranath Kadavath, O. Julien, Victoria A. Assimon, J. N. Rauch, Bryan M. Dunyak, Jungsoon Lee, F. Tsai, Mark R. Wilson, M. Zweckstetter, C. Dickey, J. Gestwicki   +16 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Regulation of Dual Activity of Ascorbate Peroxidase 1 From Arabidopsis thaliana by Conformational Changes and Posttranslational Modifications

Frontiers in Plant Science, 2021
Ascorbate peroxidase (APX) is an important reactive oxygen species (ROS)-scavenging enzyme, which catalyzes the removal of hydrogen peroxide (H2O2) to prevent oxidative damage.
Shubhpreet Kaur, Shubhpreet Kaur, Prapti Prakash, Prapti Prakash, Dong-Ho Bak, Sung Hyun Hong, Chuloh Cho, Moon-Soo Chung, Jin-Hong Kim, Jin-Hong Kim, Sungbeom Lee, Sungbeom Lee, Hyoung-Woo Bai, Hyoung-Woo Bai, Sang Yeol Lee, Byung Yeoup Chung, Seung Sik Lee, Seung Sik Lee   +17 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source