Results 31 to 40 of about 158,532 (263)
Molecules, 2023 Various host systems have been employed to increase the yield of recombinant proteins. However, some recombinant proteins were successfully produced at high yields but with no functional activities. To achieve both high protein yield and high activities,
Juntratip Jomrit +2 more
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, 2010 The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood.
Dabbs, Rebecca A +4 more
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Co-chaperones are limiting in a depleted chaperone network [PDF]
Cellular and Molecular Life Sciences, 2010 To probe the limiting nodes in the chaperoning network which maintains cellular proteostasis, we expressed a dominant negative mutant of heat shock factor 1 (dnHSF1), the regulator of the cytoplasmic proteotoxic stress response. Microarray analysis of non-stressed dnHSF1 cells showed a two- or more fold decrease in the transcript level of 10 genes ...
Heldens, L. +6 more
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Inhibitors of the AAA+ Chaperone p97
Molecules, 2015 It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food and Drug Administration (FDA) more than 10 years ago to treat ...
Eli Chapman +3 more
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mBio, 2020 The bacterial pathogen Mycobacterium tuberculosis is the leading cause of death by an infectious disease among humans. Here, we describe a previously uncharacterized M.
Samuel H. Becker +9 more
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Molecular Chaperones and Co-Chaperones in Parkinson Disease [PDF]
The Neuroscientist, 2012 Parkinson disease, a progressive neurodegenerative disorder, is caused by the pathological accumulation of proteins, including the ubiquitous presynaptic protein α-synuclein. Alterations in the metabolism of α-synuclein have clearly been linked to neurodegeneration, and early steps in the pathological sequence of this protein include the formation of ...
Hemi, Dimant +2 more
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A Twist in Yeast: New Perspectives for Studying TDP-43 Proteinopathies in S. cerevisiae
Journal of FungiTAR DNA-binding protein 43 kDa (TDP-43) proteinopathies are a group of neurodegenerative diseases (NDs) characterized by the abnormal accumulation of the TDP-43 protein in neurons and glial cells.
Roberto Stella +3 more
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Frontiers in Microbiology, 2018 The HtrA family of serine proteases is found in most bacteria, and plays an essential role in the virulence of the gastric pathogen Helicobacter pylori. Secreted H.
Nicole Albrecht +4 more
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eLife, 2015 Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus alike ...
Yusuke Miyazaki +4 more
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Chaperone-assisted translocation [PDF]
Physical Biology, 2004 24 pages, 3 figures, LaTeX (IOP class file)
Ambjørnsson, T, Metzler, R
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