Results 21 to 30 of about 158,532 (263)

Myosin chaperones

Current Opinion in Structural Biology, 2014
The folding and assembly of myosin motor proteins is essential for most movement processes at the cellular, but also at the organism level. Importantly, myosins, which represent a very diverse family of proteins, require the activity of general and specialized folding factors to develop their full motor function.
Hellerschmied, Doris, Clausen, Tim
openaire   +2 more sources

Calreticulin: Roles in Cell-Surface Protein Expression

Membranes, 2014
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane ...
Yue Jiang, Sandeepa Dey, Hiroaki Matsunami   +2 more
doaj   +1 more source

Chaperoning erythropoiesis

Blood, 2009
AbstractMultisubunit complexes containing molecular chaperones regulate protein production, stability, and degradation in virtually every cell type. We are beginning to recognize how generalized and tissue-specific chaperones regulate specialized aspects of erythropoiesis.
Mitchell J, Weiss, Camila O, dos Santos
openaire   +3 more sources

HtrA chaperone activity contributes to host cell binding in Campylobacter jejuni

Gut Pathogens, 2011
Background Acute gastroenteritis caused by the food-borne pathogen Campylobacter jejuni is associated with attachment of bacteria to the intestinal epithelium and subsequent invasion of epithelial cells. In C.
Bæk Kristoffer T, Vegge Christina S, Brøndsted Lone   +2 more
doaj   +1 more source

Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

eLife, 2019
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely ...
David F Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikasz-Nagy, Martí Aldea   +5 more
doaj   +1 more source

Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cells

Frontiers in Pharmacology, 2023
Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype.
Naphannop Sereesongsaeng, James F. Burrows, Christopher J. Scott, Klaudia Brix, Roberta E. Burden   +4 more
doaj   +1 more source

Similarities and Differences of Hsp70, hsc70, Grp78 and Mortalin as Cancer Biomarkers and Drug Targets

Cells, 2021
Background: Upregulation of Heath Shock Protein 70 (HSP70) chaperones supports cancer cell survival. Their high homology causes a challenge to differentiate them in experimental or prevention and treatment strategies.
Rajani Rai, Amy L. Kennedy, Zitha Redempta Isingizwe, Pouya Javadian, Doris Mangiaracina Benbrook   +4 more
doaj   +1 more source

RNAs as chaperones [PDF]

RNA Biology, 2016
Recently, we found that RNA is a remarkably powerful chaperone that can bind to unfolded proteins and transfer them to Hsp70 for refolding. Combined with past studies on RNA-chaperone interactions, we propose a model for how chaperone RNA activity may contribute to the cellular response to stress.
Scott, Horowitz, James C A, Bardwell
openaire   +2 more sources

Long-Term Monitoring of Cardiac Involvement under Migalastat Treatment Using Magnetic Resonance Tomography in Fabry Disease

Life, 2023
Background: Fabry cardiomyopathy is characterized by left ventricular hypertrophy, myocardial fibrosis, arrhythmia, and premature death. Treatment with migalastat, an oral pharmacological chaperone, was associated with a stabilization of cardiac ...
Constantin Gatterer, Dietrich Beitzke, Senta Graf, Max Lenz, Gere Sunder-Plassmann, Christopher Mann, Markus Ponleitner, Robert Manka, Daniel Fritschi, Pierre-Alexandre Krayenbuehl, Philipp Kamm, Olivier Dormond, Frédéric Barbey, Pierre Monney, Albina Nowak   +14 more
doaj   +1 more source

The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex

mBio
To survive in harsh natural environments, translation and mRNA metabolism must be tightly and coordinately controlled, as saving biological costs increases fitness. However, the roles of protein chaperones in this control system are unclear.
Mitsuo Ogura, Yu Kanesaki, Hirofumi Yoshikawa, Koki Haga   +3 more
doaj   +1 more source