Results 11 to 20 of about 153,321 (216)

Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis

Frontiers in Oncology, 2022
Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is ...
Ting Wen, Qiao Yi Chen
doaj   +1 more source

Novel Chaperones RrGroEL and RrGroES for Activity and Stability Enhancement of Nitrilase in Escherichia coli and Rhodococcus ruber

Molecules, 2020
For large-scale bioproduction, thermal stability is a crucial property for most industrial enzymes. A new method to improve both the thermal stability and activity of enzymes is of great significance.
Chunmeng Xu, Lingjun Tang, Youxiang Liang, Song Jiao, Huimin Yu, Hui Luo   +5 more
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Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health

Frontiers in Cell and Developmental Biology, 2021
For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe, Brett Nixon, Heath Ecroyd, Heath Ecroyd, Jacinta H. Martin, David A. Skerrett-Byrne, Elizabeth G. Bromfield, Elizabeth G. Bromfield   +7 more
doaj   +1 more source

Calreticulin: Roles in Cell-Surface Protein Expression

Membranes, 2014
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane ...
Yue Jiang, Sandeepa Dey, Hiroaki Matsunami   +2 more
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HtrA chaperone activity contributes to host cell binding in Campylobacter jejuni

Gut Pathogens, 2011
Background Acute gastroenteritis caused by the food-borne pathogen Campylobacter jejuni is associated with attachment of bacteria to the intestinal epithelium and subsequent invasion of epithelial cells. In C.
Bæk Kristoffer T, Vegge Christina S, Brøndsted Lone   +2 more
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Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

eLife, 2019
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely ...
David F Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikasz-Nagy, Martí Aldea   +5 more
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Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cells

Frontiers in Pharmacology, 2023
Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype.
Naphannop Sereesongsaeng, James F. Burrows, Christopher J. Scott, Klaudia Brix, Roberta E. Burden   +4 more
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Similarities and Differences of Hsp70, hsc70, Grp78 and Mortalin as Cancer Biomarkers and Drug Targets

Cells, 2021
Background: Upregulation of Heath Shock Protein 70 (HSP70) chaperones supports cancer cell survival. Their high homology causes a challenge to differentiate them in experimental or prevention and treatment strategies.
Rajani Rai, Amy L. Kennedy, Zitha Redempta Isingizwe, Pouya Javadian, Doris Mangiaracina Benbrook   +4 more
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Long-Term Monitoring of Cardiac Involvement under Migalastat Treatment Using Magnetic Resonance Tomography in Fabry Disease

Life, 2023
Background: Fabry cardiomyopathy is characterized by left ventricular hypertrophy, myocardial fibrosis, arrhythmia, and premature death. Treatment with migalastat, an oral pharmacological chaperone, was associated with a stabilization of cardiac ...
Constantin Gatterer, Dietrich Beitzke, Senta Graf, Max Lenz, Gere Sunder-Plassmann, Christopher Mann, Markus Ponleitner, Robert Manka, Daniel Fritschi, Pierre-Alexandre Krayenbuehl, Philipp Kamm, Olivier Dormond, Frédéric Barbey, Pierre Monney, Albina Nowak   +14 more
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The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex

mBio
To survive in harsh natural environments, translation and mRNA metabolism must be tightly and coordinately controlled, as saving biological costs increases fitness. However, the roles of protein chaperones in this control system are unclear.
Mitsuo Ogura, Yu Kanesaki, Hirofumi Yoshikawa, Koki Haga   +3 more
doaj   +1 more source