A General Overview of Mesenchymal Stem Cell Therapies in Drug- and Chemical-Induced Liver Injury Models [PDF]
Gazi Medical JournalLiver injury is commonly seen in the population depending on the drug and chemical usage. Different groups of drugs and chemicals lead to different pathogeneses in the liver, such as necrosis, fibrosis, or inflammation.
Müşerref Şeyma Ceyhan +2 more
doaj +5 more sources
Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System [PDF]
Analytica, 2021 Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can
Antonio Marín-Romero +8 more
doaj +8 more sources
dialogi: Utilising NLP With Chemical and Disease Similarities to Drive the Identification of Drug-Induced Liver Injury Literature [PDF]
Frontiers in Genetics, 2022 Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M. Katritsis +7 more
semanticscholar +7 more sources
Supervised chemical graph mining improves drug-induced liver injury prediction [PDF]
iScience, 2022 Drug-induced liver injury (DILI) is the main cause of drug failure in clinical trials. The characterization of toxic compounds in terms of chemical structure is important because compounds can be metabolized to toxic substances in the liver. Traditional machine learning approaches have had limited success in predicting DILI, and emerging deep graph ...
Sangsoo Lim +5 more
semanticscholar +5 more sources
Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]
Biology Direct, 2021 Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether occurrence of DILI can be predicted using gene expression profile in cancer cell lines and ...
Wojciech Lesiński +3 more
semanticscholar +6 more sources
Prediction and mechanistic analysis of Drug-Induced Liver Injury (DILI) based on chemical structure [PDF]
Biology Direct, 2020 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Anika Liu +7 more
semanticscholar +9 more sources
Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure [PDF]
Biology Direct, 2021 Background Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are ...
Anika Liu +7 more
doaj +3 more sources
Development on Animal Models for Drug/Chemical Induced Liver Injury
Biomedical and Pharmacology Journal, 2023 In the human body, the largest gland is the liver and does a lot of essential work of the body. Liver damage is the cause of mortality and increasing day by day. Liver disease is caused by multiple factors, such as an autoimmune condition, toxic chemical exposure, viral infection, and dietary factors.
D. S. Bhatia +3 more
semanticscholar +3 more sources
Toxicology and Applied Pharmacology, 2022 Drug-induced liver injury (DILI) and cardiotoxicity (DICT) are major adverse effects triggered by many clinically important drugs. To provide an alternative to in vivo toxicity testing, the U.S. Tox21 consortium has screened a collection of ∼10K compounds, including drugs in clinical use, against >70 cell-based assays in a quantitative high-throughput ...
Lin Ye +10 more
semanticscholar +5 more sources
The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury [PDF]
Human & Experimental Toxicology, 2015 Idiosyncratic drug reactions can be extremely severe and are not accounted for by the regular pharmacology of a drug. Thus, the mechanism of idiosyncratic drug–induced liver injury (iDILI), a phenomenon that occurs with many drugs including β-lactams, anti-tuberculosis drugs and non-steroidal anti-inflammatories, has been difficult to determine and ...
Arun Tailor +3 more
semanticscholar +4 more sources