Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System [PDF]
Analytica, 2021 Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can
Antonio Marín-Romero +8 more
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Gazi Medical JournalLiver injury is commonly seen in the population depending on the drug and chemical usage. Different groups of drugs and chemicals lead to different pathogeneses in the liver, such as necrosis, fibrosis, or inflammation.
Müşerref Şeyma Ceyhan +2 more
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Editorial of Special Column on Drug- and Chemical-Induced Liver Injury
Acta Pharmaceutica Sinica B, 2021 James Luyendyk, Dafna Groeneveld
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Editor Profiles: Guest Editors of Special Column on Drug- and Chemical-Induced Liver Injury
Acta Pharmaceutica Sinica B, 2021 doaj +4 more sources
Treatment with gefitinib after erlotinib-induced liver injury: a case report [PDF]
Journal of Medical Case Reports, 2011 Introduction Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver
Nakatomi Katsumi +3 more
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Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure [PDF]
Biology Direct, 2021 Background Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are ...
Anika Liu +7 more
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Alpinetin pretreatment prevents lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by inhibiting ferroptosis via the Nrf2/SLC7A11/GPX4 pathway [PDF]
Scientific ReportsThis study aims to investigate whether alpinetin prevents lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute liver injury (ALI) in mice by inhibiting ferroptosis, and to explore the potential molecular mechanisms involved. Thirty-six male BALB/
Yujia Liu +4 more
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Advanced human liver models for the assessment of drug-induced liver injury [PDF]
Organoid, 2022 Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Seon Ju Mun +3 more
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Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice [PDF]
Acta Cirúrgica Brasileira, 2020 Purpose To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms. Methods Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups ...
Qian Wang, Yang Zhao, Bin Zang
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Gut Microbiota and Chemical-Induced Acute Liver Injury
Frontiers in Physiology, 2021 Background: Drug overdose or chemical exposures are the main causes of acute liver injury (ALI). Severe liver injury can develop into liver failure that is an important cause of liver-related mortality in intensive care units in most countries ...
Tao Chen, Tao Chen, Rui Li, Peng Chen
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