Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug‐induced liver injury [PDF]
Liver International, 2013 AbstractBackground & AimsSeveral pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug‐induced liver injury (DILI) development of the ABCB11 1331T>C polymorphism and the presence of specific chemical moieties, with known BSEP ...
Eugenia Ulzurrun +12 more
core +8 more sources
Supervised chemical graph mining improves drug-induced liver injury prediction [PDF]
iScience, 2022 Drug-induced liver injury (DILI) is the main cause of drug failure in clinical trials. The characterization of toxic compounds in terms of chemical structure is important because compounds can be metabolized to toxic substances in the liver. Traditional machine learning approaches have had limited success in predicting DILI, and emerging deep graph ...
Sangsoo Lim +5 more
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dialogi: Utilising NLP with chemical and disease similarities to drive the identification of Drug-Induced Liver Injury literature [PDF]
Frontiers in Genetics, 2022 Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M. Katritsis +7 more
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Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]
Biology Direct, 2021 Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether occurrence of DILI can be predicted using gene expression profile in cancer cell lines and ...
Wojciech Lesiński +3 more
openalex +5 more sources
MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury [PDF]
Journal of Clinical Medicine, 2015 Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries, while the latter is the most common reason for post-marketing drug withdrawal and a major reason for ...
Mitchell R. McGill, Hartmut Jaeschke
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Prediction and mechanistic analysis of Drug-Induced Liver Injury (DILI) based on chemical structure [PDF]
Biology Direct, 2020 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Anika Liu +7 more
openalex +8 more sources
The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury [PDF]
Human & Experimental Toxicology, 2015 Idiosyncratic drug reactions can be extremely severe and are not accounted for by the regular pharmacology of a drug. Thus, the mechanism of idiosyncratic drug–induced liver injury (iDILI), a phenomenon that occurs with many drugs including β-lactams, anti-tuberculosis drugs and non-steroidal anti-inflammatories, has been difficult to determine and ...
Arun Tailor +3 more
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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury [PDF]
Toxicological Sciences, 2020 Abstract Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabolites (CRMs) contribute to liver-associated adverse drug reactions in humans that
James J Monroe +17 more
openalex +4 more sources
Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System [PDF]
Analytica, 2021 Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can detect early liver injury and inform about mechanistic basis.
Antonio Marín-Romero +8 more
openalex +7 more sources
Toxicology and Applied Pharmacology, 2022 Drug-induced liver injury (DILI) and cardiotoxicity (DICT) are major adverse effects triggered by many clinically important drugs. To provide an alternative to in vivo toxicity testing, the U.S. Tox21 consortium has screened a collection of ∼10K compounds, including drugs in clinical use, against70 cell-based assays in a quantitative high-throughput ...
Lin Ye +10 more
openalex +4 more sources