Gazi Medical JournalLiver injury is commonly seen in the population depending on the drug and chemical usage. Different groups of drugs and chemicals lead to different pathogeneses in the liver, such as necrosis, fibrosis, or inflammation.
Müşerref Şeyma Ceyhan +2 more
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Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System [PDF]
Analytica, 2021 Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can
Antonio Marín-Romero +8 more
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Editorial of Special Column on Drug- and Chemical-Induced Liver Injury
Acta Pharmaceutica Sinica B, 2021 James Luyendyk, Dafna Groeneveld
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Supervised chemical graph mining improves drug-induced liver injury prediction [PDF]
iScience, 2022 Drug-induced liver injury (DILI) is the main cause of drug failure in clinical trials. The characterization of toxic compounds in terms of chemical structure is important because compounds can be metabolized to toxic substances in the liver. Traditional machine learning approaches have had limited success in predicting DILI, and emerging deep graph ...
Sangsoo Lim +5 more
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dialogi: Utilising NLP With Chemical and Disease Similarities to Drive the Identification of Drug-Induced Liver Injury Literature [PDF]
Frontiers in Genetics, 2022 Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M Katritsis +7 more
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Editor Profiles: Guest Editors of Special Column on Drug- and Chemical-Induced Liver Injury
Acta Pharmaceutica Sinica B, 2021 doaj +4 more sources
MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury [PDF]
Journal of Clinical Medicine, 2015 Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries, while the latter is the most common reason for post-marketing drug withdrawal and a major reason for ...
Mitchell R. McGill, Hartmut Jaeschke
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Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]
Biology Direct, 2021 Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether occurrence of DILI can be predicted using gene expression profile in cancer cell lines and ...
Wojciech Lesiński +3 more
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Prediction and mechanistic analysis of Drug-Induced Liver Injury (DILI) based on chemical structure [PDF]
Biology Direct, 2020 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Anika Liu +7 more
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The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury [PDF]
Human & Experimental Toxicology, 2015 Idiosyncratic drug reactions can be extremely severe and are not accounted for by the regular pharmacology of a drug. Thus, the mechanism of idiosyncratic drug–induced liver injury (iDILI), a phenomenon that occurs with many drugs including β-lactams, anti-tuberculosis drugs and non-steroidal anti-inflammatories, has been difficult to determine and ...
Arun Tailor +3 more
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