Results 11 to 20 of about 92,867 (160)

Chemical and biochemical aspects of drug-induced liver injury [PDF]

, 2011
Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing stage, and is a key cause of drug attrition.
Rachel J. Walsh
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Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury [PDF]

Archives of Toxicology, 2018
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI). However, very little is known about the makeup of the NRF2 transcriptional network and its response to ...
Copple, I.M., Hollander, W. den, Callegaro, G., Mutter, F.E., Maggs, J.L., Schofield, A.L., Rainbow, L., Fang, Y., Sutherland, J.J., Ellis, E.C., Ingelman-Sundberg, M., Fenwick, S.W., Goldring, C.E., Water, B. van de, Stevens, J.L., Park, B.K.   +15 more
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Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug‐induced liver injury

Liver International, 2013
AbstractBackground & AimsSeveral pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug‐induced liver injury (DILI) development of the ABCB11 1331T>C polymorphism and the presence of specific chemical moieties, with known BSEP ...
Ulzurrun, Eugenia, Stephens, Camilla, Crespo, Esperanza, Ruiz-Cabello, Francisco, Ruiz-Nuñez, Julia, Saenz-López, Pablo, Moreno-Herrera, Inmaculada, Robles-Díaz, María Mercedes, Hallal, Hacibe, Moreno-Planas, José María, Cabello-Porras, María Rosario, Lucena-González, María Isabel, Andrade-Bellido, Raúl Jesús   +12 more
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The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury [PDF]

Human & Experimental Toxicology, 2015
Idiosyncratic drug reactions can be extremely severe and are not accounted for by the regular pharmacology of a drug. Thus, the mechanism of idiosyncratic drug–induced liver injury (iDILI), a phenomenon that occurs with many drugs including β-lactams, anti-tuberculosis drugs and non-steroidal anti-inflammatories, has been difficult to determine and ...
A, Tailor, L, Faulkner, D J, Naisbitt, B K, Park   +3 more
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Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury

Chemical Research in Toxicology, 2019
Idiosyncratic drug-induced liver injury (iDILI), which is rare and often recognized only late in drug development, poses a major public health concern and impediment to drug development due to its high rate of morbidity and mortality. The mechanisms of DILI are not completely understood; both non-immune- and immune-mediated mechanisms have been ...
Serat-E Ali, James C. Waddington, B. Kevin Park, Xiaoli Meng   +3 more
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pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints [PDF]

ACS Omega
Drug-induced liver injury (DILI) represents a critical safety concern for drug development, regulatory oversight, and clinical practice, with substantial economic and public health implications. While predicting DILI risk in humans has garnered significant attention, the associated chemical space has remained insufficiently explored.
Sk Abdul Amin, Supratik Kar, Stefano Piotto   +2 more
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Chemical modification and signalling of redox-sensitive transcription factors in the adaptive response to drug-induced liver injury [PDF]

, 2019
Alvin J. L. Chia
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LincRNA-p21: A Double-Edged Sword in Ethanol-Induced Liver Damage and Its Nanoparticle Solution [PDF]

International Journal of Nanomedicine
Shun Wang,1 Zhao-Chao Nie,1 Yang Liu,2 Zhi-Yue Zhang,2 Yi-Min Feng,1 Chengwei Wang,3 Jun Jiang3 1Department of Clinical Laboratory, The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 2NMPA Key Laboratory
Wang S, Nie ZC, Liu Y, Zhang ZY, Feng YM, Wang C, Jiang J   +6 more
doaj   +2 more sources

Advanced human liver models for the assessment of drug-induced liver injury [PDF]

Organoid, 2022
Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Seon Ju Mun, Jaeseo Lee, Yongbo Shin, Myung Jin Son   +3 more
doaj   +1 more source

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms. Methods Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups ...
Qian Wang, Yang Zhao, Bin Zang
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