Results 11 to 20 of about 194,011 (303)
dialogi: Utilising NLP With Chemical and Disease Similarities to Drive the Identification of Drug-Induced Liver Injury Literature [PDF]
Frontiers in Genetics, 2022 Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M. Katritsis +7 more
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MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury [PDF]
Journal of Clinical Medicine, 2015 Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries, while the latter is the most common reason for post-marketing drug withdrawal and a major reason for ...
Mitchell R. McGill, Hartmut Jaeschke
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Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]
Biology Direct, 2021 Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether occurrence of DILI can be predicted using gene expression profile in cancer cell lines and ...
Wojciech Lesiński +3 more
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Prediction and mechanistic analysis of Drug-Induced Liver Injury (DILI) based on chemical structure [PDF]
Biology Direct, 2020 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Anika Liu +7 more
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Development on Animal Models for Drug/Chemical Induced Liver Injury
Biomedical and Pharmacology Journal, 2023 In the human body, the largest gland is the liver and does a lot of essential work of the body. Liver damage is the cause of mortality and increasing day by day. Liver disease is caused by multiple factors, such as an autoimmune condition, toxic chemical exposure, viral infection, and dietary factors.
D. S. Bhatia +3 more
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PLOS ONE, 2021 Drug-induced liver injury (DILI) is one of major causes of discontinuing drug development and withdrawing drugs from the market. In this study, we investigated chemical properties associated with DILI using in silico methods, to identify a physicochemical property useful for DILI screening at the early stages of drug development.
Yuki Shimizu +6 more
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Supervised chemical graph mining improves drug-induced liver injury prediction
iScience, 2022 Drug-induced liver injury (DILI) is the main cause of drug failure in clinical trials. The characterization of toxic compounds in terms of chemical structure is important because compounds can be metabolized to toxic substances in the liver. Traditional machine learning approaches have had limited success in predicting DILI, and emerging deep graph ...
Sangsoo Lim +5 more
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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury [PDF]
Toxicological Sciences, 2020 Abstract Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabolites (CRMs) contribute to liver-associated adverse drug reactions in humans that
James J Monroe +17 more
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Chemical and biochemical aspects of drug-induced liver injury [PDF]
, 2011 Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing stage, and is a key cause of drug attrition.
Rachel J. Walsh
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Liver International, 2013 AbstractBackground & AimsSeveral pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug‐induced liver injury (DILI) development of the ABCB11 1331T>C polymorphism and the presence of specific chemical moieties, with known BSEP ...
Eugenia Ulzurrun +12 more
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