Results 11 to 20 of about 219,574 (288)

dialogi: Utilising NLP With Chemical and Disease Similarities to Drive the Identification of Drug-Induced Liver Injury Literature

Frontiers in Genetics, 2022
Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs ...
Nicholas M Katritsis, Anika Liu, G. Youssef, Sanjay Rathee, Méabh MacMahon, Woochang Hwang, Lilly Wollman, N. Han   +7 more
semanticscholar   +4 more sources

Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure [PDF]

Biology Direct, 2020
Background Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are ...
Anika Liu, Moritz Walter, P. Wright, A. Bartosik, Daniela Dolciami, Abdurrahman Elbasir, Hongbin Yang, A. Bender   +7 more
semanticscholar   +7 more sources

Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]

Biology Direct, 2020
Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials.
W. Lesiński, Krzysztof Mnich, A. Golinska, W. Rudnicki   +3 more
semanticscholar   +4 more sources

Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System [PDF]

Analytica, 2021
Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can
Antonio Marín-Romero, Mavys Tabraue-Chávez, Bárbara López-Longarela, M. A. Fara, R. Sánchez-Martín, J. Dear, Hugh Ilyine, J. Díaz-Mochón, Salvatore Pernagallo   +8 more
semanticscholar   +5 more sources

Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data.

Toxicology and Applied Pharmacology, 2022
Drug-induced liver injury (DILI) and cardiotoxicity (DICT) are major adverse effects triggered by many clinically important drugs. To provide an alternative to in vivo toxicity testing, the U.S. Tox21 consortium has screened a collection of ∼10K compounds, including drugs in clinical use, against >70 cell-based assays in a quantitative high-throughput ...
Lin Ye, Deborah K. Ngan, Tuan Xu, Zhichao Liu, Jinghua Zhao, S. Sakamuru, Li Zhang, Tongan Zhao, M. Xia, A. Simeonov, Ruili Huang   +10 more
semanticscholar   +3 more sources

Definition of the Chemical and Immunological Signals Involved in Drug-induced Liver Injury.

Chemical Research in Toxicology, 2020
Idiosyncratic drug-induced liver injury (iDILI), which is rare and often recognized only late in drug development, poses a major public health concern and impediment to drug development due to its high rate of morbidity and mortality.
S. Ali, J. Waddington, Kevin B. Park, Xiaoli Meng   +3 more
semanticscholar   +3 more sources

pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints

ACS Omega
Drug-induced liver injury (DILI) represents a critical safety concern for drug development, regulatory oversight, and clinical practice, with substantial economic and public health implications.
S. Amin, Supratik Kar, Stefano Piotto
semanticscholar   +4 more sources

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury [PDF]

Archives of Toxicology, 2018
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI).
I. Copple, I. Copple, W. D. Hollander, G. Callegaro, F. Mutter, J. Maggs, Amy L. Schofield, L. Rainbow, Yongxiang Fang, J. Sutherland, Ewa C. S. Ellis, M. Ingelman-Sundberg, S. Fenwick, C. Goldring, B. Water, J. Stevens, B. Park   +16 more
semanticscholar   +5 more sources

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury [PDF]

Journal of Clinical Medicine, 2015
Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries, while the latter is the most common reason for post-marketing drug withdrawal and a major reason for ...
Mitchell McGill, Hartmut Jaeschke
openaire   +2 more sources

Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

Biology Direct, 2021
Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently ...
Anika Liu, Moritz Walter, P. Wright, A. Bartosik, Daniela Dolciami, Abdurrahman Elbasir, Hongbin Yang, A. Bender   +7 more
semanticscholar   +1 more source