Development on Animal Models for Drug/Chemical Induced Liver Injury
Biomedical and Pharmacology Journal, 2023 In the human body, the largest gland is the liver and does a lot of essential work of the body. Liver damage is the cause of mortality and increasing day by day. Liver disease is caused by multiple factors, such as an autoimmune condition, toxic chemical exposure, viral infection, and dietary factors.
D. S. Bhatia +3 more
openalex +2 more sources
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury [PDF]
Archives of Toxicology, 2018 The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI). However, very little is known about the makeup of the NRF2 transcriptional network and its response to ...
Ian M. Copple +15 more
openalex +5 more sources
Frontiers in Pharmacology, 2022 Excessive stimulation of hepatotoxins and drugs often lead to acute liver injury, while treatment strategies for acute liver injury have been limited. Methyl 6-O-cinnamoyl-α-d-glucopyranoside (MCGP) is a structure modified compound from cinnamic acid, a ...
Qianqian Xu +13 more
doaj +1 more source
LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS
Arquivos de Gastroenterologia, 2022 Background: The intake of dietary supplements and medicinal plants is very popular worldwide. However, these products are not innocuous, and their intake can cause severe damage to health, especially liver injury. Objective: This study aims to describe
Michelle Hoff de ASSIS +3 more
doaj +1 more source
INFLUENCE OF HIGH-DOSE ATORVASTATIN ON BILE ACID METABOLISM IN MICE WITH LIVER INJURY AND RELATED MECHANISM [PDF]
精准医学杂志, 2023 Objective To investigate the influence of high-dose atorvastatin on bile acid metabolism in mice with liver injury and its mechanism. Methods A total of 40 specific pathogen-free male C57BL/6 mice were randomly divided into normal saline group (group A ...
XIA Feifei, SONG Bingxue, SONG Yuqing, TIAN Jiawei, YAN Hui, HUANG Yuxiao, XIN Hui, LIANG Hui
doaj +1 more source
Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]
Clinical and Molecular Hepatology, 2020 Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low +3 more
doaj +1 more source
Drug-induced liver injury due to tofacitinib: a case report
Journal of Medical Case Reports, 2023 Background Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Case presentation In the present work, liver failure following the use of tofacitinib was reported.
Masoud Mardani +3 more
doaj +1 more source
Hyperin protects against cisplatin-induced liver injury in mice [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was ...
Chengwei Niu +4 more
doaj +1 more source
HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE [PDF]
Arquivos de Gastroenterologia, 2019 BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes.
Izabela Rangel LIMA +5 more
doaj +1 more source