Results 21 to 30 of about 2,835,752 (355)

Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats [PDF]

Majalah Kedokteran Bandung
The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active ...
Agni Febrina Pargaputri, Endah Wahjuningsih, Dwi Andriani   +2 more
doaj   +3 more sources

Investigation of the Role of Chemical Analysis in Causality Assessment of Herbal and Dietary Supplement-Induced Liver Injury. [PDF]

Drug Saf
Background The attribution of drug-induced liver injury (DILI) to specific herbal and dietary supplements (HDS) is confounded by inaccurate labels and undisclosed ingredients. The US Drug-Induced Liver Injury Network (DILIN) determines the attribution of
Halegoua-DeMarzio D, Navarro VJ, Davis A, Ahmad J, Avula B, Barnhart H, Barritt AS, Bonkovsky HL, Chen VL, Choi G, Fontana RJ, Ghabril MS, Khan I, Koh C, Odin J, Rockey DC, Rostami H, Serrano J, Sherker AH, Stolz A, Tillmann HL, Vuppalanchi R, Drug-Induced Liver Injury Network.   +22 more
europepmc   +2 more sources

pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints [PDF]

ACS Omega
Amin S, Kar S, Piotto S.
europepmc   +3 more sources

Advanced human liver models for the assessment of drug-induced liver injury [PDF]

Organoid, 2022
Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Seon Ju Mun, Jaeseo Lee, Yongbo Shin, Myung Jin Son   +3 more
doaj   +1 more source

Chemical modification and signalling of redox-sensitive transcription factors in the adaptive response to drug-induced liver injury [PDF]

, 2011
Alvin J. L. Chia
openalex   +3 more sources

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms. Methods Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups ...
Qian Wang, Yang Zhao, Bin Zang
doaj   +1 more source

Gut Microbiota and Chemical-Induced Acute Liver Injury

Frontiers in Physiology, 2021
Background: Drug overdose or chemical exposures are the main causes of acute liver injury (ALI). Severe liver injury can develop into liver failure that is an important cause of liver-related mortality in intensive care units in most countries ...
Tao Chen, Tao Chen, Rui Li, Peng Chen
doaj   +1 more source

684 EFFECTS OF CHEMICAL MOIETIES AND POLYMORPHISMS IN THE HUMAN ABC TRANSPORTER ABCB1 (P-GLYCOPROTEIN/MDR1) IN DRUG-INDUCED LIVER INJURY

Journal of Hepatology, 2011
Eugenia Ulzurrun, Esperanza Crespo, Francisco Ruiz‐Cabello, Camilla Stephens, Y. Borraz, Mercedes Robles‐Díaz, M.R. Cabello, M. Carmen Fernández, Gloria Isabel Carvajal Peláez, Manuel Romero‐Gómez, J.M. Navarro, Ramón Planas, J. Salmerón, Carlos Guarner, Agustín Castiella, M. Isabel Lucena, Raúl J. Andrade   +16 more
openalex   +3 more sources

The Effectiveness of Silymarin in the Prevention of Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Randomized Controlled Clinical Trial

International Journal of Preventive Medicine, 2023
Background: Several animal studies have shown the protective effect of silymarin (the extract of Silybum marianum seeds) against anti-tuberculosis drug-induced hepatotoxicity (ATDH). However, the knowledge of ATDH of silymarin in humans is scarce.
Ali Talebi, Rasool Soltani, Farzin Khorvash, Soroush Mohammadi Jouabadi   +3 more
doaj   +1 more source

Machine Learning-Based Approach for Predicting Drug-Induced Liver Injury of Chemical Compounds

Journal of KIISE, 2023
Soyeon Lee, Sunyong Yoo
openalex   +2 more sources