Results 21 to 30 of about 194,011 (303)

Chemical modification and signalling of redox-sensitive transcription factors in the adaptive response to drug-induced liver injury [PDF]

, 2019
Alvin J. L. Chia
openalex   +2 more sources

Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data

Toxicology and Applied Pharmacology, 2022
Drug-induced liver injury (DILI) and cardiotoxicity (DICT) are major adverse effects triggered by many clinically important drugs. To provide an alternative to in vivo toxicity testing, the U.S. Tox21 consortium has screened a collection of ∼10K compounds, including drugs in clinical use, against >70 cell-based assays in a quantitative high-throughput ...
Lin Ye, Deborah K. Ngan, Tuan Xu, Zhichao Liu, Jinghua Zhao, Srilatha Sakamuru, Li Zhang, Tongan Zhao, Menghang Xia, Anton Simeonov, Ruili Huang   +10 more
openalex   +4 more sources

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury [PDF]

Archives of Toxicology, 2018
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI). However, very little is known about the makeup of the NRF2 transcriptional network and its response to ...
Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona Mutter, James L. Maggs, Amy Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa Ellis, Magnus Ingelman‐Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James Stevens, B. Kevin Park   +15 more
openalex   +5 more sources

The Effectiveness of Silymarin in the Prevention of Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Randomized Controlled Clinical Trial

International Journal of Preventive Medicine, 2023
Background: Several animal studies have shown the protective effect of silymarin (the extract of Silybum marianum seeds) against anti-tuberculosis drug-induced hepatotoxicity (ATDH). However, the knowledge of ATDH of silymarin in humans is scarce.
Ali Talebi, Rasool Soltani, Farzin Khorvash, Soroush Mohammadi Jouabadi   +3 more
doaj   +1 more source

pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints [PDF]

ACS Omega
Drug-induced liver injury (DILI) represents a critical safety concern for drug development, regulatory oversight, and clinical practice, with substantial economic and public health implications. While predicting DILI risk in humans has garnered significant attention, the associated chemical space has remained insufficiently explored.
Sk. Abdul Amin, Supratik Kar, Stefano Piotto   +2 more
openalex   +4 more sources

Methyl 6-O-cinnamoyl-α-d-glucopyranoside Ameliorates Acute Liver Injury by Inhibiting Oxidative Stress Through the Activation of Nrf2 Signaling Pathway

Frontiers in Pharmacology, 2022
Excessive stimulation of hepatotoxins and drugs often lead to acute liver injury, while treatment strategies for acute liver injury have been limited. Methyl 6-O-cinnamoyl-α-d-glucopyranoside (MCGP) is a structure modified compound from cinnamic acid, a ...
Qianqian Xu, Yanfang Deng, Jiaxiong Ming, Zengwei Luo, Xia Chen, Tianqi Chen, Yafen Wang, Shan Yan, Jiajun Zhou, Lina Mao, Weiguang Sun, Qun Zhou, Hong Ren, Yonghui Zhang   +13 more
doaj   +1 more source

LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS

Arquivos de Gastroenterologia, 2022
Background: The intake of dietary supplements and medicinal plants is very popular worldwide. However, these products are not innocuous, and their intake can cause severe damage to health, especially liver injury. Objective: This study aims to describe
Michelle Hoff de ASSIS, Bruna Cherubini ALVES, Vivian Cristine LUFT, Valesca DALL’ALBA   +3 more
doaj   +1 more source

Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]

, 2015
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia, Badiani, Aldo, Grassi, Maria Caterina, Graziani, Manuela, Saso, Luciano, Togna, Anna Rita   +5 more
core   +12 more sources

The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics

Food Science and Human Wellness, 2021
Trametes lactinea mycelia polysaccharides (TLMPS) have a wide range of bioactivities. The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of ...
Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu   +5 more
doaj   +1 more source

Drug-induced liver injury due to tofacitinib: a case report

Journal of Medical Case Reports, 2023
Background Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Case presentation In the present work, liver failure following the use of tofacitinib was reported.
Masoud Mardani, Jafar Mohammadshahi, Sara abolghasemi, Roghayeh Teimourpour   +3 more
doaj   +1 more source