Results 31 to 40 of about 76,307 (263)
Critical Care, 2022 Background A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine. Simultaneously, an increased
Pedro David Wendel-Garcia +10 more
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Archives of Academic Emergency Medicine, 2023 Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice ...
Akram Jamshidzadeh +4 more
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Relevance of Pharmacogenomics to the Safe Use of Antimicrobials
Antibiotics, 2023 There has been widespread implementation of pharmacogenomic testing to inform drug prescribing in medical specialties such as oncology and cardiology. Progress in using pharmacogenomic tests when prescribing antimicrobials has been more limited, though a
Ann K. Daly
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Pharmacological correction of hepatotoxicity induced by anti-tuberculosis drugs
Лечащий Врач, 2023 Drug-induced liver injury are one of the most frequent undesirable effects of drug therapy in tuberculosis patients. Hepatoprotective drugs of various origin and chemical composition are used for the correction and prevention of drug-induced liver injury.
D. S. Sukhanov +3 more
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Acute Hepatitis Associated with Intake of Pistacia Vera L. Bud Tea; a Case Report
Archives of Academic Emergency Medicine, 2023 In this study, a patient who developed acute hepatitis due to drinking Pistacia vera L. bud tea is presented. A twenty-eight-year-old woman who had just come out of the postpartum period applied to our clinic with complaints of nausea, vomiting, loss of
Kazım Ersin Altınsoy +1 more
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PROSPECTIVE MONITORING OF DRUG USE: DRUG-INDUCED LIVER INJURY IN A PRIMARY HEALTHCARE CENTER [PDF]
Arquivos de Gastroenterologia, 2019 BACKGROUND: Drug-induced liver injury is still misunderstood in Brazil due to diagnostic difficulties or lack of reporting incidents. OBJECTIVE: To assess the frequency of adverse events related to the use of medicines in a primary healthcare unit, in
Nília Maria de Brito Lima PRADO +5 more
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Treatment with gefitinib after erlotinib-induced liver injury: a case report
Journal of Medical Case Reports, 2011 Introduction Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver
Nakatomi Katsumi +3 more
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Chemical and biochemical aspects of drug-induced liver injury [PDF]
, 2011 Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing stage, and is a key cause of drug attrition.
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, 2021 Additional file 8: TableS3. Pathways with high feature importance in RF and SVM, and links to DILI. The overrepresented gene sets for 19 proteins with the highest feature importance in RF or SVM models are shown. Many pathways identified possess known functions in liver drug metabolism and cell stress.
Liu, Anika +7 more
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, 2021 Additional file 4: Figure S3. Enriched pathways across different feature importance cutoffs for RF using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika +7 more
openaire +2 more sources