Results 81 to 90 of about 596,259 (322)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Modelling the chemical evolution

, 2010
Advanced observational facilities allow to trace back the chemical evolution of the Universe, on the one hand, from local objects of different ages and, secondly, by direct observations of redshifted objects.
Argast, Cescutti, Chiappini, Colavitti, Gerhard Hensler, Harfst, Hensler, Hensler, Hensler, Hensler, Hirschi, Ikuta, Koch, Koeppen, Koeppen, Kroeger, Maciel, Maeder, Matteucci, Meynet, Meynet, Meynet, Momany, Nordstroem, Pagel, Pagel, Portinari, Portinari, Prantzos, Prantzos, Recchi, Recchi, Recchi, Recchi, Revaz, Samland, Schaller, Simone Recchi, Spitoni, Theis, Tinsley   +40 more
core   +1 more source

Chemical enrichment of isolated relic galaxy Mrk1216

Publications of the Astronomical Society of Australia
Abstract In this study, we investigate the chemical enrichment and structural evolution of the isolated elliptical relic galaxy Mrk1216 through X-ray observations. As a red-nugget relic, Mrk1216 provides a rare window into the early Universe, owing to its minimal interaction with the surrounding environment. Using data from the XMM-Newton telescope,
M. Kıyami Erdim, Emine Gülmez, Murat Hüdaverdi   +2 more
openaire   +2 more sources

Chemical Enrichment of the First Binaries [PDF]

Proceedings of the International Astronomical Union, 2015
AbstractRecent studies of Population III (Pop III) star formation suggest that the primordial star-forming clouds can fragment to form binary or multiple stellar systems inside dark matter minihalos. Here, we briefly present the chemical enrichment of the Pop III binary scenarios.
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

AEOS: Star-by-star Cosmological Simulations of Early Chemical Enrichment and Galaxy Formation

The Astrophysical Journal
The A eos project introduces a series of high-resolution cosmological simulations that model star-by-star chemical enrichment and galaxy formation in the early Universe, achieving 1 pc resolution.
Kaley Brauer, Andrew Emerick, Jennifer Mead, Alexander P. Ji, John H. Wise, Greg L. Bryan, Mordecai-Mark Mac Low, Benoit Côté, Eric P. Andersson, Anna Frebel   +9 more
doaj   +1 more source

Comparative study on pore-connectivity and wettability characteristics of the fresh-water and saline lacustrine tuffaceous shales: triggering mechanisms and multi-scale models for differential reservoir-forming patterns

Frontiers in Earth Science
Although particular attention has been paid to responses of hydrocarbon storage and percolation capacity to the devitrification concerning lacustrine tuffaceous shale reservoirs in recent years, there is still a lack of systematical and comparative ...
Wei Yang, Wei Yang, Baojian Shen, Baojian Shen, Zilong Zhang, Rui Zhao, Rui Zhao, Haodong Hou, Zhiming Li, Zhiming Li, Mou Ding, Hanwen Hu, Fan Feng, Ming Xie   +13 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source