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International Journal of Cancer, 2004 AbstractThe chemokines and their receptors are a superfamily of small secreted molecules that control the migration of many cell types in the body. Several years ago it became clear that some chemokines and receptors regulate the migration of certain cells in the lymphoid system, and this raised the possibility that chemokines could also control the ...
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Chemokines, chemokine receptors and hematopoiesis
Immunological Reviews, 2000Hematopoiesis during steady state conditions is regulated and finely tuned by a network of cytokines and their effects on hematopoietic stem and progenitor cells and on accessory cells that influence the stem and progenitor cells. Amongst the numerous cytokines implicated in this regulation are members of the CC, CXC and C family of chemokines.
Hal E. Broxmeyer +2 more
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Cytokine & Growth Factor Reviews, 2001
Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Chemokines and Chemokine Receptors
2001The recruitment of cells to sites of inflammation is an essential component of the host inflammatory response. Cell recruitment relies on the coordinated action of cell activation, cell adhesion, chemoattraction, and transmigration across the endothelial barrier.
James A. MacLean, Andrew D. Luster
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Developmental & Comparative Immunology, 2004
Chemokines are small proteins that control cellular migration. An extensive family of these molecules has been described in mammals containing nearly 50 members. Within this family are four groups, each defined by the different spacing of two N-terminal cysteines, which form disulphide bonds with two other cysteine residues to create the tertiary ...
Kerry J, Laing, Christopher J, Secombes
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Chemokines are small proteins that control cellular migration. An extensive family of these molecules has been described in mammals containing nearly 50 members. Within this family are four groups, each defined by the different spacing of two N-terminal cysteines, which form disulphide bonds with two other cysteine residues to create the tertiary ...
Kerry J, Laing, Christopher J, Secombes
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Chemokines and Chemokine Receptors
1999Classic chemoattractants include complement components, formyl peptides and leukotriene B4. In addition, various cytokines are able to elicit directional migration of leukocytes. While molecules such as monocyte-colony stimulating factor or tumor necrosis factor also exert chemotactic activity, the main chemotactic cytokines are a superfamily of ...
Annunciata Vecchi +6 more
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Chemokine Receptors and Chemokines in HIV Infection
Journal of Clinical Immunology, 1998Suppression of HIV by chemokines represents a special case in virology and immunology where soluble molecules other than antibodies inhibit infection by a specific virus. The basis for this inhibition is that HIV has evolved to use certain chemokine receptors as "coreceptors" for entry into host cells.
GARZINO DEMO, ALFREDO +2 more
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2009
Tumor growth is restricted to approximately 2 microm diameters by simple dissociation of nutrients and oxygen. Hence, tumors require the formation of new blood vessels for further growth progression. This process is referred to as tumor neo-angiogenesis. The process of tumor neo-angiogenesis is directed by complex bidirectional interactions between the
Andreas, Hippe +2 more
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Tumor growth is restricted to approximately 2 microm diameters by simple dissociation of nutrients and oxygen. Hence, tumors require the formation of new blood vessels for further growth progression. This process is referred to as tumor neo-angiogenesis. The process of tumor neo-angiogenesis is directed by complex bidirectional interactions between the
Andreas, Hippe +2 more
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Chemokine–Chemokine Receptors in Cancer Immunotherapy
Immunotherapy, 2008A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit
J. Stewart, Trina, J. Smyth, Mark
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Introduction to Chemokines and Chemokine Antagonists
2004Chemokines are small, soluble proteins with four conserved cysteines (Baggiolini et al. 1994, 1997). They consist of about 70–130 amino acids yielding molecular weights in the range of 7–15 kDa, and are synthesized with a leader sequence of 20–25 amino acids, which is cleaved off before release.
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